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One or more keywords matched the following properties of Tissenbaum, Heidi

Academic Background

Heidi Tissenbaum received her B.S. in Biology from Concordia University in Montreal, Quebec, Canada and an M.S. degree in Physiology from the University of Ottawa, in Ontario, Canada. In 1997, she graduated with a Ph.D. in Genetics from Harvard Medical School. From 1997 to 2001, she was a post-doc at MIT where she was supported by the Helen Hay Whitney Foundation. In 2001, Dr. Tissenbaum joined the Program in Gene Function and Expression at the University of Massachusetts Medical School, and also received a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund. Dr. Tissenbaum has received funding from the American Federation of Aging Research, the Worcester Foundation for Biomedical Research, the Concern Foundation, and the National Institute of Aging. Dr. Tissenbaum is also a William Randolph Hearst Young Investigator.


Defining healthy aging

Photo: Heidi 

We age. Some of us age better than others. Some of us show prolonged health. Our research focuses on understanding the fundamental processes that define how we age. We use a combination of molecular biology, genetics, biochemistry, and genomics to define: what contributes to lifespan? What defines healthy aging (healthspan)? What dictates metabolic health? How does the environment contribute? What about nutrition/diet? Overall, we want to determine the critical pathways/genes that define health. 

Specific Interests

  1. In C. elegans, the insulin/IGF-1 signaling pathway plays a central role in regulating lifespan, fat storage, stress and development. What are all the genes involved? How is each specific phenotype modulated? Are they modulated together?
  2. How do multiple conserved signaling pathways couple to the insulin/IGF-1 pathway to regulate lifespan? Fat storage? Stress? Development?
  3. How does the forkhead transcription factor DAF-16 function as a central mediator in C. elegans?


Photo: Heidi 

One or more keywords matched the following items that are connected to Tissenbaum, Heidi
Item TypeName
Academic Article An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
Academic Article Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
Academic Article The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Academic Article JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Academic Article C. elegans tubby regulates life span and fat storage by two independent mechanisms.
Academic Article InAKTivation of insulin/IGF-1 signaling by dephosphorylation.
Academic Article Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
Academic Article Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
Academic Article A gene-centered C. elegans protein-DNA interaction network.
Academic Article Worming pathways to and from DAF-16/FOXO.
Academic Article C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
Academic Article Serotonin's SOS signal.
Academic Article Reproduction and longevity: secrets revealed by C. elegans.
Academic Article Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans.
Academic Article A new DAF-16 isoform regulates longevity.
Academic Article DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road.
Academic Article PDP-1 links the TGF-? and IIS pathways to regulate longevity, development, and metabolism.
Academic Article Integration of ?-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.
Concept Forkhead Transcription Factors
Concept Transcription Factors
Academic Article DAF-16: FOXO in the Context of C. elegans.
Academic Article Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans.
Search Criteria
  • Transcription Factors