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One or more keywords matched the following properties of Martin, Gilles
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EDUCATION

1988 Université Pierre et Marie Curie (Paris, France) B.A., Neurophysiology
1989 Université Pierre et Marie Curie (Paris, France) M.A., Neurobiology
1993 Université Pierre et Marie Curie (Paris, France) Ph.D., Neurobiology

PROFESSIONAL APPOINTMENTS

1993 – 1995Postdoctoral Research Associate
The Max-Planck Institute, Munich, Germany

1995 – 2001Postdoctoral Research Associate
Department of Neuropharmacology
The Scripps Research Institute, San Diego, CA

2001-2012 Research Assistant Professor
Department of Psychiatry
The Brudnick Neuropsychiatric Research Institute
University of Massachusetts Medical School, Worcester, MA

2012-present Assistant Professor
Department of Neurobiology
The Brudnick Neuropsychiatric Research Institute
University of Massachusetts Medical School, Worcester, MA

RESEARCH

The hallmark of all drugs of abuse, including alcohol, is their powerful addictive properties that linger for years after the last drug intake. It has been proposed that addiction and relapse may both result from altered mnemonic processes caused by changes in the strength of synaptic communication between nerve cells, the main objective of my research.

Drugs of abuse and synaptic plasticity

Our main focus is to understand how early alcohol exposure (i.e. binge alcohol drinking) alters the way neurons and interneurons from the nucleus accumbens, a brain region responsible for alcohol rewarding properties, process information relevant to addiction.

We currently have two ongoing projects.

1-The first project focuses on the role played by nucleus accumbens cholinergic interneurons in mediating the effects of binge alcohol drinking on accumbens medium spiny neurons synaptic transmission.

2- The second project seeks to understand how nucleus accumbens medium spiny neurons, the only output neurons driving alcohol-related behavior, compute simultaneously emotional and cognitive information from the prelimbic cortical and basolateral amygdala regions in alcohol-naïve and binge alcohol drinking mice.

Techniques employed

To probe these questions at the cellular and behavioral levels, we combine a variety of techniques ranging from in vitro electrophysiological patch-clamp recording techniques in fresh slices of tissue, in vitro and in vivo optogenetic technique, behavioral assays, and in vivo imaging techniques.

 

One or more keywords matched the following items that are connected to Martin, Gilles
Item TypeName
Academic Article Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens.
Academic Article Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens.
Academic Article Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens.
Academic Article New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons.
Concept Nucleus Accumbens
Academic Article Large conductance voltage- and Ca2+-gated potassium (BK) channel ?4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases.
Academic Article BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons.
Academic Article The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens.
Academic Article The Sodium Channel ?4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons.
Academic Article Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity of the Core Nucleus Accumbens Direct and Indirect Pathways.
Academic Article Binge Alcohol Drinking Alters Synaptic Processing of Executive and Emotional Information in Core Nucleus Accumbens Medium Spiny Neurons.
Academic Article Binge alcohol drinking alters the differential control of cholinergic interneurons over nucleus accumbens D1 and D2 medium spiny neurons.
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  • Nucleus Accumbens