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One or more keywords matched the following properties of Ali, Akbar
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Targeting Drug Resistant Pathogens

We are interested in understanding the mechanisms of drug resistance and developing strategies to design inhibitors with improved resistance profiles. Our lab uses medicinal chemistry approaches to target drug-resistant pathogens such as HIV and HCV, flaviviruses, and cancers.

Research Focus

Drug resistance is a major limitation in the treatment of pathogenic infections and cancers. Understanding the molecular mechanisms of drug resistance and developing strategies to avoid resistance could lead to more effective therapies against drug resistant pathogens. Under the leadership of Prof. Celia Schiffer, we focus on optimizing the resistance profile of HIV and HCV protease inhibitors by SBDD, organic synthesis, and structure-activity relationship (SAR) studies. Our lab is also interested in using fragment-based drug design (FBDD) to discover inhibitors against dengue, zika and other Flavivirus proteases.

One or more keywords matched the following items that are connected to Ali, Akbar
Item TypeName
Academic Article Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.
Academic Article Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.
Academic Article Molecular Basis for Drug Resistance in HIV-1 Protease.
Academic Article Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Academic Article The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Academic Article Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.
Academic Article HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
Academic Article Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Concept Drug Resistance, Viral
Concept Drug Resistance, Multiple
Concept Drug Resistance, Multiple, Viral
Academic Article Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
Academic Article Testing the substrate-envelope hypothesis with designed pairs of compounds.
Academic Article Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article Structural analysis of asunaprevir resistance in HCV NS3/4A protease.
Academic Article Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.
Academic Article Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
Academic Article Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.
Academic Article Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Academic Article Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Academic Article Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
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  • Drug Resistance