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Nanomaterials for Neuroscience, Biomolecule Imaging and Therapy

email: gang.han@umassmed.edu

B.S. Nanjing University,Ph.D. University of Massachusetts-Amherst ,Postdoctoral Fellow. The Molecule Foundry, Lawrence Berkeley Lab. Phone: 508-856-3297

http://scholar.google.com/citations?user=zmGmLBoAAAAJ

My research is at the intersection between nanotechnology, neuroscience, bioimaging and therapy. We focus on developing both small and bright tools for biology, that is, designing synthetic/semi-synthetic nanomaterials or small molecules with unique programmable physical properties for basic science and biomedical applications.  These tools will be developed using a synergetic multidisciplinary approach, including synthetic chemistry, materials science, biochemistry, and cell biology.  In particular, we are most interested in developing optically active nanomaterials/molecules for probing signal transduction pathways, single-molecule imaging, sptiotemperol activation of neurons as well as diagnosis and drug delivery.

Contact: email: gang.han@umassmed.edu Phone : 508-856-3297

People in Lab:

Postdoctoral fellows:Yuanwei Zhang, Zhanjun Li, Jie Shen,  Graduate student: Xiang Wu,LWA/MQP student : Amol Punjabi, Hyungseok Alex Lee, George Han, Andrew Seto,  Rohit Maudgal

Alumni:

Postdoctoral fellows Yekui Zou (  2010- 2012, MIT)

Graduate students: Liang Zhao (2012 , Lecturer, Dalian University of Technology)

LWA students :Samuel J. Kesseli (2010-2013,  now MD student at Dartmouth Geisel School of Medicine)

Lucas J. Brutvan, (2011, Process Engineer at 3M),
Anne-Marie Vu (2013, Tufts University)
Steven Buchholz (2011, Product Analyst at Boston Scientific)

El-rifai, Mahmoud (2013-1014 Massachusetts Eye and Ear, Harvard Medical School), Amira Tokatli-Apollon(2013-2014  Design Assurance Engineer, HOLOGIC)

 Erin May Laroche; Rachael M. Matty; Babeu, Amy Monique; Cardoso, Marlisa Anne(2013 WPI)

Ayers, Brian Christopher (2013, MD/MBA Student - University of Rochester)

Luis Figueroa(2014, UMASS-Amherst)

Past rotation students: Xizhe Gao (2011, now Ph.D student at University of Maryland Baltimore School of Pharmacy), Artem Kutikov, (2011, Ph.D student at UMMS ), Lejie Zhang( 2013, Ph. D student at UMMS)

 

Rotation Projects

Rotation projects

(1) Specific cell membrane component labeling using bioconjugated nanoparticles

(2) To develop tools for targeted and traceable siRNA delivery

(3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids

One or more keywords matched the following items that are connected to Han, Gang
Item TypeName
Academic Article Tunable inhibition and denaturation of alpha-chymotrypsin with amino acid-functionalized gold nanoparticles.
Academic Article Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents.
Academic Article Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles.
Academic Article Mixed monolayer-protected gold nanoclusters as selective peptide extraction agents for MALDI-MS analysis.
Academic Article Reproducible, high-throughput synthesis of colloidal nanocrystals for optimization in multidimensional parameter space.
Academic Article Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione.
Academic Article Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers.
Academic Article DNA-binding by functionalized gold nanoparticles: mechanism and structural requirements.
Academic Article Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers.
Concept Nanostructures
Academic Article Upconverting NIR Photons for Bioimaging
Academic Article Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials.
Academic Article Upconverting NIR Photons for Bioimaging.
Academic Article Three-Dimensional Colloidal Controlled Growth of Core-Shell Heterostructured Persistent Luminescence Nanocrystals.
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  • Nanostructures