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Kornfeld, Hardy
One or more keywords matched the following properties of Kornfeld, Hardy
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overview

The Kornfeld Laboratory Link

Education

Medical School: Boston University School of Medicine, Boston, MA, 1978.
Medical Residency: University Hospital, Boston, MA, 1980.
St Luke's Hospital, NY, NY, 1981.
Infectious Disease Fellowship: St Luke's-Roosevelt Hospital Center, NY, NY, 1982.
Pulmonary Fellowship: Boston University School of Medicine, Boston, MA, 1985.
Molecular virology Fellowship: Harvard School of Public Health, Boston, MA, 1987.

Clinical, educational, scientific interests

Tuberculosis
Immunology
Host defense against respiratory pathogens
Impact of metabolic disorders on host defense
Critical care

Research Activities:

1. Role of macrophage apoptosis in TB defense
2. Impact of diabetes and hyperlipidemia on TB defense
3. Role of IL-16 in protective immunity
4. Heterologous immunity between viruses and mycobacteria
One or more keywords matched the following items that are connected to Kornfeld, Hardy
Item TypeName
Academic Article Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis.
Academic Article Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis.
Academic Article THP-1 cell apoptosis in response to Mycobacterial infection.
Academic Article Epitope-driven TB vaccine development: a streamlined approach using immuno-informatics, ELISpot assays, and HLA transgenic mice.
Academic Article Tuberculosis susceptibility of diabetic mice.
Academic Article Progress towards a genome-derived, epitope-driven vaccine for latent TB infection.
Academic Article Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database.
Academic Article Hypercholesterolemia impairs immunity to tuberculosis.
Academic Article Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence.
Academic Article Macrophage apoptosis in tuberculosis.
Academic Article Is hypercholesterolemia a friend or a foe of tuberculosis?
Academic Article Initiation of acquired immunity in the lungs of mice lacking lymph nodes after infection with aerosolized Mycobacterium tuberculosis.
Academic Article Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis.
Academic Article Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth.
Academic Article Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages.
Academic Article Interactions between na?ve and infected macrophages reduce Mycobacterium tuberculosis viability.
Academic Article Hypercholesterolemic LDL receptor-deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity.
Academic Article Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
Academic Article Impact of diabetes and smoking on mortality in tuberculosis.
Academic Article Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor.
Academic Article Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential.
Academic Article Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway.
Academic Article Intrathymic programming of effector fates in three molecularly distinct ?d T cell subtypes.
Academic Article Mannose-capped Lipoarabinomannan from Mycobacterium tuberculosis induces soluble tumor necrosis factor receptor production through tumor necrosis factor alpha-converting enzyme activation.
Academic Article Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells.
Academic Article Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo.
Concept Tuberculosis, Lymph Node
Concept Mycobacterium tuberculosis
Concept Latent Tuberculosis
Concept Tuberculosis, Pleural
Concept Tuberculosis
Concept Tuberculosis, Pulmonary
Concept Tuberculosis, Meningeal
Concept Tuberculosis Vaccines
Academic Article Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article Diabetes and immunity to tuberculosis.
Academic Article IP-10 and MIG are compartmentalized at the site of disease during pleural and meningeal tuberculosis and are decreased after antituberculosis treatment.
Academic Article Cell death and autophagy in tuberculosis.
Academic Article Bacillary replication and macrophage necrosis are determinants of neutrophil recruitment in tuberculosis.
Academic Article Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells.
Academic Article A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
Academic Article High Prevalence and Heterogeneity of Diabetes in Patients With TB in South India: A Report from the Effects of Diabetes on Tuberculosis Severity (EDOTS)?Study.
Academic Article Diabetes Is Associated with Worse Clinical Presentation in Tuberculosis Patients from Brazil: A Retrospective Cohort Study.
Academic Article An ounce of tuberculosis prevention.
Academic Article Effect of standard tuberculosis treatment on naive, memory and regulatory T-cell homeostasis in tuberculosis-diabetes co-morbidity.
Academic Article Glucose Metabolism Disorder Is Associated with Pulmonary Tuberculosis in Individuals with Respiratory Symptoms from Brazil.
Academic Article Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.
Academic Article Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors.
Academic Article Interferon-? Regulates the Death of M. tuberculosis-Infected Macrophages.
Academic Article NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection.
Academic Article Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice.
Academic Article Modulation of dendritic cell and monocyte subsets in tuberculosis-diabetes co-morbidity upon standard tuberculosis treatment.
Academic Article Defining a Research Agenda to Address the?Converging Epidemics of Tuberculosis and Diabetes: Part 1: Epidemiology and Clinical Management.
Academic Article Defining a Research Agenda to Address the?Converging Epidemics of Tuberculosis and Diabetes: Part 2: Underlying Biologic Mechanisms.
Academic Article "The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.
Academic Article Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications.
Academic Article Tuberculosis and lung damage: from epidemiology to pathophysiology.
Academic Article Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid.
Academic Article Elevated levels of matrix metalloproteinases reflect severity and extent of disease in tuberculosis-diabetes co-morbidity and are predominantly reversed following standard anti-tuberculosis or metformin treatment.
Academic Article Empirical treatment with non-anti-tuberculosis antibiotics decreased microbiological detection in cervical tuberculous lymphadenitis.
Academic Article Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co-morbidity.
Academic Article Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.
Academic Article Heightened circulating levels of antimicrobial peptides in tuberculosis-Diabetes co-morbidity and reversal upon treatment.
Academic Article Reduced prevalence of latent tuberculosis infection in diabetes patients using metformin and statins.
Academic Article Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity.
Academic Article mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis.
Academic Article Tuberculosis and diabetes: from bench to bedside and back.
Academic Article Heterogeneity in the cytokine profile of tuberculosis - diabetes co-morbidity.
Academic Article Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden.
Academic Article Plasma chemokines are biomarkers of disease severity, higher bacterial burden and delayed sputum culture conversion in pulmonary tuberculosis.
Academic Article Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy.
Academic Article Impact of Diabetes and Low Body Mass Index on Tuberculosis Treatment Outcomes.
Academic Article Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome.
Academic Article Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis.
Academic Article A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis.
Academic Article Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.
Academic Article Plasma Chemokines Are Baseline Predictors of Unfavorable Treatment Outcomes in Pulmonary Tuberculosis.
Academic Article Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits.
Academic Article Association of Plasma Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase Levels With Adverse Treatment Outcomes Among Patients With Pulmonary Tuberculosis.
Academic Article Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death.
Academic Article Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India.
Academic Article Effect of anti-tuberculosis treatment on the systemic levels of tissue inhibitors of metalloproteinases in tuberculosis - Diabetes co-morbidity.
Academic Article Pulmonary restriction predicts long-term pulmonary impairment in people with HIV and tuberculosis.
Academic Article Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study.
Academic Article Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure.
Academic Article Whole Genome Sequencing Assessing Impact of Diabetes Mellitus on Tuberculosis Mutations and Type of Recurrence in India.
Academic Article Heightened Microbial Translocation Is a Prognostic Biomarker of Recurrent Tuberculosis.
Academic Article Increased Risk of Incident Diabetes Among Individuals With Latent Tuberculosis Infection.
Academic Article Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis.
Academic Article Longitudinal trends in glycated hemoglobin during and after tuberculosis treatment.
Academic Article Chitinase and indoleamine 2, 3-dioxygenase are prognostic biomarkers for unfavorable treatment outcomes in pulmonary tuberculosis.
Academic Article A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction.
Academic Article Effect of prediabetes on tuberculosis treatment outcomes: A study from South India.
Academic Article Circulating Biomarkers, Fraction of Exhaled Nitric Oxide, and Lung Function in Patients With Human Immunodeficiency Virus and Tuberculosis.
Academic Article Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes.
Academic Article Distinct TB-antigen stimulated cytokine profiles as predictive biomarkers for unfavorable treatment outcomes in pulmonary tuberculosis.
Academic Article Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection-a Multicenter Prospective Cohort Analysis.
Academic Article Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India.
Academic Article Metformin reduces the risk of poor treatment outcomes among individuals with rifampicin-resistant tuberculosis and type-2 diabetes mellitus.
Academic Article Cytokine and chemokine profiles in pulmonary tuberculosis with pre-diabetes.
Search Criteria
  • Tuberculosis