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Search Results to Nathan Lawson PhD

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Academic Background

Nathan Lawson received his B.S. in Zoology from the University of Rhode Island in 1994, and his Ph.D. in Biology from Yale University in 1999. From 1999 to 2002, he was a National Research Council Postdoctoral Associate at the National Institutes of Health where he utilized the zebrafish to study developmental angiogenesis.  Dr. Lawson joined the Program in Gene Function and Expression at the University of Massachusetts Medical School as an Assistant Professor in the fall of 2002.

 

 

 

Developmental angiogenesis and the basis of endothelial heterogeneity

We utilize the zebrafish as a model system to understand how new blood vessel formation (angiogenesis) is coordinated and patterned in the developing embryo.  We also have an interest in the developmental basis of endothelial differentiation, which is essential to program blood vessel identity in distinct vascular beds in the mature animal.  We have also developed and applied cutting edge knockout technology to establish zebrafish models of vascular disease.  These include models in which deficient neurovascular formation leads to neurodegeneration, as well as models of congenital lymphedema.  These models will serve as excellent platforms for small molecule screens to identify compounds useful in the treatment of vascular diseases.  For more information, see our lab website at lawsonlab.umassmed.edu

 

Laboratory Personnel

For a current list of lab personnel, please visit our lab web page.


One or more keywords matched the following items that are connected to Lawson, Nathan

Item TypeName
Academic Article phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development.
Academic Article Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish.
Academic Article Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels.
Academic Article sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation.
Academic Article reg6 is required for branching morphogenesis during blood vessel regeneration in zebrafish caudal fins.
Academic Article The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney.
Academic Article pak2a mutations cause cerebral hemorrhage in redhead zebrafish.
Academic Article Gateway compatible vectors for analysis of gene function in the zebrafish.
Academic Article A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity.
Academic Article Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.
Academic Article Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites.
Academic Article miR-221 is required for endothelial tip cell behaviors during vascular development.
Academic Article A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.
Concept Embryo, Nonmammalian
Academic Article Distinct Notch signaling outputs pattern the developing arterial system.
Academic Article Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.

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  • Embryonic Structures