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Rotation Projects ?

Rotation Projects

Multiple rotation projects are available in several areas related to long-range gene regulation and higher order chromosome organization.  Projects include thorough analyses of the biochemical mechanisms of long-range gene regulation of specific disease-related genes, as well as large-scale analyses of chromosome organization using high-throughput genomics technologies (5C and Hi-C).  The lab employs a wide range of experimental approaches, including cell culture, protein biochemistry, microscopy, genomics as well computational approaches such as bioinformatics and modeling.  Specific rotation projects are determined dependent on the interest of the student.

One or more keywords matched the following items that are connected to Dekker, Job
Item TypeName
Academic Article Two regions within the DNA binding domain of nuclear factor I interact with DNA and stimulate adenovirus DNA replication independently.
Academic Article The three 'C' s of chromosome conformation capture: controls, controls, controls.
Academic Article The active FMR1 promoter is associated with a large domain of altered chromatin conformation with embedded local histone modifications.
Academic Article GC- and AT-rich chromatin domains differ in conformation and histone modification status and are differentially modulated by Rpd3p.
Academic Article Gene regulation in the third dimension.
Academic Article Integrating one-dimensional and three-dimensional maps of genomes.
Academic Article Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping.
Academic Article Genome architecture and expression.
Academic Article Spatial partitioning of the regulatory landscape of the X-inactivation centre.
Academic Article MORC family ATPases required for heterochromatin condensation and gene silencing.
Academic Article CTCF and cohesin help neurons raise their self-awareness.
Academic Article Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements.
Academic Article A mechanism for Ikaros regulation of human globin gene switching.
Academic Article Long-range chromosomal interactions and gene regulation.
Academic Article Mediator and cohesin connect gene expression and chromatin architecture.
Academic Article A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.
Academic Article A user's guide to the encyclopedia of DNA elements (ENCODE).
Academic Article The context of gene expression regulation.
Academic Article Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.
Academic Article The hierarchy of the 3D genome.
Academic Article Nuclear biology: what's been most surprising?
Academic Article Architectural protein subclasses shape 3D organization of genomes during lineage commitment.
Academic Article Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods?
Academic Article Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny.
Concept Gene Expression Regulation, Fungal
Concept Up-Regulation
Concept Gene Expression Regulation, Leukemic
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Viral
Concept Gene Expression Regulation, Neoplastic
Academic Article Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments.
Academic Article Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin.
Academic Article Condensin-driven remodelling of X chromosome topology during dosage compensation.
Academic Article Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells.
Academic Article Long-Range Chromatin Interactions.
Academic Article Structural and functional diversity of Topologically Associating Domains.
Academic Article Activation of proto-oncogenes by disruption of chromosome neighborhoods.
Academic Article TAD disruption as oncogenic driver.
Academic Article SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.
Academic Article RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
Academic Article CTCF-mediated topological boundaries during development foster appropriate gene regulation.
Academic Article Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation.
Academic Article Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
Academic Article C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.
Academic Article Corrigendum: CTCF-mediated topological boundaries during development foster appropriate gene regulation.
Academic Article Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
Academic Article Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.
Academic Article Detecting chromatin interactions between and along sister chromatids with SisterC.
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