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One or more keywords matched the following properties of Wang, Jennifer

Biographical Information

Post-graduate training

  • Internal Medicine Residency, Oregon Health Sciences University
  • Fellowship, Infectious Disease, University of California, San Diego

Board certification

  • Diplomate in Internal Medicine, American Board of Internal Medicine
  • Diplomate in Infectious Disease, American Board of Internal Medicine

Research interests

My research focuses on the evolution of influenza A virus under the selective pressure of antiviral drugs and antibodies using high-throughput sequencing. My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes.

One or more keywords matched the following items that are connected to Wang, Jennifer
Item TypeName
Academic Article Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus.
Academic Article Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.
Concept Antiviral Agents
Academic Article Dicer's role as an antiviral: still an enigma.
Academic Article Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.
Academic Article A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution.
Academic Article Remdesivir for the Treatment of Covid-19 - Final Report.
Academic Article Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.
Academic Article High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro.
Academic Article Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial.
Academic Article Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Academic Article Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Search Criteria
  • Antiviral Agents