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Wang, Jennifer

One or more keywords matched the following properties of Wang, Jennifer

Property	Value
overview	Biographical Information Post-graduate training Internal Medicine Residency, Oregon Health Sciences University Fellowship, Infectious Disease, University of California, San Diego Board certification Diplomate in Internal Medicine, American Board of Internal Medicine Diplomate in Infectious Disease, American Board of Internal Medicine Research interests My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes. Finally, we are examining drivers of inflammation in human stem cell-derived islets to better understand the pathogenesis of T1D.

Property

Value

overview

Biographical Information

Post-graduate training

Internal Medicine Residency, Oregon Health Sciences University
Fellowship, Infectious Disease, University of California, San Diego

Board certification

Diplomate in Internal Medicine, American Board of Internal Medicine
Diplomate in Infectious Disease, American Board of Internal Medicine

Research interests

My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes. Finally, we are examining drivers of inflammation in human stem cell-derived islets to better understand the pathogenesis of T1D.

One or more keywords matched the following items that are connected to Wang, Jennifer

Item Type	Name
Academic Article	The role of toll-like receptors in herpes simplex infection in neonates.
Academic Article	Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2.
Academic Article	Toll-like receptor-mediated activation of neutrophils by influenza A virus.
Academic Article	Antiviral responses: different roles for different tolls.
Academic Article	Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus.
Academic Article	Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
Academic Article	Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article	Toll like receptors and viruses.
Academic Article	Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
Academic Article	Innate immunity to respiratory viruses.
Academic Article	MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.
Academic Article	Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article	Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.
Concept	Virus Diseases
Concept	Viruses
Concept	Herpesvirus 2, Human
Concept	Influenza A Virus, H1N2 Subtype
Concept	Virus Replication
Concept	Influenza A Virus, H1N1 Subtype
Concept	Respiratory Syncytial Viruses
Concept	Herpesvirus 1, Human
Concept	Virus Internalization
Concept	West Nile virus
Concept	Hemagglutinin Glycoproteins, Influenza Virus
Concept	Parainfluenza Virus 3, Human
Concept	Dengue Virus
Concept	Influenza A Virus, H3N2 Subtype
Concept	Receptors, Virus
Concept	Reassortant Viruses
Concept	Herpesvirus 3, Human
Concept	Vesicular stomatitis Indiana virus
Concept	Rous sarcoma virus
Concept	Virus Activation
Concept	Encephalomyocarditis virus
Concept	Influenza A virus
Concept	Sendai virus
Academic Article	Influenza virus drug resistance: a time-sampled population genetics perspective.
Academic Article	TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
Academic Article	Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.
Academic Article	Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.
Academic Article	Influenza A virus preferentially snatches noncoding RNA caps.
Academic Article	A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article	An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy.
Academic Article	Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article	A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.
Academic Article	The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution.
Academic Article	Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Academic Article	Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.
Academic Article	Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.
Academic Article	A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.
Academic Article	The role of platelets in mediating a response to human influenza infection.
Academic Article	Viruses and the Lung. Fraire, Welsh, Kradin, and Woda (Eds.)
Academic Article	Autophagy and innate immunity to viruses
Academic Article	SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Academic Article	Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Academic Article	High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro.
Academic Article	Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2.
Academic Article	Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Academic Article	Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks.
Academic Article	Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases.
Academic Article	CRISPR editing of candidate host factors that impact influenza A virus infection.

Search Criteria

Herpesvirus 1 Cercopithecine