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One or more keywords matched the following properties of Wang, Jennifer
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Biographical Information

Post-graduate training

  • Internal Medicine Residency, Oregon Health Sciences University
  • Fellowship, Infectious Disease, University of California, San Diego

Board certification

  • Diplomate in Internal Medicine, American Board of Internal Medicine
  • Diplomate in Infectious Disease, American Board of Internal Medicine

Research interests

My research focuses on the evolution of influenza A virus under the selective pressure of antiviral drugs and antibodies using high-throughput sequencing. My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes.

One or more keywords matched the following items that are connected to Wang, Jennifer
Item TypeName
Academic Article Toll-like receptor-mediated activation of neutrophils by influenza A virus.
Academic Article Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus.
Academic Article Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro.
Concept Influenza A Virus, H1N2 Subtype
Concept Influenza A Virus, H1N1 Subtype
Concept Influenza, Human
Concept Hemagglutinin Glycoproteins, Influenza Virus
Concept Influenza A Virus, H3N2 Subtype
Concept Influenza Vaccines
Concept Influenza A virus
Academic Article Influenza virus drug resistance: a time-sampled population genetics perspective.
Academic Article Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.
Academic Article Influenza A virus preferentially snatches noncoding RNA caps.
Academic Article A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy.
Academic Article Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution.
Academic Article Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Academic Article Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.
Academic Article Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.
Academic Article The role of platelets in mediating a response to human influenza infection.
Academic Article SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Academic Article Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study.
Academic Article Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Academic Article High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro.
Academic Article Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2.
Academic Article Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Academic Article Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks.
Academic Article Dysregulated pulmonary inflammatory responses exacerbate the outcome of secondary aspergillosis following influenza.
Academic Article CRISPR editing of candidate host factors that impact influenza A virus infection
Search Criteria
  • Influenza Human