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One or more keywords matched the following properties of Wang, Jennifer

Biographical Information

Post-graduate training

  • Internal Medicine Residency, Oregon Health Sciences University
  • Fellowship, Infectious Disease, University of California, San Diego

Board certification

  • Diplomate in Internal Medicine, American Board of Internal Medicine
  • Diplomate in Infectious Disease, American Board of Internal Medicine

Research interests

My research focuses on the evolution of influenza A virus under the selective pressure of antiviral drugs and antibodies using high-throughput sequencing. My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes.

One or more keywords matched the following items that are connected to Wang, Jennifer
Item TypeName
Academic Article The role of toll-like receptors in herpes simplex infection in neonates.
Academic Article Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2.
Academic Article Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA.
Academic Article Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides.
Academic Article Toll-like receptor-mediated activation of neutrophils by influenza A virus.
Academic Article Antiviral responses: different roles for different tolls.
Academic Article Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists.
Academic Article Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
Academic Article Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article Toll like receptors and viruses.
Academic Article Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA.
Academic Article Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans.
Academic Article Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article Plasmacytoid dendritic cell interferon-? production to R-848 stimulation is decreased in male infants.
Concept Toll-Like Receptors
Concept Toll-Like Receptor 4
Concept Toll-Like Receptor 9
Concept Toll-Like Receptor 2
Concept Toll-Like Receptor 7
Concept Toll-Like Receptor 8
Academic Article The role of platelets in mediating a response to human influenza infection.
Search Criteria
  • Toll Like Receptors