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Mercurio, Arthur
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Rotation Projects

Rotation Projects

Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include:

Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer

  • Epigenetic mechanisms that regulate integrin gene expression in human cancers
  • Regulation of integrin expression and function during the EMT
  • Role of specfic microRNAs (miRs) in regulating integrin function and signaling
  • Contribution of integrins to carcinoma progression using mouse models of breast carcinoma

Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression

  • Function and expression of VEGF receptors in carcinoma cells
  • Regulation of VEGF transcription in response to EMT stimuli
  • Role of miRs in regulating VEGF receptors and signaling
  • Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas

Nuclear Hormone Receptors and EMT

  • Role of estrogen receptors in regulating the EMT
  • Regulation of VEGF transcription by estrogen receptors
One or more keywords matched the following items that are connected to Mercurio, Arthur
Item TypeName
Academic Article Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells.
Academic Article Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.
Academic Article Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.
Academic Article The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion.
Academic Article Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells.
Academic Article The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis.
Academic Article Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.
Academic Article Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells.
Academic Article The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function.
Academic Article The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis.
Academic Article Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells.
Academic Article Transcriptional regulation of VEGF-A by the unfolded protein response pathway.
Academic Article Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland.
Academic Article Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology.
Academic Article Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
Academic Article Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin ?4.
Academic Article VEGF targets the tumour cell.
Academic Article Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.
Academic Article Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids.
Academic Article E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers.
Academic Article Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin.
Academic Article Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes.
Academic Article Contributions of the alpha6 integrins to breast carcinoma survival and progression.
Academic Article Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma.
Academic Article The epithelial-mesenchymal transition (EMT) and colorectal cancer progression.
Academic Article The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo.
Academic Article Non-angiogenic functions of VEGF in breast cancer.
Academic Article Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition.
Academic Article ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.
Academic Article Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells.
Academic Article VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.
Academic Article Estrogen receptor ? sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.
Concept Vascular Endothelial Growth Factor A
Concept Transforming Growth Factor beta
Concept Vascular Endothelial Growth Factor Receptor-1
Concept Eukaryotic Initiation Factor-4E
Concept Receptor, Platelet-Derived Growth Factor beta
Concept Platelet-Derived Growth Factor
Concept STAT3 Transcription Factor
Concept Receptors, Growth Factor
Concept Hypoxia-Inducible Factor 1
Concept Tumor Necrosis Factor-alpha
Concept Activating Transcription Factor 6
Concept Transforming Growth Factor beta1
Concept Hepatocyte Growth Factor
Concept Vascular Endothelial Growth Factor C
Concept Transcription Factor AP-1
Concept Receptors, Tumor Necrosis Factor, Member 25
Concept Eukaryotic Initiation Factor-4F
Concept NF-E2-Related Factor 2
Concept Epidermal Growth Factor
Concept Receptors, Tumor Necrosis Factor
Concept Receptors, Vascular Endothelial Growth Factor
Concept Transcription Factor RelA
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Academic Article Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.
Academic Article Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.
Academic Article ER? regulation of NF-kB activation in prostate cancer is mediated by HIF-1.
Academic Article Tead and AP1 Coordinate Transcription and Motility.
Academic Article P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ?2-chimaerin.
Academic Article The a6?4 integrin promotes resistance to ferroptosis.
Academic Article Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology.
Academic Article VEGF/Neuropilin Signaling in Cancer Stem Cells.
Academic Article The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.
Academic Article Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis.
Concept Regulatory Factor X Transcription Factors
Concept Hypoxia-Inducible Factor-Proline Dioxygenases
Academic Article Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer.
Academic Article Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Academic Article Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling.
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