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Mercurio, Arthur
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Rotation Projects

Rotation Projects

Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include:

Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer

  • Epigenetic mechanisms that regulate integrin gene expression in human cancers
  • Regulation of integrin expression and function during the EMT
  • Role of specfic microRNAs (miRs) in regulating integrin function and signaling
  • Contribution of integrins to carcinoma progression using mouse models of breast carcinoma

Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression

  • Function and expression of VEGF receptors in carcinoma cells
  • Regulation of VEGF transcription in response to EMT stimuli
  • Role of miRs in regulating VEGF receptors and signaling
  • Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas

Nuclear Hormone Receptors and EMT

  • Role of estrogen receptors in regulating the EMT
  • Regulation of VEGF transcription by estrogen receptors
One or more keywords matched the following items that are connected to Mercurio, Arthur
Item TypeName
Academic Article Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells.
Academic Article Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.
Academic Article Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.
Academic Article Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells.
Academic Article Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.
Academic Article Transcriptional regulation of VEGF-A by the unfolded protein response pathway.
Academic Article Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland.
Academic Article Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology.
Academic Article Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
Academic Article VEGF targets the tumour cell.
Academic Article Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids.
Academic Article Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin.
Academic Article Contributions of the alpha6 integrins to breast carcinoma survival and progression.
Academic Article The epithelial-mesenchymal transition (EMT) and colorectal cancer progression.
Academic Article The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo.
Academic Article Non-angiogenic functions of VEGF in breast cancer.
Academic Article ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.
Academic Article VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.
Concept Vascular Endothelial Growth Factor A
Concept Vascular Endothelial Growth Factor Receptor-1
Concept Vascular Endothelial Growth Factors
Concept Vascular Endothelial Growth Factor C
Concept Endothelial Growth Factors
Concept Receptors, Vascular Endothelial Growth Factor
Academic Article Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.
Academic Article Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.
Academic Article P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ?2-chimaerin.
Academic Article Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology.
Academic Article VEGF/Neuropilin Signaling in Cancer Stem Cells.
Academic Article The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.
Academic Article Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer.
Academic Article Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Academic Article Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling.
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  • Endothelial Growth Factors