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Arthur Mercurio received his B.S. in Biochemistry from Rutgers University in 1975 and a Ph.D. in Cell Biology from Columbia University in 1981. He was a Postdoctoral Fellow in the Center for Cancer Research at M.I.T. from 1981-1985. In 1986, he joined the faculty at Harvard Medical School and the Beth Israel Deaconess Medical Center. He was the Director of the Division of Cancer Biology and Angiogenesis at BIDMC until 2005 when he became Vice Chairman of the Department of Cancer Biology at the University of Massachusetts Medical School and Interim Chair in 2010. Dr. Mercurio is a recipient of the American Cancer Society Junior Faculty and Faculty Research Awards, and he was an Honorary Professor at the University of Copenhagen.


We are interested in the initiation and progression of epithelial-derived tumors (carcinomas), especially aggressive, poorly differentiated tumors. Our research projects emphasize molecular cell biology but they derive from the analysis and clinical behavior of carcinomas. Our goal is to identify mechanisms that account for the loss of differentiation and the highly aggressive behavior of these tumors, and to exploit these mechanisms to improve prognosis and therapy. Ongoing projects in the lab include studies on:

Regulation and Function of Integrins

The lab has a long-standing interest in the a6 integrins (a6ß1 and a6ß4). These integrins have pivotal roles in the biology of carcinomas as demonstrated by our work and that of others. The a6ß1 integrin (CD49f) is an established marker for many populations of tumor stem/initiating cells including those present in breast and prostate carcinomas and it is essential for the function of these cells. Current studies on a6ß1 involve its regulation by Neuropilin-2 and VEGF signaling (see below) and elucidating the mechanism by which it contributes to the function of tumor stem/initiating cells. We are continuing our studies on the integrin a6ß4 (referred to as ‘ß4 integrin’) in this context. The primary function of this integrin, which is expressed on the basal surface of most epithelia, is to anchor the epithelium to laminins in the basement membrane and maintain epithelial integrity. Our lab pioneered studies that established that this integrin also plays a significant role in functions associated with carcinoma progression, including migration, invasion and survival, and that it is often expressed in poorly differentiated carcinomas. What has emerged from these studies is the premise that the ß4 integrin plays a dominant role in progression through its ability to influence other receptors and key signaling pathways. Given these findings and their implications, current projects are assessing mechanisms that regulate ß4 integrin gene expression in human cancers, the role of specific microRNAs in regulating ß4 integrin function and signaling and the contribution of ß4 integrin to epithelial biology and carcinoma progression using mouse models of specific carcinomas.

VEGF Function and Signaling in Carcinoma Cells

This project is based on the hypothesis that VEGF receptors expressed on carcinoma cells mediate VEGF signaling and that VEGF signaling in epithelial cells contributes to tumor initiation. This hypothesis challenges the notion that the function of VEGF in cancer is limited to angiogenesis and that therapeutic approaches based on the inhibition of VEGF and its receptors target only angiogenesis. We are most interested in a specific class of VEGF receptors termed the neuropilins (NRPs). NRP1 and NRP2 were identified initially as neuronal receptors for semaphorins, but they also function as VEGF receptors on tumor cells. We are particularly interested in NRP2 because our recent findings indicate that its contribution to breast tumorigenesis is significant. NRP2 expression correlates with progression and poor outcome in women with breast cancer, and its expression is associated with aggressive, triple-negative breast cancers. Moreover, our data indicate that NRP2 expression is induced by oncogenic stimuli that promote mammary tumor formation and they suggest that it has a causal role in tumorigenesis. We also discovered that NRP2 is highly enriched in tumor-initiating cells isolated from triple-negative tumors and that it can regulate the function of the a6ß1 integrin (CD49f), a marker of tumor-initiating cells. An important implication of our findings is that NRP2 is a prime target for therapeutic intervention, a highly feasible possibility because function-blocking antibodies are available for clinical trials. This issue is timely because the FDA has recommended discontinuing the use of Avastin (bevacizumab) for treating breast cancer because it has not been shown to be effective. Bevacizumab, however, does not inhibit the VEGF/NRP2 interaction, strengthening the rationale for targeting NRP2 directly. Based on existing data, we postulate that VEGF/NRP2 signaling cooperates with oncogenic stimuli to drive the formation of breast cancers by promoting the functions of tumor-initiating cells, especially the function and signaling properties of the a6ß1 integrin.

We are also pursuing the contribution of VEGF/NRP2 to prostate cancer. This project is based on our novel findings that PTEN deletion induces JNK/Jun-dependent NRP2 expression, NRP2 contributes to the growth of PTEN-null prostate carcinoma cells in soft agar and as xenografts, and NRP2 expression correlates with Gleason grade. The role of VEGF/NRP2 signaling in prostate tumorigenesis can be explained by our exciting discovery that NRP2 facilitates the expression of Bmi-1, a transcriptional repressor that has a critical role in the function of prostate stem and tumor initiating cells. We have also shown that NRP2 suppresses the IGF-1 receptor (IGF-1R) by a mechanism that involves transcriptional repression by Bmi-1 and, as a consequence, confers resistance to IGF-1R therapy of prostate carcinoma. In fact, we have found that NRP2 expressing prostate tumors are resistant to IGF-1R therapy. This hypothesis is significant because several IGF-1R inhibitors are in clinical trials but the mechanisms to account for patient response to these inhibitors are largely unknown. Given that clinical trials of the VEGF Ab bevacizumab have been disappointing, we are targeting NRP2 directly on tumor cells in combination with IGF-1R inhibition as a novel and a potentially potent approach for treating prostate carcinoma.

Regulation of Epithelial Fate and Carcinoma Differentiation by Estrogen Receptors
We are interested in the hypothesis that ligand-dependent activation of estrogen receptors (either ERa or ß) sustains epithelial differentiation and that loss of this activation in carcinomas contributes to a more de-differentiated, aggressive phenotype. This hypothesis is supported by the observation that ERa-negative breast carcinomas are typically less differentiated and more aggressive than ERa-positive tumors. Also, the loss of ERß in high-grade prostate carcinomas is also linked to de-differentiation and highly invasive behavior. We reported that a key function of ERß and its specific ligand 5a-androstane-3ß,17ß-diol (3ß-adiol) is to maintain an epithelial phenotype and repress mesenchymal characteristics in prostate carcinoma. The mechanism involves ERß-mediated destabilization of HIF-1a and transcriptional repression of HIF-1 target genes including VEGF-A. This mechanism is extremely important and relevant because we demonstrated that high Gleason grade tumors exhibit significantly elevated expression of HIF-1a but clinically relevant hypoxia is not seen in localized primary prostate cancer including high-grade tumors. These observations indicate that loss of ERß in prostate cancer mimics hypoxia by stabilizing HIF-1a. The mechanism by which ERß destabilizes HIF-1a is under investigation and we hypothesize that this mechanism is critical for maintaining an epithelial state and preventing a mesenchymal transition. The loss of ERß that characterizes high-grade, aggressive prostate cancer results in increased VEGF expression in tumor cells and consequent autocrine VEGF/NRP2 signaling as described above.

RNA Binding Proteins in Aggressive Carcinomas
This project is based on the finding that the expression of IGFII mRNA-binding protein 3 (IMP3) is associated with highly aggressive cancers, including triple-negative breast carcinomas. We are pursuing the hypothesis that IMP3 has an essential role in maintaining a de-differentiated state characteristic of high-grade tumors and that it functions in this capacity by interacting with and facilitating the expression of specific mRNAs whose proteins products promote epithelial de-differentiation.

Rotation Projects

Rotation Projects

Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include:

Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer

  • Epigenetic mechanisms that regulate integrin gene expression in human cancers
  • Regulation of integrin expression and function during the EMT
  • Role of specfic microRNAs (miRs) in regulating integrin function and signaling
  • Contribution of integrins to carcinoma progression using mouse models of breast carcinoma

Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression

  • Function and expression of VEGF receptors in carcinoma cells
  • Regulation of VEGF transcription in response to EMT stimuli
  • Role of miRs in regulating VEGF receptors and signaling
  • Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas

Nuclear Hormone Receptors and EMT

  • Role of estrogen receptors in regulating the EMT
  • Regulation of VEGF transcription by estrogen receptors
One or more keywords matched the following items that are connected to Mercurio, Arthur
Item TypeName
Academic Article Function of the integrin alpha 6 beta 1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor.
Academic Article The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures.
Academic Article Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion.
Academic Article Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells.
Academic Article Endothelial cells assemble two distinct alpha6beta4-containing vimentin-associated structures: roles for ligand binding and the beta4 cytoplasmic tail.
Academic Article Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells.
Academic Article Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing.
Academic Article Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion.
Academic Article A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells.
Academic Article Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin.
Academic Article The metastatic odyssey: the integrin connection.
Academic Article Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium.
Academic Article Integrin signaling in leukocytes: lessons from the alpha6beta1 integrin.
Academic Article Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells.
Academic Article The integrin alpha 6 beta 4 and the biology of carcinoma.
Academic Article Integrin laminin receptors and breast carcinoma progression.
Academic Article The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice.
Academic Article Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit.
Academic Article Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells.
Academic Article Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.
Academic Article ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
Academic Article Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way.
Academic Article ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.
Academic Article Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM.
Academic Article Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.
Academic Article Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells.
Academic Article Laminin receptors: achieving specificity through cooperation.
Academic Article The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion.
Academic Article Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells.
Academic Article Activation of p53 function in carcinoma cells by the alpha6beta4 integrin.
Academic Article The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis.
Academic Article Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.
Academic Article Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells.
Academic Article The integrin alpha 6 beta 4 is a laminin receptor.
Academic Article p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB.
Academic Article Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.
Academic Article A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
Academic Article RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism.
Academic Article Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins.
Academic Article Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma.
Academic Article Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells.
Academic Article The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.
Academic Article Laminin: multiple forms, multiple receptors.
Academic Article The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function.
Academic Article The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis.
Academic Article PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B.
Academic Article Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Academic Article Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1.
Academic Article The alpha 6 beta 4 integrin and epithelial cell migration.
Academic Article Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells.
Academic Article Notes on the heterogeneity, circulation, and modification of membranes, with emphasis on secretory cells, photoreceptors, and the toad bladder.
Academic Article Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion.
Academic Article Interferon gamma and lipopolysaccharide promote macrophage adherence to basement membrane glycoproteins.
Academic Article miR-10b targets Tiam1: implications for Rac activation and carcinoma migration.
Academic Article Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland.
Academic Article ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
Academic Article Role of JNK in mammary gland development and breast cancer.
Academic Article Regulation of IMP3 by EGFR signaling and repression by ER?: implications for triple-negative breast cancer.
Academic Article Integrin ?4 regulates SPARC protein to promote invasion.
Academic Article Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology.
Academic Article Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
Academic Article Disruption of oligosaccharide processing in murine tumor cells inhibits their susceptibility to lysis by activated mouse macrophages.
Academic Article GLI1 regulates a novel neuropilin-2/?6?1 integrin based autocrine pathway that contributes to breast cancer initiation.
Academic Article IMP3 protein promotes chemoresistance in breast cancer cells by regulating breast cancer resistance protein (ABCG2) expression.
Academic Article Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin ?4.
Academic Article VEGF targets the tumour cell.
Academic Article Modulation of two distinct galactosyltransferase activities in populations of mouse peritoneal macrophages.
Academic Article Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.
Academic Article Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids.
Academic Article Carbohydrate-binding protein 35 is the major cell-surface laminin-binding protein in colon carcinoma.
Academic Article Membrane circulation in neurons and photoreceptors: some unresolved issues.
Academic Article Ultrastructural localization of glycerolipid synthesis in rod cells of the isolated frog retina.
Academic Article Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells.
Academic Article E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers.
Academic Article Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain.
Academic Article Proteases, extracellular matrix, and cancer: a workshop of the path B study section.
Academic Article Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength.
Academic Article A novel structural variant of the human beta 4 integrin cDNA.
Academic Article Fimbrin localized to an insoluble cytoskeletal fraction is constitutively phosphorylated on its headpiece domain in adherent macrophages.
Academic Article Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit.
Academic Article Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes.
Academic Article Contributions of the alpha6 integrins to breast carcinoma survival and progression.
Academic Article Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma.
Academic Article Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition.
Academic Article Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.
Academic Article Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease.
Academic Article The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo.
Academic Article Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells.
Academic Article Intrinsic signaling functions of the beta4 integrin intracellular domain.
Academic Article Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition.
Academic Article IAP regulation of metastasis.
Academic Article ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.
Academic Article IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer.
Academic Article Neuropilin-2 regulates ?6?1 integrin in the formation of focal adhesions and signaling.
Academic Article Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells.
Academic Article VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.
Academic Article Relationship between extracellular matrix interactions and degree of differentiation in human colon carcinoma cell lines.
Academic Article Interactions of human colorectal carcinoma cells with basement membranes. Analysis and correlation with differentiation.
Academic Article Estrogen receptor ? sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.
Academic Article Macrophage interactions with laminin: PMA selectively induces the adherence and spreading of mouse macrophages on a laminin substratum.
Academic Article Laminin expression in colorectal carcinomas varying in degree of differentiation.
Academic Article Smooth endoplasmic reticulum and other agranular reticulum in frog retinal photoreceptors.
Academic Article Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma.
Academic Article The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins.
Academic Article Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor.
Academic Article Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.
Academic Article Integrin alpha 6 beta 4 mediates dynamic interactions with laminin.
Academic Article Regulation of alpha 6 beta 1 integrin-mediated migration in macrophages.
Academic Article Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?
Academic Article Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.
Academic Article Poorly differentiated colon carcinoma cell lines deficient in alpha-catenin expression express high levels of surface E-cadherin but lack Ca(2+)-dependent cell-cell adhesion.
Academic Article Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line.
Concept Cell Fusion
Concept Epithelial Cells
Concept Neoplastic Stem Cells
Concept HeLa Cells
Concept Cell Nucleus
Concept Cell Division
Concept COS Cells
Concept Cell Communication
Concept Carcinoma, Basal Cell
Concept Cell Adhesion Molecules
Concept Cell Survival
Concept Receptors, Cell Surface
Concept Cell Adhesion
Concept 3T3-L1 Cells
Concept NIH 3T3 Cells
Concept Cell Cycle Proteins
Concept Endothelial Cells
Concept Cell Aggregation
Concept CHO Cells
Concept 3T3 Cells
Concept Tumor Cells, Cultured
Concept Cell Differentiation
Concept Cell Line, Transformed
Concept Cell Polarity
Concept Neoplasms, Squamous Cell
Concept Cell Movement
Concept Cells, Cultured
Concept Stem Cells
Concept Cell Hypoxia
Concept Cell Separation
Concept Rod Cell Outer Segment
Concept Cell Proliferation
Concept Cell Cycle
Concept Cell Membrane
Concept Cell Culture Techniques
Concept Cell Transdifferentiation
Concept Clone Cells
Concept Cell Transformation, Neoplastic
Concept Carcinoma, Squamous Cell
Concept Neoplastic Cells, Circulating
Concept Photoreceptor Cells
Concept Cell Size
Concept Stromal Cells
Concept Cell Growth Processes
Concept Cell Line
Concept Cell Compartmentation
Concept Cell Line, Tumor
Academic Article Regulated splicing of the ?6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.
Academic Article Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin ?4.
Academic Article A cell-ECM screening method to predict breast cancer metastasis.
Academic Article A laminin 511 matrix is regulated by TAZ and functions as the ligand for the ?6B?1 integrin to sustain breast cancer stem cells.
Academic Article Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor ? repression.
Academic Article IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.
Academic Article ER? regulation of NF-kB activation in prostate cancer is mediated by HIF-1.
Academic Article Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells.
Academic Article Tead and AP1 Coordinate Transcription and Motility.
Academic Article P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine.
Academic Article VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ?2-chimaerin.
Academic Article IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer.
Academic Article Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays.
Academic Article The ?6?4 integrin promotes resistance to ferroptosis.
Academic Article Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology.
Academic Article Cell clustering mediated by the adhesion protein PVRL4 is necessary for ?6?4 integrin-promoted ferroptosis resistance in matrix-detached cells.
Academic Article VEGF/Neuropilin Signaling in Cancer Stem Cells.
Academic Article CD44 splice isoform switching determines breast cancer stem cell state.
Academic Article The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.
Academic Article Real-time imaging of integrin ?4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing.
Academic Article Alveolar progenitor cells in the mammary gland are dependent on the ?4 integrin.
Academic Article Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export.
Academic Article Tumor cell-organized fibronectin maintenance of a dormant breast cancer population.
Academic Article Ferroptosis resistance mediated by exosomal release of iron.
Academic Article Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering.
Academic Article Protocol for the separation of extracellular vesicles by ultracentrifugation from in vitro cell culture models.
Academic Article O-linked ?2,3 sialylation defines stem cell populations in breast cancer.
Concept HEK293 Cells
Concept Human Umbilical Vein Endothelial Cells
Concept MCF-7 Cells
Academic Article PD-LI promotes rear retraction during persistent cell migration by altering integrin ?4 dynamics.
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