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One or more keywords matched the following properties of Bogdanov, Alexei
keywords Magnetic Resonance Imaging
keywords molecular imaging
keywords imaging probe


Molecular imaging probes and relevance of our research. Microscopy of tissue samples has traditionally been one of the mainstays of experimental biology. However, advances in our understanding of the biochemical basis of disease has made it desirable and even necessary to be able to image these changes as they happen in vivo, using techniques which are noninvasive. The goal of such techniques are several fold:1) to obtain, analyze, and monitor disease related changes in molecular physiology over time and with high spatial resolution, i.e., up to the level of individual cells,2) to simultaneously acquire highly accurate anatomical images (tissue mapping) while mapping the functional status of tissues and organs, and3) to allow fundamental research findings to be translated into clinically diagnostic imaging strategies.Towards this end, ‘molecular imaging’ utilizes signals from endogenous or exogenous (chemically engeneered) substrates to probe chemical reactions in living cells. Such ‘reporters’ or ‘sensors’ have been successfully used to track real time changes in molecular physiology using modern diagnostic imaging methods such as magnetic resonance imaging (MRI), positron emission tomography (PET), gamma scintigraphy, optical fluorescence and near-infrared imaging, to relate these changes to the initiation and progression of diseases such as atherosclerosis and cancer. In order to gain wide-spread use in a clinical setting, molecular probes must be biocompatible, easily administered, specific and effective at low dosages.Our research addresses the issue of increasing selectivity and sensitivity of imaging probes. We also apply this research in realistic models of diseases.

One or more keywords matched the following items that are connected to Bogdanov, Alexei
Item TypeName
Award or Honor Receipt Academy of Molecular Imaging Top Scientific Abstract Award
Academic Article Magnetically labeled cells can be detected by MR imaging.
Academic Article Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages.
Academic Article The development of in vivo imaging systems to study gene expression.
Academic Article Mapping the in vivo distribution of herpes simplex virions.
Academic Article Near-infrared optical imaging of protease activity for tumor detection.
Academic Article Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model.
Academic Article Magnetically labeled secretin retains receptor affinity to pancreas acinar cells.
Academic Article MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis.
Academic Article Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study.
Academic Article Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging.
Academic Article DNA binding chelates for nonviral gene delivery imaging.
Academic Article MR imaging and scintigraphy of gene expression through melanin induction.
Academic Article Relative blood volume measurements by magnetic resonance imaging facilitate detection of testicular torsion.
Academic Article In vivo localization of diglycylcysteine-bearing synthetic peptides by nuclear imaging of oxotechnetate transchelation.
Academic Article MR imaging of gene delivery to the central nervous system with an artificial vector.
Academic Article Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging.
Academic Article Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction.
Academic Article Near-infrared fluorescent imaging of tumor apoptosis.
Academic Article Mechanism of gadophrin-2 accumulation in tumor necrosis.
Academic Article Engineering of technetium-99m-binding artificial receptors for imaging gene expression.
Academic Article In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.
Academic Article In vivo imaging in the development of gene therapy vectors.
Academic Article Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
Academic Article Measurement of tumor interstitial volume fraction: method and implication for drug delivery.
Academic Article Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis.
Academic Article Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension.
Academic Article Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model.
Academic Article Myeloperoxidase activity imaging using (67)Ga labeled substrate.
Academic Article Drug targeting in magnetic resonance imaging.
Academic Article Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.
Academic Article New approaches for imaging in gene therapy.
Academic Article [Imaging of angiogenesis].
Academic Article Amplification strategies in MR imaging: activation and accumulation of sensing contrast agents (SCAs).
Academic Article Synthesis and testing of a binary catalytic system for imaging of signal amplification in vivo.
Academic Article A paramagnetic contrast agent for detecting tyrosinase activity.
Academic Article Environment-sensitive and enzyme-sensitive MR contrast agents.
Academic Article Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study.
Academic Article Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture.
Academic Article Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.
Academic Article Molecular magnetic resonance contrast agents for the detection of cancer: past and present.
Academic Article Hairpin-like fluorescent probe for imaging of NF-?B transcription factor activity.
Academic Article Imaging the pancreatic vasculature in diabetes models.
Academic Article A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo.
Academic Article Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging.
Academic Article Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study.
Academic Article Viral imaging in gene therapy noninvasive demonstration of gene delivery and expression.
Academic Article Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy.
Academic Article Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.
Academic Article Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets.
Academic Article Synthetic copolymer kit for radionuclide blood-pool imaging.
Academic Article MR lymphography: study of a high-efficiency lymphotrophic agent.
Academic Article Detection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits.
Academic Article AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy.
Academic Article Polymeric contrast agents for MR imaging of adrenal glands.
Academic Article A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies.
Academic Article Magnetic resonance signal amplification probes.
Academic Article DTPA-bisamide-based MR sensor agents for peroxidase imaging.
Academic Article Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis.
Academic Article Detection of early antiangiogenic effects in human colon adenocarcinoma xenografts: in vivo changes of tumor blood volume in response to experimental VEGFR tyrosine kinase inhibitor.
Academic Article Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer.
Academic Article A paramagnetic contrast agent with myeloperoxidase-sensing properties.
Academic Article Imaging molecular expression on vascular endothelial cells by in vivo immunofluorescence microscopy.
Academic Article Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model.
Academic Article Optical imaging of the adoptive transfer of human endothelial cells in mice using anti-human CD31 monoclonal antibody.
Academic Article Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes.
Academic Article In vivo quantification of transvascular water exchange during the acute phase of permanent stroke.
Academic Article Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.
Academic Article In vitro and In vivo imaging of antivasculogenesis induced by Noggin protein expression in human venous endothelial cells.
Academic Article Orthotopic expression of noggin protein in cancer cells inhibits human lung carcinoma growth in vivo.
Academic Article In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium.
Academic Article Protected Graft Copolymer (PGC) in Imaging and Therapy: A Platform for the Delivery of Covalently and Non-Covalently Bound Drugs.
Academic Article Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer.
Academic Article Determinants of in vivo MR imaging of slow axonal transport.
Academic Article MION-ASF: biokinetics of an MR receptor agent.
Academic Article Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy.
Academic Article Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging.
Academic Article MR imaging of slow axonal transport in vivo.
Academic Article Monocrystalline iron oxide nanocompounds (MION): physicochemical properties.
Concept Molecular Imaging
Concept Diagnostic Imaging
Concept Gated Blood-Pool Imaging
Concept Radionuclide Imaging
Concept Echo-Planar Imaging
Concept Phantoms, Imaging
Academic Article MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model.
Academic Article Liposome-encapsulated superoxide dismutase mimetic: theranostic potential of an MR detectable and neuroprotective agent.
Academic Article Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO2 challenges in mouse brain.
Academic Article MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall.
Academic Article Imaging Inflammation in Cerebrovascular Disease.
Academic Article Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging.
Award or Honor Receipt Fellow
Grant Molecular Imaging Probes for Reporting on Vascular Oxidative Response
Grant Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging
Academic Article Fluorocarbons Enhance Intracellular Delivery of Short STAT3-sensors and Enable Specific Imaging.
Academic Article Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model.
Academic Article High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease.
Academic Article Substrate-based near-infrared imaging sensors enable fluorescence lifetime contrast via built-in dynamic fluorescence quenching elements.
Academic Article 19F MRI of Polymer Nanogels Aided by Improved Segmental Mobility of Embedded Fluorine Moieties.
Academic Article Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human Diseases.
Academic Article Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation.
Academic Article Imaging NF-?B activity in a murine model of early stage diabetes.
Academic Article Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms.
Grant MR Signal Amplification for Receptor Imaging
Academic Article Magnetic resonance contrast agents in optical clearing: Prospects for multimodal tissue imaging.
Academic Article In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.
Academic Article Multimodal Bone Metastasis-associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model.
Concept Optical Imaging
Concept Multimodal Imaging
Academic Article MR and fluorescence imaging of gadobutrol-induced optical clearing of red fluorescent protein signal in an in vivo cancer model.
Academic Article Molecular Magnetic Resonance Imaging of Aneurysmal Inflammation Using a Redox Active Iron Complex.
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  • Imaging Three Dimensional