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One or more keywords matched the following properties of Bogdanov, Alexei
keywords Magnetic Resonance Imaging


Molecular imaging probes and relevance of our research. Microscopy of tissue samples has traditionally been one of the mainstays of experimental biology. However, advances in our understanding of the biochemical basis of disease has made it desirable and even necessary to be able to image these changes as they happen in vivo, using techniques which are noninvasive. The goal of such techniques are several fold:1) to obtain, analyze, and monitor disease related changes in molecular physiology over time and with high spatial resolution, i.e., up to the level of individual cells,2) to simultaneously acquire highly accurate anatomical images (tissue mapping) while mapping the functional status of tissues and organs, and3) to allow fundamental research findings to be translated into clinically diagnostic imaging strategies.Towards this end, ‘molecular imaging’ utilizes signals from endogenous or exogenous (chemically engeneered) substrates to probe chemical reactions in living cells. Such ‘reporters’ or ‘sensors’ have been successfully used to track real time changes in molecular physiology using modern diagnostic imaging methods such as magnetic resonance imaging (MRI), positron emission tomography (PET), gamma scintigraphy, optical fluorescence and near-infrared imaging, to relate these changes to the initiation and progression of diseases such as atherosclerosis and cancer. In order to gain wide-spread use in a clinical setting, molecular probes must be biocompatible, easily administered, specific and effective at low dosages.Our research addresses the issue of increasing selectivity and sensitivity of imaging probes. We also apply this research in realistic models of diseases.

One or more keywords matched the following items that are connected to Bogdanov, Alexei
Item TypeName
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Academic Article Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model.
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Academic Article MR lymphography: study of a high-efficiency lymphotrophic agent.
Academic Article Detection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits.
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Academic Article A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies.
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Academic Article Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer.
Academic Article A paramagnetic contrast agent with myeloperoxidase-sensing properties.
Academic Article Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes.
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Academic Article Determinants of in vivo MR imaging of slow axonal transport.
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Academic Article Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging.
Academic Article MR imaging of slow axonal transport in vivo.
Academic Article Monocrystalline iron oxide nanocompounds (MION): physicochemical properties.
Academic Article MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model.
Academic Article Liposome-encapsulated superoxide dismutase mimetic: theranostic potential of an MR detectable and neuroprotective agent.
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Academic Article Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging.
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Academic Article High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease.
Academic Article 19F MRI of Polymer Nanogels Aided by Improved Segmental Mobility of Embedded Fluorine Moieties.
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Academic Article MR and fluorescence imaging of gadobutrol-induced optical clearing of red fluorescent protein signal in an in vivo cancer model.
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  • Magnetic Resonance Imaging