Header Logo

Search Result Details

Back to Search Results
This page shows the details of why an item matched the keywords from your search.
Search Results
Ryder, Sean
One or more keywords matched the following properties of Ryder, Sean
PropertyValue
overview

About the Ryder Lab:

We are interested in understanding the mechanisms that govern post-transcriptional regulation of gene expression during development and complex disease. Our research is focused primarily in three areas:

Ryder Lab Group Photo

  1. Post-transcriptional regulatory mechanisms involved in axis polarization and cell fate specification during Caenorhabditis elegans embryogenesis.

  2. Characterization of post-transcriptional regulatory mechanisms that guide oligodendrocyte differentiation and myelin formation in the vertebrate central nervous system.

  3. Identification of small molecule inhibitors of RNA-binding protein function using high throughput screening approaches.

We employ a combination of biochemical and molecular genetic methods, bioinformatics, chemical biology, biophysics, and structural analyses in our studies, with a focus on quantitative measurements. Our laboratory is located on the 9th floor of the Lazare Research Building in the Department of Biochemistry and Molecular Pharmacology at the University of Massachusetts Medical School. We enjoy a collaborative research environment that includes colleagues with related interests in worm biology, RNA biochemistry, developmental biology, or biophysics. Read more about our research here.

 
One or more keywords matched the following items that are connected to Ryder, Sean
Item TypeName
Academic Article RNA target specificity of the embryonic cell fate determinant POS-1.
Academic Article A quantitative RNA code for mRNA target selection by the germline fate determinant GLD-1.
Academic Article POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster.
Academic Article RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1.
Academic Article Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.
Academic Article RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3.
Academic Article FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans.
Academic Article A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels.
Concept Caenorhabditis elegans
Concept Caenorhabditis elegans Proteins
Academic Article RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1.
Academic Article POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Academic Article Efficient generation of transgenic reporter strains and analysis of expression patterns in Caenorhabditis elegans using library MosSCI.
Academic Article Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C.?elegans Zygote.
Academic Article Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.
Academic Article A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5.
Academic Article The endogenous mex-3 3?UTR is required for germline repression and contributes to optimal fecundity in C. elegans.
Academic Article The role of RNA-binding proteins in orchestrating germline development in Caenorhabditis elegans.
Academic Article A nematode model to evaluate microdeletion phenotype expression.
Academic Article Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity.
Search Criteria
  • Caenorhabditis