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About the Ryder Lab:

We are interested in understanding the mechanisms that govern post-transcriptional regulation of gene expression during development and complex disease. Our research is focused primarily in three areas:

Ryder Lab Group Photo

  1. Post-transcriptional regulatory mechanisms involved in axis polarization and cell fate specification during Caenorhabditis elegans embryogenesis.

  2. Characterization of post-transcriptional regulatory mechanisms that guide oligodendrocyte differentiation and myelin formation in the vertebrate central nervous system.

  3. Identification of small molecule inhibitors of RNA-binding protein function using high throughput screening approaches.

We employ a combination of biochemical and molecular genetic methods, bioinformatics, chemical biology, biophysics, and structural analyses in our studies, with a focus on quantitative measurements. Our laboratory is located on the 9th floor of the Lazare Research Building in the Department of Biochemistry and Molecular Pharmacology at the University of Massachusetts Medical School. We enjoy a collaborative research environment that includes colleagues with related interests in worm biology, RNA biochemistry, developmental biology, or biophysics. Read more about our research here.

 

Rotation Projects

Potential Rotation Projects

A variety of rotation projects are available to study RNP assembly and post-transcriptional regulation during development using quantitative biochemical and modern molecular methods.

Project 1: Characterization of the RNA-protein complexes that guide C. elegans early development. Several projects ranging in scope from biochemical characterization of RNA-binding protein complexes to genetic dissection of RNA binding protein function in development are currently available. Contact Sean for more details.

Project 2: Post-transcriptional regulation of oligodendrocyte differentiation. Projects are available to monitor changes in gene expression as a function of differentiation with a focus on changes in alternative splicing and mRNA stability. Contact Sean for more details.

One or more keywords matched the following items that are connected to Ryder, Sean
Item TypeName
Academic Article Post-transcriptional regulation of myelin formation.
Academic Article RNA target specificity of the embryonic cell fate determinant POS-1.
Academic Article The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p.
Academic Article Structure and function of nematode RNA-binding proteins.
Academic Article A quantitative RNA code for mRNA target selection by the germline fate determinant GLD-1.
Academic Article Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.
Academic Article Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.
Academic Article POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster.
Academic Article hnRNP A1 and secondary structure coordinate alternative splicing of Mag.
Academic Article Specificity of the STAR/GSG domain protein Qk1: implications for the regulation of myelination.
Academic Article Oskar gains weight.
Academic Article Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.
Academic Article Monitoring assembly of ribonucleoprotein complexes by isothermal titration calorimetry.
Academic Article RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3.
Academic Article Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes.
Academic Article Insights into the structural basis of RNA recognition by STAR domain proteins.
Academic Article FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans.
Academic Article A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels.
Concept Vesicular Transport Proteins
Concept Protein Binding
Concept DNA-Binding Proteins
Concept Carrier Proteins
Concept RNA-Binding Proteins
Academic Article RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1.
Academic Article Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite.
Academic Article A conserved three-nucleotide core motif defines Musashi RNA binding specificity.
Academic Article The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Academic Article POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Academic Article Efficient generation of transgenic reporter strains and analysis of expression patterns in Caenorhabditis elegans using library MosSCI.
Academic Article Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.
Academic Article Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes.
Academic Article Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.
Academic Article A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5.
Academic Article The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans.
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  • Carrier Proteins