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Search Results to Sean P Ryder PhD

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About the Ryder Lab:

We are interested in understanding the mechanisms that govern post-transcriptional regulation of gene expression during development and complex disease. Our research is focused primarily in three areas:

Ryder Lab Group Photo

  1. Post-transcriptional regulatory mechanisms involved in axis polarization and cell fate specification during Caenorhabditis elegans embryogenesis.

  2. Characterization of post-transcriptional regulatory mechanisms that guide oligodendrocyte differentiation and myelin formation in the vertebrate central nervous system.

  3. Identification of small molecule inhibitors of RNA-binding protein function using high throughput screening approaches.

We employ a combination of biochemical and molecular genetic methods, bioinformatics, chemical biology, biophysics, and structural analyses in our studies, with a focus on quantitative measurements. Our laboratory is located on the 9th floor of the Lazare Research Building in the Department of Biochemistry and Molecular Pharmacology at the University of Massachusetts Medical School. We enjoy a collaborative research environment that includes colleagues with related interests in worm biology, RNA biochemistry, developmental biology, or biophysics. Read more about our research here.

 


One or more keywords matched the following items that are connected to Ryder, Sean

Item TypeName
Academic Article Post-transcriptional regulation of myelin formation.
Academic Article Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.
Academic Article POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster.
Academic Article Metabolite sensing in eukaryotic mRNA biology.
Academic Article RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1.
Academic Article Specificity of the STAR/GSG domain protein Qk1: implications for the regulation of myelination.
Academic Article Oskar gains weight.
Academic Article Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.
Academic Article Regulation of maternal mRNAs in early development.
Academic Article RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3.
Academic Article FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans.
Academic Article A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels.
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Enzymologic
Academic Article Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite.
Academic Article POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Academic Article Altered activation of phospholipase D by lysophosphatidic acid and endothelin-1 in mouse embryo fibroblasts lacking phospholipase C-gamma1.

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  • Gene Expression Regulation