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Regulation of the innate immune response and its impact on disease

Evelyn Kurt-JonesResearch in my laboratory is focused on the role of receptor-mediated events in the pathogenesis of infectious and inflammatory processes. The discovery of the Toll-like receptors (TLRs) and their importance in the regulation of host responses to infection has focused attention on the complex interplay between pathogen genes and these host innate immune proteins in determining the outcome of infection. Our studies have demonstrated that pathogen-TLR interactions contribute to early control of infection (macrophage activation, type I interferon), recruitment of immune effector cells (chemokines) and the development of a sustained adaptive immune response (T and B cell activation and maturation). We have focused on host- and pathogen-derived proteins that regulate the magnitude and duration of the innate inflammatory response during viral infection and the impact of these factors on disease severity. Recently we have examined the role of innate immunity in the wound healing and the recruitment of stem cells involved in the regeneration of mucosal tissues. These studies point to the key role of innate immune receptor-triggered pathways in the initiation of healing and repair of damaged tissues following microbial or chemical insults as well as their significant role in disease pathogenesis.

Post Docs We are seeking a post-doctoral fellow to study toll/interleukin 1 receptors and their role in inflammatory disease pathogenesis using human cells and mouse models.

Candidates should have a Ph.D. or M.D. degree, or have completed degree requirements. Experience in immunology, molecular biology and/or biochemistry and publication of papers in the areas of cytokine biology, receptor biochemistry and/or cell signaling required.
Rotation Projects

Potential Rotation Projects

  1. Expression of Toll-like receptors: Patterns of TLR expression in normal cells. Control of TLR receptor expression by environmental factors and cytokines. TLR expression in diseased tissues.

  2. Role of TLRs in disease pathogenesis: Use of knockout and genetically defined animals to study the role of TLRs in the control of bacterial or viral diseases.

  3. Structure-function studies of TLR signaling: Assessing the signaling activity of wild type and mutant TLRs (altered by site-directed mutageneis) using transient transfection and luciferase reporter gene analysis.
One or more keywords matched the following items that are connected to Kurt-Jones, Evelyn
Item TypeName
Academic Article HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.
Academic Article Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils.
Academic Article The role of toll-like receptors in herpes simplex infection in neonates.
Academic Article Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo.
Academic Article Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury.
Academic Article Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis.
Academic Article The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.
Academic Article Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
Academic Article Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation.
Academic Article Cell activation by Toll-like receptors: role of LBP and CD14.
Academic Article Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
Academic Article The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.
Academic Article Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article Dicer's role as an antiviral: still an enigma.
Academic Article The role of platelets in mediating a response to human influenza infection.
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