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Regulation of the innate immune response and its impact on disease

Evelyn Kurt-JonesResearch in my laboratory is focused on the role of receptor-mediated events in the pathogenesis of infectious and inflammatory processes. The discovery of the Toll-like receptors (TLRs) and their importance in the regulation of host responses to infection has focused attention on the complex interplay between pathogen genes and these host innate immune proteins in determining the outcome of infection. Our studies have demonstrated that pathogen-TLR interactions contribute to early control of infection (macrophage activation, type I interferon), recruitment of immune effector cells (chemokines) and the development of a sustained adaptive immune response (T and B cell activation and maturation). We have focused on host- and pathogen-derived proteins that regulate the magnitude and duration of the innate inflammatory response during viral infection and the impact of these factors on disease severity. Recently we have examined the role of innate immunity in the wound healing and the recruitment of stem cells involved in the regeneration of mucosal tissues. These studies point to the key role of innate immune receptor-triggered pathways in the initiation of healing and repair of damaged tissues following microbial or chemical insults as well as their significant role in disease pathogenesis.

Rotation Projects

Potential Rotation Projects

  1. Expression of Toll-like receptors: Patterns of TLR expression in normal cells. Control of TLR receptor expression by environmental factors and cytokines. TLR expression in diseased tissues.


  2. Role of TLRs in disease pathogenesis: Use of knockout and genetically defined animals to study the role of TLRs in the control of bacterial or viral diseases.


  3. Structure-function studies of TLR signaling: Assessing the signaling activity of wild type and mutant TLRs (altered by site-directed mutageneis) using transient transfection and luciferase reporter gene analysis.
One or more keywords matched the following items that are connected to Kurt-Jones, Evelyn
Item TypeName
Academic Article Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus.
Academic Article Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils.
Academic Article Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
Academic Article Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
Academic Article Linking the "two-hit" response following injury to enhanced TLR4 reactivity.
Academic Article Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4.
Academic Article Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
Academic Article Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificity.
Academic Article Viruses and Toll-like receptors.
Academic Article The role of toll-like receptors in herpes simplex infection in neonates.
Academic Article MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.
Academic Article Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2.
Academic Article Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Academic Article Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo.
Academic Article Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
Academic Article Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury.
Academic Article Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA.
Academic Article Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis.
Academic Article Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Academic Article Toll-like receptor-mediated activation of neutrophils by influenza A virus.
Academic Article Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.
Academic Article The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.
Academic Article Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.
Academic Article Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice.
Academic Article Discovery of a novel TLR2 signaling inhibitor with anti-viral activity.
Academic Article Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice.
Academic Article Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.
Academic Article IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice.
Academic Article A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.
Academic Article Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
Academic Article Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice.
Academic Article Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
Academic Article Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
Academic Article Cell activation by Toll-like receptors: role of LBP and CD14.
Academic Article Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Academic Article Herpes simplex virus and toll-like receptors.
Academic Article Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
Academic Article CD14: chaperone or matchmaker?
Academic Article Toll like receptors and viruses.
Academic Article Tolls: you pay them on the way in and on the way out!
Academic Article Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
Academic Article Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion.
Academic Article Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
Academic Article UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
Academic Article Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells.
Academic Article Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2.
Academic Article Alcohol-induced IL-1? in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.
Concept Toll-Like Receptors
Concept Toll-Like Receptor 4
Concept Toll-Like Receptor 9
Concept Toll-Like Receptor 3
Concept Toll-Like Receptor 2
Concept Toll-Like Receptor 7
Concept Toll-Like Receptor 5
Concept Toll-Like Receptor 1
Concept Toll-Like Receptor 8
Academic Article Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.
Academic Article Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.
Academic Article Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
Academic Article Novel strategies for targeting innate immune responses to influenza.
Academic Article Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
Academic Article miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
Academic Article The role of platelets in mediating a response to human influenza infection.
Academic Article Alcohol-induced adipose tissue macrophage phenotypic switching is independent of myeloid Toll-like receptor 4 expression.
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  • Toll Like Receptors