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Rotation Projects
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Potential Rotation Projects - Expression of Toll-like receptors: Patterns of TLR expression in normal cells. Control of TLR receptor expression by environmental factors and cytokines. TLR expression in diseased tissues.
- Role of TLRs in disease pathogenesis: Use of knockout and genetically defined animals to study the role of TLRs in the control of bacterial or viral diseases.
- Structure-function studies of TLR signaling: Assessing the signaling activity of wild type and mutant TLRs (altered by site-directed mutageneis) using transient transfection and luciferase reporter gene analysis.
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