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Gounis, Matthew

One or more keywords matched the following properties of Gounis, Matthew

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overview	Matt Gounis, PhD, is a biomedical engineer and tenured Professor of the Department of Radiology, University of Massachusetts Medical School. He co-founded the New England Center for Stroke Research at UMASS in 2006 where the team works to bring new imaging and medical device technology from the bench to the clinic. For 25 years, Matt has performed research on the minimally invasive treatment of cerebrovascular disease with a focus on device technology, pre-clinical disease modeling, and image-guided surgery. Matt is the 2010 recipient of the Y.C. Fung Award from the ASME, the Founding President of the SB3C Foundation, formerly the Chair of the Bioengineering Division of the ASME and the AHA Clinical Bioengineering Committee, Fellow of ASME and currently serves as the Basic Science Associate Editor for the Journal of Neurointerventional Surgery and on the Editorial Board of the journals Stroke, and Neurosurgery. Matt has given over 150 invited lectures around the world, including delivering the distinguished Pierre Lasjuanias Memorial Lecture at the 15th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in Naples, Italy. Matt currently serves at the Chair of the UMMS IACUC, Vice Chair of Research for the Department of Radiology and as the Chair of the Departmental Personnel Action Committee. On-going research projects: 1. 5R44NS076272-03, NIH (PI: A Krtolica) 8/1/2017-7/31/2020 (NCE) Reducing brain injury after focal ischemia using a nitric oxide-neutral oxygen carrier. Role: Subcontract PI In this project, we test engineered a safe first-in-class oxygen carrier (OMX) that improves brain oxygenation after stroke to preserve the neuronal and glial cell network viability within the oxygen-deprived penumbra tissue, resulting in the amelioration of neurological function. 2. 5R01NS091552-04, NIH (MPIs: AA Bogdanov, MJ Gounis) 9/15/2015-7/31/2020 (NCE) Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging Role: MPI The ultimate goal of this proposal is to develop inroads to identification of aneurysms at risk of rupture and identify through the proposed experiments how specific and sensitive the imaging probes are in tracking active remodeling in aneurysm models. 3. 2R44NS100163-02, NIH (PI: GJ Ughi) 7/15/2018-4/30/2020 Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms Role: Subcontract Co-I The goal of this program is to provide a highly effective, high-resolution, imaging tool for the guidance of neuroendovascular procedures for brain aneurysm repair. 4. 2017104, BSF (PIs: N Korin, MJ Gounis) 10/1/2018-9/30/2022 Hemodynamic transport of drug carriers to cerebral aneurysms Role: Co-PI Our main goal is to elucidate the role of hemodynamics on particle dynamics at aneurysm sites and study the effect of particulate drug carrier properties on targeting aneurysms. 5. 2R44NS095573-03A1, NIH (PI: Merrill – FocalCool) 9/30/2019-8/31/2021 Rapid and effective localized neurovascular cooling using the Khione insulative catheter. Role: Subcontract PI Following a successful Phase 1 study that demonstrated proof-of-concept of rapid, deep focal cooling during temporary middle cerebral artery occlusion in a large animal model; this Phase 2 grant seeks to demonstrate the efficacy of this approach of peri-procedural focal hypothermia to improve functional outcomes in an acute stroke model. 6. Award #563749, Gilbert Family Fdn (PIs: MS Sena-Esteves) 12/1/2018-11/30/2021 Multipronged Approach to Development of NF1 Gene Therapeutics Neurofibromatosis Type I Role: Co-I The aims of this project are to develop (1) AAV vectors for NF1 delivery and expression restoration and (2) a zinc finger protein (ZFP) or antisense oligonucleotides (ASOs) to achieve dosage compensation in haploinsufficient (NF1+/-) cells. 7. Bits to Bytes, Massachusetts Life Sciences Center (PI: MJ Gounis) 7/1/2019-06/30/2022 Artificial intelligence in high-resolution neurovascular imaging for improving the treatment of stroke Role: PI The aim of the proposed research is the development of machine learning methodologies for an efficient analysis of HF-OCT data. The developments proposed in this grant hold great potential to revolutionize the current treatment and understanding of brain aneurysms.

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Value

overview

Matt Gounis, PhD, is a biomedical engineer and tenured Professor of the Department of Radiology, University of Massachusetts Medical School. He co-founded the New England Center for Stroke Research at UMASS in 2006 where the team works to bring new imaging and medical device technology from the bench to the clinic. For 25 years, Matt has performed research on the minimally invasive treatment of cerebrovascular disease with a focus on device technology, pre-clinical disease modeling, and image-guided surgery. Matt is the 2010 recipient of the Y.C. Fung Award from the ASME, the Founding President of the SB3C Foundation, formerly the Chair of the Bioengineering Division of the ASME and the AHA Clinical Bioengineering Committee, Fellow of ASME and currently serves as the Basic Science Associate Editor for the Journal of Neurointerventional Surgery and on the Editorial Board of the journals Stroke, and Neurosurgery. Matt has given over 150 invited lectures around the world, including delivering the distinguished Pierre Lasjuanias Memorial Lecture at the 15th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in Naples, Italy. Matt currently serves at the Chair of the UMMS IACUC, Vice Chair of Research for the Department of Radiology and as the Chair of the Departmental Personnel Action Committee.

On-going research projects:

1. 5R44NS076272-03, NIH (PI: A Krtolica) 8/1/2017-7/31/2020 (NCE)

Reducing brain injury after focal ischemia using a nitric oxide-neutral oxygen carrier.

Role: Subcontract PI

In this project, we test engineered a safe first-in-class oxygen carrier (OMX) that improves brain oxygenation after stroke to preserve the neuronal and glial cell network viability within the oxygen-deprived penumbra tissue, resulting in the amelioration of neurological function.

2. 5R01NS091552-04, NIH (MPIs: AA Bogdanov, MJ Gounis) 9/15/2015-7/31/2020 (NCE)

Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging

Role: MPI

The ultimate goal of this proposal is to develop inroads to identification of aneurysms at risk of rupture and identify through the proposed experiments how specific and sensitive the imaging probes are in tracking active remodeling in aneurysm models.

3. 2R44NS100163-02, NIH (PI: GJ Ughi) 7/15/2018-4/30/2020

Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms

Role: Subcontract Co-I

The goal of this program is to provide a highly effective, high-resolution, imaging tool for the guidance of neuroendovascular procedures for brain aneurysm repair.

4. 2017104, BSF (PIs: N Korin, MJ Gounis) 10/1/2018-9/30/2022

Hemodynamic transport of drug carriers to cerebral aneurysms

Role: Co-PI

Our main goal is to elucidate the role of hemodynamics on particle dynamics at aneurysm sites and study the effect of particulate drug carrier properties on targeting aneurysms.

5. 2R44NS095573-03A1, NIH (PI: Merrill – FocalCool) 9/30/2019-8/31/2021

Rapid and effective localized neurovascular cooling using the Khione insulative catheter.

Role: Subcontract PI

Following a successful Phase 1 study that demonstrated proof-of-concept of rapid, deep focal cooling during temporary middle cerebral artery occlusion in a large animal model; this Phase 2 grant seeks to demonstrate the efficacy of this approach of peri-procedural focal hypothermia to improve functional outcomes in an acute stroke model.

6. Award #563749, Gilbert Family Fdn (PIs: MS Sena-Esteves) 12/1/2018-11/30/2021

Multipronged Approach to Development of NF1 Gene Therapeutics Neurofibromatosis Type I

Role: Co-I

The aims of this project are to develop (1) AAV vectors for NF1 delivery and expression restoration and (2) a zinc finger protein (ZFP) or antisense oligonucleotides (ASOs) to achieve dosage compensation in haploinsufficient (NF1+/-) cells.

7. Bits to Bytes, Massachusetts Life Sciences Center (PI: MJ Gounis) 7/1/2019-06/30/2022

Artificial intelligence in high-resolution neurovascular imaging for improving the treatment of stroke

Role: PI

The aim of the proposed research is the development of machine learning methodologies for an efficient analysis of HF-OCT data. The developments proposed in this grant hold great potential to revolutionize the current treatment and understanding of brain aneurysms.

One or more keywords matched the following items that are connected to Gounis, Matthew

Item Type	Name
Academic Article	Functional angiography.
Academic Article	Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study.
Academic Article	Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain.
Academic Article	Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas.
Academic Article	Neurovascular modeling: small-batch manufacturing of silicone vascular replicas.
Academic Article	Robust initialization of 2D-3D image registration using the projection-slice theorem and phase correlation.
Academic Article	Registration of 2D x-ray images to 3D MRI by generating pseudo-CT data.
Concept	Molecular Imaging
Concept	Imaging, Three-Dimensional
Concept	Magnetic Resonance Imaging
Concept	Diagnostic Imaging
Concept	Diffusion Magnetic Resonance Imaging
Concept	Phantoms, Imaging
Academic Article	MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall.
Academic Article	Imaging Inflammation in Cerebrovascular Disease.
Academic Article	Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles.
Academic Article	ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience.
Academic Article	Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia.
Academic Article	Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications.
Academic Article	Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.
Academic Article	Use of self-expanding stents for better intracranial flow diverter wall apposition.
Academic Article	Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform.
Academic Article	Development of a high resolution MRI intracranial atherosclerosis imaging phantom.
Academic Article	Pipeline Embolization Device for Pericallosal Artery Aneurysms: A Retrospective Single Center Safety and Efficacy Study.
Academic Article	High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease.
Academic Article	A stereotaxic breed-averaged, symmetric T2w canine brain atlas including detailed morphological and volumetrical data sets.
Academic Article	Robotic Assisted MRI-Guided Interventional Interstitial MR-Guided Focused Ultrasound Ablation in a Swine Model.
Academic Article	A canine model of mechanical thrombectomy in stroke.
Academic Article	Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion.
Academic Article	A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna.
Academic Article	Volume and Infusion Rate Dynamics of Intraparenchymal Central Nervous System Infusion in a Large Animal Model.
Academic Article	In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.
Academic Article	Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology.
Academic Article	Up around the bend: progress and promise of intravascular imaging in neurointerventional surgery.
Academic Article	Novel Oxygen Carrier Slows Infarct Growth in Large Vessel Occlusion Dog Model Based on Magnetic Resonance Imaging Analysis.
Academic Article	Impact of histological clot composition on preprocedure imaging and mechanical thrombectomy.
Academic Article	Molecular Magnetic Resonance Imaging of Aneurysmal Inflammation Using a Redox Active Iron Complex.
Academic Article	Assessment of thrombectomy procedure difficulty by neurointerventionalists based on vessel geometry parameters from carotid artery 3D reconstructions.

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Imaging Three Dimensional