Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Gounis, Matthew
PropertyValue
overview

Matt Gounis, PhD, is a biomedical engineer and tenured Professor of the Department of Radiology, University of Massachusetts Medical School. He co-founded the New England Center for Stroke Research at UMASS in 2006 where the team works to bring new imaging and medical device technology from the bench to the clinic. For 25 years, Matt has performed research on the minimally invasive treatment of cerebrovascular disease with a focus on device technology, pre-clinical disease modeling, and image-guided surgery. Matt is the 2010 recipient of the Y.C. Fung Award from the ASME, the Founding President of the SB3C Foundation, formerly the Chair of the Bioengineering Division of the ASME and the AHA Clinical Bioengineering Committee, Fellow of ASME and currently serves as the Basic Science Associate Editor for the Journal of Neurointerventional Surgery and on the Editorial Board of the journals Stroke, and Neurosurgery. Matt has given over 150 invited lectures around the world, including delivering the distinguished Pierre Lasjuanias Memorial Lecture at the 15th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in Naples, Italy. Matt currently serves at the Chair of the UMMS IACUC, Vice Chair of Research for the Department of Radiology and as the Chair of the Departmental Personnel Action Committee. 

On-going research projects:

1. 5R44NS076272-03, NIH (PI: A Krtolica)                              8/1/2017-7/31/2020 (NCE) 

Reducing brain injury after focal ischemia using a nitric oxide-neutral oxygen carrier.

Role: Subcontract PI

In this project, we test engineered a safe first-in-class oxygen carrier (OMX) that improves brain oxygenation after stroke to preserve the neuronal and glial cell network viability within the oxygen-deprived penumbra tissue, resulting in the amelioration of neurological function.

2. 5R01NS091552-04, NIH (MPIs: AA Bogdanov, MJ Gounis)    9/15/2015-7/31/2020 (NCE)

Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging

Role: MPI

The ultimate goal of this proposal is to develop inroads to identification of aneurysms at risk of rupture and identify through the proposed experiments how specific and sensitive the imaging probes are in tracking active remodeling in aneurysm models.

3.    2R44NS100163-02, NIH (PI: GJ Ughi)                                                               7/15/2018-4/30/2020

Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms

Role: Subcontract Co-I

The goal of this program is to provide a highly effective, high-resolution, imaging tool for the guidance of neuroendovascular procedures for brain aneurysm repair.

4. 2017104, BSF (PIs: N Korin, MJ Gounis)   10/1/2018-9/30/2022

Hemodynamic transport of drug carriers to cerebral aneurysms

Role: Co-PI

Our main goal is to elucidate the role of hemodynamics on particle dynamics at aneurysm sites and study the effect of particulate drug carrier properties on targeting aneurysms.

5. 2R44NS095573-03A1, NIH (PI: Merrill – FocalCool)                                     9/30/2019-8/31/2021

Rapid and effective localized neurovascular cooling using the Khione insulative catheter.

Role: Subcontract PI

Following a successful Phase 1 study that demonstrated proof-of-concept of rapid, deep focal cooling during temporary middle cerebral artery occlusion in a large animal model; this Phase 2 grant seeks to demonstrate the efficacy of this approach of peri-procedural focal hypothermia to improve functional outcomes in an acute stroke model.

6. Award #563749, Gilbert Family Fdn (PIs: MS Sena-Esteves)                      12/1/2018-11/30/2021

Multipronged Approach to Development of NF1 Gene Therapeutics Neurofibromatosis Type I

Role: Co-I

The aims of this project are to develop (1) AAV vectors for NF1 delivery and expression restoration and (2) a zinc finger protein (ZFP) or antisense oligonucleotides (ASOs) to achieve dosage compensation in haploinsufficient (NF1+/-) cells.

7. Bits to Bytes, Massachusetts Life Sciences Center (PI: MJ Gounis)   7/1/2019-06/30/2022

Artificial intelligence in high-resolution neurovascular imaging for improving the treatment of stroke

Role: PI

The aim of the proposed research is the development of machine learning methodologies for an efficient analysis of HF-OCT data. The developments proposed in this grant hold great potential to revolutionize the current treatment and understanding of brain aneurysms.

One or more keywords matched the following items that are connected to Gounis, Matthew
Item TypeName
Academic Article Detachable coil for cerebral aneurysms: in vitro evaluation of magnetic field interactions, heating, and artifacts at 3T.
Academic Article Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study.
Academic Article Contrast-enhanced angiographic cone-beam CT of cerebrovascular stents: experimental optimization and clinical application.
Academic Article Simple measurement of aneurysm residual after treatment: the SMART scale for evaluation of intracranial aneurysms treated with flow diverters.
Academic Article The effect of intracranial stent implantation on the curvature of the cerebrovasculature.
Academic Article Angiographic quantification of contrast medium washout from cerebral aneurysms after stent placement.
Academic Article Reduction of coil mass artifacts in high-resolution flat detector conebeam CT of cerebral stent-assisted coiling.
Academic Article Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas.
Academic Article Complex-shaped platinum coils for brain aneurysms: higher packing density, improved biomechanical stability, and midterm angiographic outcome.
Academic Article The effect of vascular reconstruction device-assisted coiling on packing density, effective neck coverage, and angiographic outcome: an in vitro study.
Academic Article Stent-assisted reconstructive endovascular repair of cranial fusiform atherosclerotic and dissecting aneurysms: long-term clinical and angiographic follow-up.
Academic Article Cerecyte versus platinum coils in the treatment of intracranial aneurysms: packing attenuation and clinical and angiographic midterm results.
Academic Article Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms.
Academic Article Advances in interventional neuroradiology.
Academic Article The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study.
Academic Article Temporal evolution of susceptibility artifacts from coiled aneurysms on MR angiography: an in vivo canine study.
Academic Article Closed-cell stent for coil embolization of intracranial aneurysms: clinical and angiographic results.
Concept Intracranial Aneurysm
Academic Article Myeloperoxidase in human intracranial aneurysms: preliminary evidence.
Academic Article Advances in stroke: Advances in interventional radiology 2013.
Academic Article Revolution in aneurysm treatment: flow diversion to cure aneurysms: a paradigm shift.
Academic Article Aneurysm permeability following coil embolization: packing density and coil distribution.
Academic Article Surpass flow diverter in the treatment of intracranial aneurysms: a prospective multicenter study.
Academic Article MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall.
Academic Article Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection.
Academic Article Flow diverter stents for unruptured saccular anterior circulation perforating artery aneurysms: safety, efficacy, and short-term follow-up.
Academic Article A Finite Element Method to Predict Adverse Events in Intracranial Stenting Using Microstents: In Vitro Verification and Patient Specific Case Study.
Academic Article Safety, efficacy, and short-term follow-up of the use of Pipeline Embolization Device in small (<2.5 mm) cerebral vessels for aneurysm treatment: single institution experience.
Academic Article Onyx embolization in distal dissecting posterior inferior cerebellar artery aneurysms.
Academic Article Stent-assisted coil embolization of aneurysms with small parent vessels: safety and efficacy analysis.
Academic Article Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT.
Academic Article Endovascular reconstruction of unruptured intradural vertebral artery dissecting aneurysms with the Pipeline embolization device.
Academic Article In situ tissue engineering: endothelial growth patterns as a function of flow diverter design.
Academic Article Use of the Pipeline embolization device for recurrent and residual cerebral aneurysms: a safety and efficacy analysis with short-term follow-up.
Academic Article Use of self-expanding stents for better intracranial flow diverter wall apposition.
Academic Article Surpass Flow Diverter for Treatment of Posterior Circulation Aneurysms.
Academic Article Pipeline Embolization Device for Pericallosal Artery Aneurysms: A Retrospective Single Center Safety and Efficacy Study.
Academic Article The Importance of Wall Apposition in Flow Diverters.
Academic Article Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia.
Academic Article Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion.
Academic Article Acute thrombus formation on phosphorilcholine surface modified flow diverters.
Academic Article Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations.
Academic Article High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion.
Academic Article Impact of age on cerebral aneurysm occlusion after flow diversion.
Academic Article Introduction. Formation, growth, and rupture: the biology and physics of cerebral aneurysms.
Academic Article Introduction: History and Development of Flow Diverter Technology and Evolution.
Academic Article High-resolution image-guided WEB aneurysm embolization by high-frequency optical coherence tomography.
Academic Article Distal radial artery (Snuffbox) access for intracranial aneurysm treatment using the Woven EndoBridge (WEB) device.
Academic Article Anatomic Snuffbox (Distal Radial Artery) and Radial Artery Access for Treatment of Intracranial Aneurysms with FDA-Approved Flow Diverters.
Academic Article Optical Coherence Tomography for Neurovascular Disorders.
Academic Article Biophysical targeting of high-risk cerebral aneurysms.
Academic Article High-frequency optical coherence tomography predictors of aneurysm occlusion following flow diverter treatment in a preclinical model.
Academic Article Molecular Magnetic Resonance Imaging of Aneurysmal Inflammation Using a Redox Active Iron Complex.
Academic Article Braid stability after flow diverter treatment of intracranial aneurysms: a systematic review and meta-analysis.
Search Criteria
  • Intracranial Aneurysm