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Gounis, Matthew
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Matt Gounis, PhD, is a biomedical engineer and tenured Professor of the Department of Radiology, University of Massachusetts Medical School. He co-founded the New England Center for Stroke Research at UMASS in 2006 where the team works to bring new imaging and medical device technology from the bench to the clinic. For 25 years, Matt has performed research on the minimally invasive treatment of cerebrovascular disease with a focus on device technology, pre-clinical disease modeling, and image-guided surgery. Matt is the 2010 recipient of the Y.C. Fung Award from the ASME, the Founding President of the SB3C Foundation, formerly the Chair of the Bioengineering Division of the ASME and the AHA Clinical Bioengineering Committee, Fellow of ASME and currently serves as the Basic Science Associate Editor for the Journal of Neurointerventional Surgery and on the Editorial Board of the journals Stroke, and Neurosurgery. Matt has given over 150 invited lectures around the world, including delivering the distinguished Pierre Lasjuanias Memorial Lecture at the 15th Congress of the World Federation of Interventional and Therapeutic Neuroradiology in Naples, Italy. Matt currently serves at the Chair of the UMMS IACUC, Vice Chair of Research for the Department of Radiology and as the Chair of the Departmental Personnel Action Committee. 

On-going research projects:

1. 5R44NS076272-03, NIH (PI: A Krtolica)                              8/1/2017-7/31/2020 (NCE) 

Reducing brain injury after focal ischemia using a nitric oxide-neutral oxygen carrier.

Role: Subcontract PI

In this project, we test engineered a safe first-in-class oxygen carrier (OMX) that improves brain oxygenation after stroke to preserve the neuronal and glial cell network viability within the oxygen-deprived penumbra tissue, resulting in the amelioration of neurological function.

2. 5R01NS091552-04, NIH (MPIs: AA Bogdanov, MJ Gounis)    9/15/2015-7/31/2020 (NCE)

Unruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular Imaging

Role: MPI

The ultimate goal of this proposal is to develop inroads to identification of aneurysms at risk of rupture and identify through the proposed experiments how specific and sensitive the imaging probes are in tracking active remodeling in aneurysm models.

3.    2R44NS100163-02, NIH (PI: GJ Ughi)                                                               7/15/2018-4/30/2020

Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms

Role: Subcontract Co-I

The goal of this program is to provide a highly effective, high-resolution, imaging tool for the guidance of neuroendovascular procedures for brain aneurysm repair.

4. 2017104, BSF (PIs: N Korin, MJ Gounis)   10/1/2018-9/30/2022

Hemodynamic transport of drug carriers to cerebral aneurysms

Role: Co-PI

Our main goal is to elucidate the role of hemodynamics on particle dynamics at aneurysm sites and study the effect of particulate drug carrier properties on targeting aneurysms.

5. 2R44NS095573-03A1, NIH (PI: Merrill – FocalCool)                                     9/30/2019-8/31/2021

Rapid and effective localized neurovascular cooling using the Khione insulative catheter.

Role: Subcontract PI

Following a successful Phase 1 study that demonstrated proof-of-concept of rapid, deep focal cooling during temporary middle cerebral artery occlusion in a large animal model; this Phase 2 grant seeks to demonstrate the efficacy of this approach of peri-procedural focal hypothermia to improve functional outcomes in an acute stroke model.

6. Award #563749, Gilbert Family Fdn (PIs: MS Sena-Esteves)                      12/1/2018-11/30/2021

Multipronged Approach to Development of NF1 Gene Therapeutics Neurofibromatosis Type I

Role: Co-I

The aims of this project are to develop (1) AAV vectors for NF1 delivery and expression restoration and (2) a zinc finger protein (ZFP) or antisense oligonucleotides (ASOs) to achieve dosage compensation in haploinsufficient (NF1+/-) cells.

7. Bits to Bytes, Massachusetts Life Sciences Center (PI: MJ Gounis)   7/1/2019-06/30/2022

Artificial intelligence in high-resolution neurovascular imaging for improving the treatment of stroke

Role: PI

The aim of the proposed research is the development of machine learning methodologies for an efficient analysis of HF-OCT data. The developments proposed in this grant hold great potential to revolutionize the current treatment and understanding of brain aneurysms.
One or more keywords matched the following items that are connected to Gounis, Matthew
Item TypeName
Academic Article Update of the stroke therapy academic industry roundtable preclinical recommendations.
Academic Article Mechanical characterization of thromboemboli in acute ischemic stroke and laboratory embolus analogs.
Academic Article The Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease.
Academic Article Preclinical acute ischemic stroke modeling.
Academic Article Quantitative evaluation of C-arm CT cerebral blood volume in a canine model of ischemic stroke.
Academic Article Preclinical investigations for thrombectomy devices--does it translate to humans?
Academic Article Hemodynamics of carotid artery atherosclerotic occlusive disease.
Academic Article Stent-assisted reconstructive endovascular repair of cranial fusiform atherosclerotic and dissecting aneurysms: long-term clinical and angiographic follow-up.
Academic Article Advances in interventional neuroradiology.
Academic Article Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study.
Concept Stroke
Academic Article Myeloperoxidase in human intracranial aneurysms: preliminary evidence.
Academic Article Advances in stroke: Advances in interventional radiology 2013.
Academic Article Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics.
Academic Article Endovascular treatment of tandem vascular occlusions in acute ischemic stroke.
Academic Article Imaging Inflammation in Cerebrovascular Disease.
Academic Article Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion.
Academic Article ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience.
Academic Article Academic-industry Collaborations in Translational Stroke Research.
Academic Article Two-year single-center experience with the 'Baby Trevo' stent retriever for mechanical thrombectomy in acute ischemic stroke.
Academic Article An in vitro evaluation of distal emboli following Lazarus Cover-assisted stent retriever thrombectomy.
Academic Article Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.
Academic Article Emergent Endovascular Management of Long-Segment and Flow-Limiting Carotid Artery Dissections in Acute Ischemic Stroke Intervention with Multiple Tandem Stents.
Academic Article Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions.
Academic Article Histological Composition and the Origin of the Thrombus: A New Diagnostic Assay for Secondary Stroke Prevention?
Academic Article Intravascular Optical Coherence Tomography for Neurointerventional Surgery.
Academic Article Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization.
Academic Article Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations.
Academic Article Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT.
Academic Article A canine model of mechanical thrombectomy in stroke.
Academic Article Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source.
Academic Article Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept.
Academic Article Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion.
Academic Article Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations.
Academic Article Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment.
Academic Article Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots.
Academic Article Biomechanics and hemodynamics of stent-retrievers.
Academic Article Efficacy of beveled tip aspiration catheter in mechanical thrombectomy for acute ischemic stroke.
Academic Article Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology.
Academic Article Per pass analysis of thrombus composition retrieved by mechanical thrombectomy.
Academic Article Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy.
Academic Article A clinical perspective on endovascular stroke treatment biomechanics.
Academic Article Quantification of clot spatial heterogeneity and its impact on thrombectomy.
Academic Article Preclinical modeling of mechanical thrombectomy.
Academic Article Flow Diverter Reconstruction of Internal Carotid Artery (Loop) Dissections with or without Associated Pseudoaneurysms.
Academic Article Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?
Academic Article Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use.
Academic Article Novel Oxygen Carrier Slows Infarct Growth in Large Vessel Occlusion Dog Model Based on Magnetic Resonance Imaging Analysis.
Academic Article Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study.
Academic Article Super large-bore ingestion of clot (SLIC) leads to high first pass effect in thrombectomy for large vessel occlusion.
Academic Article Dawn of a New Era: Super Large-Bore Aspiration Catheters for Complete Clot Ingestion During Thrombectomy for Large-Vessel Occlusions.
Academic Article Development of a clot-adhesive coating to improve the performance of thrombectomy devices.
Academic Article Clot composition and recanalization outcomes in mechanical thrombectomy.
Academic Article Assessment of thrombectomy procedure difficulty by neurointerventionalists based on vessel geometry parameters from carotid artery 3D reconstructions.
Academic Article What is a?Challenging Clot? : A?DELPHI Consensus Statement from the CLOTS 7.0 Summit.
Academic Article ARISE I Consensus Review on the Management of Intracranial Aneurysms.
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  • Stroke