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Guertin, David

One or more keywords matched the following items that are connected to Guertin, David

Item Type	Name
Academic Article	Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Academic Article	The pharmacology of mTOR inhibition.
Academic Article	mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Academic Article	Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Academic Article	Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.
Academic Article	Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Academic Article	mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Academic Article	mTOR-dependent cell survival mechanisms.
Concept	Multiprotein Complexes
Academic Article	Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.
Academic Article	Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.

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Multiprotein Complexes