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One or more keywords matched the following properties of Ram, Sanjay
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The focus of our group is to elucidate how the complement system (an arm of innate immune defenses) interacts with Neisseria gonorrhoeae (the bacteria that cause gonorrhea) and N. meningitidis (the agent of bacterial meningitis).  This knowledge is now being used to develop novel immunotherapeutics and vaccines against multidrug-resistant gonorrhea.  Gonococci scavenge host complement inhibitors to escape killing by complement.  The first approach being investigated includes fusing the microbial binding region of complement inhibitors with the Fc region of antibody, which enhances complement-dependent lysis of bacteria.  A key aspect of gonococcal pathogenesis is its ability to use a sugar called sialic acid from the host to escape immune defenses.  In the second approach, we are investigating the use of analogs of sialic acid that are taken up by the bacteria, but unlike the ‘physiological’ form of sialic acid, fail to protect the bacteria against host defenses and results in faster clearance of bacteria in the murine model of gonorrhea. In collaboration with Dr. Peter Rice's group at UMass, our group is developing a monoclonal antibody and a vaccine that target a gonococcal glycan epitope. 


 

One or more keywords matched the following items that are connected to Ram, Sanjay
Item TypeName
Academic Article Factor H and neisserial pathogenesis.
Academic Article Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection.
Academic Article Phenotypic and genotypic analyses of Neisseria gonorrhoeae isolates that express frequently recovered PorB PIA variable region types suggest that certain P1a porin sequences confer a selective advantage for urogenital tract infection.
Academic Article Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum.
Academic Article Contribution of interactions between complement inhibitor C4b-binding protein and pathogens to their ability to establish infection with particular emphasis on Neisseria gonorrhoeae.
Academic Article Species-specificity of Neisseria gonorrhoeae infection: do human complement regulators contribute?
Academic Article Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection.
Concept Gonorrhea
Academic Article Antibody to reduction modifiable protein increases the bacterial burden and the duration of gonococcal infection in a mouse model.
Academic Article a-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tract.
Academic Article Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics.
Academic Article A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.
Academic Article Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics.
Academic Article Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development.
Academic Article A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity.
Academic Article Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae.
Academic Article Species-specific differences in regulation of macrophage inflammation by the C3a-C3a receptor axis.
Academic Article Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart.
Academic Article Targeting Lipooligosaccharide (LOS) for a Gonococcal Vaccine.
Academic Article Biology of the Gonococcus: Disease and Pathogenesis.
Academic Article Complement-Dependent Serum Bactericidal Assays for Neisseria gonorrhoeae.
Academic Article Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.
Academic Article C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections.
Academic Article Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine.
Academic Article Bypassing Phase Variation of Lipooligosaccharide (LOS): Using Heptose 1 Glycan Mutants To Establish Widespread Efficacy of Gonococcal Anti-LOS Monoclonal Antibody 2C7.
Academic Article Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states, and evasion mechanisms.
Academic Article Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae.
Academic Article Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins.
Academic Article Development of Complement Factor H-Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae.
Academic Article Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection.
Academic Article Efficacy of an Experimental Gonococcal Lipooligosaccharide Mimitope Vaccine Requires Terminal Complement.
Academic Article Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden.
Academic Article An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae.
Academic Article Gardnerella Vaginolysin Potentiates Glycan Molecular Mimicry by Neisseria gonorrhoeae.
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  • Gonorrhea