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MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.
MAP Kinase Kinase Kinase 2
Mitogen-Activated Protein Kinase Kinases
MAP Kinase Kinase 6
MAP Kinase Kinase 3
MAP Kinase Kinase Kinases
p38? MAPK is required for tooth morphogenesis and enamel secretion.
Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6.
MEKK2 mediates an alternative ?-catenin pathway that promotes bone formation.
Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.
TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-?B.
S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway.
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
TAK1 mediates BMP signaling in cartilage.
TAK1 is an essential regulator of BMP signalling in cartilage.
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
Mitogen Activated Protein Kinase Kinases