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TNF Receptor-Associated Factor 6
TNF Receptor-Associated Factor 2
Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6.
Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.
TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-?B.
Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal.
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
TNF Receptor Associated Factor 2