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Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.
CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing.
Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor.
Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses.
Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses.
CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms.
Signal transduction induced by immunostimulatory CpG DNA.
CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens.