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Highly immunostimulatory CpG-free oligodeoxynucleotides for activation of human leukocytes.
Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells.
CpG oligodeoxynucleotides stimulate IFN-gamma-inducible protein-10 production in human B cells.
CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species.
Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist.
CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha.
CpG DNA and LPS induce distinct patterns of activation in human monocytes.
Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses.
Heterogeneous expression and coordinate regulation of endogenous retroviral sequences in human peripheral blood mononuclear cells.
Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpesvirus-1 shedding.
Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides.
Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.
CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands.
Innate immune responses induced by classes of CpG oligodeoxynucleotides in ovine lymph node and blood mononuclear cells.
Oligonucleotide uptake in human hematopoietic cells is increased in leukemia and is related to cellular activation.