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Krieg, Arthur

One or more keywords matched the following items that are connected to Krieg, Arthur

Item Type	Name
Concept	Oligodeoxyribonucleotides, Antisense
Concept	Oligodeoxyribonucleotides
Academic Article	CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection.
Academic Article	C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level.
Academic Article	From A to Z on CpG.
Academic Article	CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study.
Academic Article	Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist.
Academic Article	Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals.
Academic Article	Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response.
Academic Article	Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells.
Academic Article	Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma.
Academic Article	Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.
Academic Article	Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration.
Academic Article	Antitumor mechanisms of oligodeoxynucleotides with CpG and polyG motifs in murine prostate cancer cells: decrease of NF-kappaB and AP-1 binding activities and induction of apoptosis.
Academic Article	Highly immunostimulatory CpG-free oligodeoxynucleotides for activation of human leukocytes.
Academic Article	CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.
Academic Article	Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step.
Academic Article	Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization.
Academic Article	Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells.
Academic Article	Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.
Academic Article	CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.
Academic Article	CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry.
Academic Article	CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL.
Academic Article	CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague.
Academic Article	CpG oligodeoxynucleotides stimulate IFN-gamma-inducible protein-10 production in human B cells.
Academic Article	The ability of CpG oligonucleotides to protect mice against Francisella tularensis live vaccine strain but not fully virulent F. tularensis subspecies holarctica is reflected in cell-based assays.
Academic Article	Paradoxical enhancement of CD8 T cell-dependent anti-tumor protection despite reduced CD8 T cell responses with addition of a TLR9 agonist to a tumor vaccine.
Academic Article	Antiinfective applications of toll-like receptor 9 agonists.
Academic Article	Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.
Academic Article	CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel.
Academic Article	Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist.
Academic Article	Cyclosporin A enhances IL-12 production by CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides.
Academic Article	CpG ODN enhances uptake of bacteria by mouse macrophages.
Academic Article	CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice.
Academic Article	CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha.
Academic Article	Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma.
Academic Article	CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner.
Academic Article	CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeast-expressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP1(19)) formulated in oil-based Montanides.
Academic Article	CpG still rocks! Update on an accidental drug.
Academic Article	Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques.
Academic Article	CpG motifs in bacterial DNA and their immune effects.
Academic Article	Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent manner.
Academic Article	Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy.
Academic Article	Identification of an oligodeoxynucleotide sequence motif that specifically inhibits phosphorylation by protein tyrosine kinases.
Academic Article	CpG-DNA protects against a lethal orthopoxvirus infection in a murine model.
Academic Article	Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis.
Academic Article	PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8? T cells induced by melanoma vaccines.
Academic Article	Clinical evaluation of safety and immunogenicity of PADRE-cytomegalovirus (CMV) and tetanus-CMV fusion peptide vaccines with or without PF03512676 adjuvant.
Academic Article	CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing.
Academic Article	Oral pretreatment of mice with CpG DNA reduces susceptibility to oral or intraperitoneal challenge with virulent Listeria monocytogenes.
Academic Article	CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma.
Academic Article	Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells.
Academic Article	CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma.
Academic Article	CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway.
Academic Article	Interruption of a transforming growth factor alpha autocrine loop in Caco-2 cells by antisense oligodeoxynucleotides.
Academic Article	The role of CpG motifs in innate immunity.
Academic Article	Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNalpha-producing cells and TLR9 mRNA expression.
Academic Article	CpG DNA: trigger of sepsis, mediator of protection, or both?
Academic Article	Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides.
Academic Article	Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor.
Academic Article	CpG oligonucleotides enhance the tumor antigen-specific immune response of an anti-idiotype antibody-based vaccine strategy in CEA transgenic mice.
Academic Article	CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming.
Academic Article	CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults.
Academic Article	Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses.
Academic Article	Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms.
Academic Article	CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells.
Academic Article	The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques.
Academic Article	Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.
Academic Article	Antibody repertoire development in fetal and neonatal piglets. IX. Three pathogen-associated molecular patterns act synergistically to allow germfree piglets to respond to type 2 thymus-independent and thymus-dependent antigens.
Academic Article	A novel class of immune-stimulatory CpG oligodeoxynucleotides unifies high potency in type I interferon induction with preferred structural properties.
Academic Article	Mechanism and function of a newly identified CpG DNA motif in human primary B cells.
Academic Article	Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo.
Academic Article	A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.
Academic Article	Inhibition of T4 polynucleotide kinase activity by phosphorothioate and chimeric oligodeoxynucleotides.
Academic Article	CpG oligodeoxynucleotide and Montanide ISA 51 adjuvant combination enhanced the protective efficacy of a subunit malaria vaccine.
Academic Article	Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides.
Academic Article	APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells.
Academic Article	Enhanced dendritic cell maturation by TNF-alpha or cytidine-phosphate-guanosine DNA drives T cell activation in vitro and therapeutic anti-tumor immune responses in vivo.
Academic Article	CpG DNA is an effective oral adjuvant to protein antigens in mice.
Academic Article	CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms.
Academic Article	P-chirality-dependent immune activation by phosphorothioate CpG oligodeoxynucleotides.
Academic Article	Therapeutic potential of Toll-like receptor 9 activation.
Academic Article	Adjuvant effects of CpG oligodeoxynucleotides on responses against T-independent type 2 antigens.
Academic Article	Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells.
Academic Article	Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer.
Academic Article	Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.
Academic Article	Paclitaxel reduces regulatory T cell numbers and inhibitory function and enhances the anti-tumor effects of the TLR9 agonist PF-3512676 in the mouse.
Academic Article	Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides.
Academic Article	Impact of modifications of heterocyclic bases in CpG dinucleotides on their immune-modulatory activity.
Academic Article	CpG DNA induces cyclooxygenase-2 expression and prostaglandin production.
Academic Article	Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy.
Academic Article	Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients.
Academic Article	CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans.
Academic Article	Positive T cell co-stimulation by TLR7/8 ligands is dependent on the cellular environment.
Academic Article	Subcutaneous, but not intratracheal administration of the TLR9 agonist, CpG DNA transiently reduces parainfluenza-3 virus shedding in newborn lambs.
Academic Article	CpG motifs in bacterial DNA trigger direct B-cell activation.
Academic Article	Signal transduction induced by immunostimulatory CpG DNA.
Academic Article	CpG oligonucleotides as immune adjuvants.
Academic Article	Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpesvirus-1 shedding.
Academic Article	Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers.
Academic Article	Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.
Academic Article	A possible cause of joint destruction in septic arthritis.
Academic Article	A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity.
Academic Article	Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotides.
Academic Article	Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.
Academic Article	Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice.
Academic Article	CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens.
Academic Article	Modulation of CpG oligodeoxynucleotide-mediated immune stimulation by locked nucleic acid (LNA).
Academic Article	Enhancing vaccines with immune stimulatory CpG DNA.
Academic Article	New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site.
Academic Article	Surgical excision combined with autologous whole tumor cell vaccination is an effective therapy for murine neuroblastoma.
Academic Article	Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer.
Academic Article	Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients.
Academic Article	From bugs to drugs: therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA.
Academic Article	Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.
Academic Article	Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma.
Academic Article	Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses.
Academic Article	Uptake of oligodeoxyribonucleotides by lymphoid cells is heterogeneous and inducible.
Academic Article	Immunostimulatory CpG oligodeoxynucleotide confers protection in a murine model of infection with Burkholderia pseudomallei.
Academic Article	Type I interferon is the primary regulator of inducible Ly-6C expression on T cells.
Academic Article	CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation.
Academic Article	CpG oligodeoxynucleotide enhances tumor response to radiation.
Academic Article	Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Academic Article	CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.
Academic Article	Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides.
Academic Article	Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells.
Academic Article	CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved.
Academic Article	Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists.
Academic Article	CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge.
Academic Article	Reduction of antigen expression from DNA vaccines by coadministered oligodeoxynucleotides.
Academic Article	Lactoferrin binds CpG-containing oligonucleotides and inhibits their immunostimulatory effects on human B cells.
Academic Article	Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy.
Academic Article	IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides.
Academic Article	Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine.
Academic Article	Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA.
Academic Article	Innate immune responses induced by classes of CpG oligodeoxynucleotides in ovine lymph node and blood mononuclear cells.
Academic Article	Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs.
Academic Article	Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta.
Academic Article	Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells.
Academic Article	Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation.
Academic Article	High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists.
Academic Article	Systemic innate immune responses following intrapulmonary delivery of CpG oligodeoxynucleotides in sheep.
Academic Article	Phosphorothioate oligodeoxynucleotides: antisense or anti-protein?
Academic Article	Enhanced antibody responses elicited by a CpG adjuvant do not improve the protective effect of an aldrithiol-2-inactivated simian immunodeficiency virus therapeutic AIDS vaccine.
Academic Article	Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.
Academic Article	CpG are efficient adjuvants for specific CTL induction against tumor antigen-derived peptide.
Academic Article	Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA.
Academic Article	Monocytes are required for optimum in vitro stimulation of bovine peripheral blood mononuclear cells by non-methylated CpG motifs.
Academic Article	Protection of Mice from Lethal Vaccinia Virus Infection by Vaccinia Virus Protein Subunits with a CpG Adjuvant.
Academic Article	Antibody Opsonization of a TLR9 Agonist-Containing Virus-like Particle Enhances In Situ Immunization.

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Oligodeoxyribonucleotides