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Medicinal chemistry and therapeutic potential of CpG DNA.
Secondary structures in CpG oligonucleotides affect immunostimulatory activity.
Chemistry of CpG DNA.
Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.
Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA.
Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells.
Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties.
Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice.
Impact of site-specific nucleobase deletions on the arthritogenicity of DNA.
Impact of secondary structure of toll-like receptor 9 agonists on interferon alpha induction.
Novel oligodeoxynucleotide agonists of TLR9 containing N3-Me-dC or N1-Me-dG modifications.
Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs.
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists.
Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9.
Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences.
Immunostimulatory properties of phosphorothioate CpG DNA containing both 3'-5'- and 2'-5'-internucleotide linkages.
Modulation of Toll-like Receptor 9 Responses through Synthetic Immunostimulatory Motifs of DNA.