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Agrawal, Sudhir
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Over three decades, three drug-discovery platforms based on RNA Therapeutics have been introduced in my laboratory. These include Antisense technology, Toll-Like Receptor Agonism, and Toll-Like Receptor Antagonism. Drug candidates from these technologies have been created and have advanced to clinical proof of concept trials in patients. Several drugs have been approved based on ASO chemistries and mechanisms developed in our labs. At a recent conference of the Oligonucleotide Therapeutic Society meeting, I reviewed the work in an award lecture.

https://www.youtube.com/watch?v=3fIXkkPiWp4

Publications available on Google Scholar
One or more keywords matched the following items that are connected to Agrawal, Sudhir
Item TypeName
Academic Article A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif.
Concept Toll-Like Receptor 9
Concept Toll-Like Receptor 3
Concept Toll-Like Receptor 7
Concept Toll-Like Receptor 8
Academic Article RAGE Enhances TLR Responses through Binding and Internalization of RNA.
Academic Article Role of Toll-like receptors in the pathogenesis of dystrophin-deficient skeletal and heart muscle.
Academic Article A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice.
Academic Article A TLR9 agonist enhances therapeutic effects of telomerase genetic vaccine.
Academic Article TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts.
Academic Article Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9.
Academic Article TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome.
Academic Article A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis.
Academic Article Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice.
Academic Article Coadministration of telomerase genetic vaccine and a novel TLR9 agonist in nonhuman primates.
Academic Article Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8.
Academic Article Impact of secondary structure of toll-like receptor 9 agonists on interferon alpha induction.
Academic Article Novel oligodeoxynucleotide agonists of TLR9 containing N3-Me-dC or N1-Me-dG modifications.
Academic Article Chemotherapy and chemosensitization of non-small cell lung cancer with a novel immunomodulatory oligonucleotide targeting Toll-like receptor 9.
Academic Article Toll-like receptor 7 selective synthetic oligoribonucleotide agonists: synthesis and structure-activity relationship studies.
Academic Article Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs.
Academic Article Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists.
Academic Article Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice.
Academic Article Towards optimal design of second-generation immunomodulatory oligonucleotides.
Academic Article Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8.
Academic Article Peptide conjugation at the 5'-end of oligodeoxynucleotides abrogates toll-like receptor 9-mediated immune stimulatory activity.
Academic Article Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists.
Academic Article Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9.
Academic Article Modulation of Toll-like Receptor 9 Responses through Synthetic Immunostimulatory Motifs of DNA.
Academic Article Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.
Academic Article Treatment of mammary carcinomas in HER-2 transgenic mice through combination of genetic vaccine and an agonist of Toll-like receptor 9.
Academic Article Synthetic oligoribonucleotides containing arabinonucleotides act as agonists of TLR7 and 8.
Academic Article A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action.
Academic Article Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8.
Academic Article Synthesis and immunological activities of novel agonists of toll-like receptor 9.
Academic Article An in situ autologous tumor vaccination with combined radiation therapy and TLR9 agonist therapy.
Academic Article Design of synthetic oligoribonucleotide-based agonists of Toll-like receptor 3 and their immune response profiles in vitro and in vivo.
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  • Toll Like Receptor 9