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Wang, Dan
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Our research centers around gene therapy using adeno-associated virus (AAV) vectors. We carry out translational gene therapy studies targeting several neurological and metabolic diseases. In addition to targeting specific diseases, we develop therapeutic platforms based on molecular approaches such as genome editing and RNA-based methods. We also develop platform technologies to facilitate AAV-based gene therapy, such as animal modeling and AAV vector production.

In 2020, the lab starts accepting graduate students, postdoctoral researchers, and research associates. Send in your application and get in touch today!
One or more keywords matched the following items that are connected to Wang, Dan
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Concept Dependovirus
Academic Article The potential of adeno-associated viral vectors for gene delivery to muscle tissue.
Academic Article Adeno-associated Virus Serotype Vectors Efficiently Transduce Normal Prostate Tissue and Prostate Cancer Cells.
Academic Article Short DNA Hairpins Compromise Recombinant Adeno-Associated Virus Genome Homogeneity.
Academic Article Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice.
Academic Article In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency.
Academic Article Slow Infusion of Recombinant Adeno-Associated Viruses into the Mouse Cerebrospinal Fluid Space.
Academic Article Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses.
Academic Article Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS.
Academic Article A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord.
Academic Article AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy.
Academic Article AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer.
Academic Article Intrathecal Adeno-Associated Viral Vector-Mediated Gene Delivery for Adrenomyeloneuropathy.
Academic Article Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer.
Academic Article Adeno-associated virus vector as a platform for gene therapy delivery.
Academic Article Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.
Academic Article Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis.
Academic Article Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno-Associated Virus.
Academic Article CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors.
Academic Article AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies.
Academic Article Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.
Academic Article AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice.
Academic Article Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.
Academic Article AAV5 Delivery of CRISPR/Cas9 Mediates Genome Editing in the Lungs of Young Rhesus Monkeys.
Academic Article Developing AAV-delivered nonsense suppressor tRNAs for neurological disorders.
Academic Article Systemic gene therapy corrects the neurological phenotype in a mouse model of NGLY1 deficiency.
Academic Article A comprehensive atlas of AAV tropism in the mouse.
Academic Article BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease.
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