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RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates.
Deaminase activity on single-stranded DNA (ssDNA) occurs in vitro when APOBEC3G cytidine deaminase forms homotetramers and higher-order complexes.
Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity.
Structural and functional assessment of APOBEC3G macromolecular complexes.
APOBEC 3G Deaminase