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Patel, Shyam
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Dr. Patel attended Rutgers – New Jersey Medical School and Rutgers - Graduate School of Biomedical Sciences from 2006-13, where he completed the physician-scientist training program (PSTP). He trained in the disciplines of stem cell biology and cancer biology. His thesis research focused on breast cancer dormancy in the bone marrow. He then completed Internal Medicine residency at Stanford University (2013-16) and Hematology/Oncology fellowship at Stanford University (2016-19), during which time he studied the leukemic stem cell niche in acute myeloid leukemia (AML). He is board-certified in Internal Medicine (2016), Hematology (2019), and Medical Oncology (2019).

He is Co-Director of the Blood, Immunity, and Infection course at UMass Chan Medical School.

His current research involves understanding the disease biology and clonal dynamics of TP53-mutant MDS and AML, as well as the genomics of clonal hematopoiesis (Patel SA et al., Br J Haematol 2024).

The Darkest Side of AML: The TP53 Mutation (umassmed.edu)

Oncology Times (lww.com)

Unpacking CHIP: Recent Updates, Remaining Questions | Blood Cancers Today

Dr Patel on the Impact of Donor-Engrafted Clonal Hematopoiesis on Outcomes With Auto-/Allo-HSCT (onclive.com)

Effects of donor-engrafted clonal hematopoiesis in stem cell transplantation - presented by Shyam Patel

 
One or more keywords matched the following items that are connected to Patel, Shyam
Item TypeName
Concept Tumor Suppressor Protein p53
Concept Hematologic Neoplasms
Concept Biomarkers, Tumor
Concept Colorectal Neoplasms, Hereditary Nonpolyposis
Concept Neoplasms, Second Primary
Concept Stomach Neoplasms
Concept Skull Neoplasms
Concept Lymphocytes, Tumor-Infiltrating
Concept Neoplasm Recurrence, Local
Concept Splenic Neoplasms
Concept Neoplasm Invasiveness
Concept Neoplasm Proteins
Concept Neoplasm Staging
Concept Tumor Escape
Concept Drug Resistance, Neoplasm
Concept Breast Neoplasms
Concept Neoplasms
Concept Neoplasm, Residual
Concept Cell Line, Tumor
Academic Article Stem Cell Transplantation for Hematological Malignancies: Prospects for Personalized Medicine and Co-therapy with Mesenchymal Stem Cells.
Academic Article Myelodysplastic Syndrome and Acute Myeloid Leukemia Risk Associated With Solid Tumor Chemotherapy.
Academic Article The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow.
Academic Article Challenges in the development of future treatments for breast cancer stem cells.
Academic Article Immunological properties of mesenchymal stem cells and clinical implications.
Academic Article Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells.
Academic Article Multi- and inter-disciplinary science in personalized delivery of stem cells for tissue repair.
Academic Article Primary extranodal marginal zone lymphoma involving the skull.
Academic Article Cancer immunotherapy: accomplishments to date and future promise.
Academic Article Investigating breast cancer cell behavior using tissue engineering scaffolds.
Academic Article Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta.
Academic Article Metastatic breast cancer cells in the bone marrow microenvironment: novel insights into oncoprotection.
Academic Article Harnessing antitumor immunity: Employment of tumor recall antigens to optimize the inflammatory response to cancer.
Academic Article Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy.
Academic Article Can breast cancer stem cells evade the immune system?
Academic Article An indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells.
Academic Article The inferior vena cava (IVC) syndrome as the initial manifestation of newly diagnosed gastric adenocarcinoma: a case report.
Academic Article A reporter assay to detect transfer and targeting of miRNAs in stem cell-breast cancer co-cultures.
Academic Article Inflammatory mediators: Parallels between cancer biology and stem cell therapy.
Academic Article AMD3100-mediated production of interleukin-1 from mesenchymal stem cells is key to chemosensitivity of breast cancer cells.
Academic Article Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy.
Academic Article microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis.
Academic Article Tumor Molecular Testing Guides Anti-PD-1 Therapy and Provides Evidence for Pathogenicity of Mismatch Repair Variants.
Academic Article Breast cancer biology: the multifaceted roles of mesenchymal stem cells.
Academic Article Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells.
Academic Article Treg/Th17 polarization by distinct subsets of breast cancer cells is dictated by the interaction with mesenchymal stem cells.
Academic Article The RNA-binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth.
Award or Honor Receipt Nat’l Comprehensive Cancer Network (NCCN) Oncology Fellows Educational Grant
Academic Article Altered mental status and hypercalcemia with a splenic mass.
Academic Article Mesenchymal Stem Cell-Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region.
Academic Article Targeted and cytotoxic therapies as maintenance treatment for non-transplant eligible patients with acute myeloid leukemia.
Academic Article Niche-directed therapy in acute myeloid leukemia: optimization of stem cell competition for niche occupancy.
Academic Article NF?B Targeting in Bone Marrow Mesenchymal Stem Cell-Mediated Support of Age-Linked Hematological Malignancies.
Academic Article Clinico-genomic profiling and clonal dynamic modeling of TP53-aberrant myelodysplastic syndrome and acute myeloid leukemia.
Academic Article Myocarditis, kidney injury, and hypereosinophilia: FIP1L1-PDGFRA-positive myeloid/lymphoid neoplasm with eosinophilia.
Academic Article The Novel Therapeutic Landscape for Relapsed/Refractory Diffuse Large B Cell Lymphoma.
Concept Tumor Microenvironment
Academic Article Functional genomic approaches in acute myeloid leukemia: Insights into disease models and the therapeutic potential of reprogramming.
Academic Article TP53-mutant myelodysplastic syndrome and acute myeloid leukemia: the black hole of hematology.
Grant Clinical Translation of an Innovative Leukemia Stem Cell Assay for Detection, Prognostication, and Precision Management of Blood Cancer
Academic Article The emerging therapeutic landscape of relapsed/refractory multiple myeloma.
Academic Article Telehealth through the pandemic at a safety net hospital: observations and next steps for cancer care delivery.
Academic Article Challenges and solutions to superior chimeric antigen receptor-T design and deployment for B-cell lymphomas.
Academic Article Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells.
Academic Article Translational insights into the genetics and immunobiology of relapsed/refractory follicular lymphoma.
Academic Article Managing the unmanageable: evidence-driven approaches to real-world patient prototypes of TP53-mutant myelodysplastic neoplasms and acute myeloid leukemia.
Academic Article Second Primary Cancer After Chimeric Antigen Receptor-T-Cell Therapy: A Review.
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  • Neoplasms