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One or more keywords matched the following properties of Lin, Honghuang

I am a bioinformatician/biostatistician with training in mathematics, machine learning, genetics, and digital medicine. Our lab is mainly focused on the development and application of computational tools to study complex diseases. 

  1. Identification of genetic causes of complex diseases. We have been involved in multiple large-scale genetic consortiums, such as the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Trans-Omics for Precision Medicine (TOPMed) program, and Alzheimer's Disease Sequencing Project (ADSP). These studies have identified hundreds of genetic loci associated with atrial fibrillation, heart failure, hypertension, and Alzheimer’s disease.
  2. Integration of multi-omics data to understand disease molecular mechanisms. Complex diseases are usually caused by the interplay of genetic and environmental factors. We have identified numerous molecular signatures from gene expression, protein expression, and DNA methylation that are related to aging and cardiovascular disease. We are also developing computational methods to integrate different molecular signatures and build gene interaction networks to study potential disease regulation networks.
  3. Development of machine learning models for early disease diagnosis. We have built multiple machine learning models to predict dementia risk from midlife risk factors and neuropsychological tests. In combination with neuroimaging and blood-based measures, we are also developing multimodal machine learning methods to identify new biomarkers that are predictive of future cognitive impairment.
  4. Exploration of digital and wearable devices for health monitoring. We have deployed thousands of wearable devices and mobile apps to monitor cardiovascular health and cognitive health. We are integrating active engagement with passive engagement technologies from the habitual environment to make sustained monitoring feasible. Novel analytic strategies are also being developed to analyze big unstructured data to identify potential digital biomarkers that are predictive of future health outcomes.
One or more keywords matched the following items that are connected to Lin, Honghuang
Item TypeName
Academic Article Atrial fibrillation: current knowledge and future directions in epidemiology and genomics.
Concept Atrial Fibrillation
Academic Article Gene expression and genetic variation in human atria.
Academic Article Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study.
Academic Article Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study.
Academic Article Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese.
Academic Article Whole blood gene expression and atrial fibrillation: the Framingham Heart Study.
Academic Article Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).
Academic Article Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).
Academic Article Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study.
Academic Article Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation.
Academic Article Multi-ethnic genome-wide association study for atrial fibrillation.
Academic Article Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study.
Academic Article Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study.
Academic Article Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential.
Academic Article P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study.
Academic Article Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation.
Academic Article Novel Risk Modeling Approach of Atrial Fibrillation With Restricted Mean Survival Times: Application in the Framingham Heart Study Community-Based Cohort.
Academic Article Protein Biomarkers and Risk of Atrial Fibrillation: The FHS.
Academic Article Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Academic Article Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
Academic Article Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization.
Academic Article Gene-gene Interaction Analyses for Atrial Fibrillation.
Academic Article Gain-of-function mutations in GATA6 lead to atrial fibrillation.
Academic Article Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
Academic Article Epigenetic Age and the Risk of Incident Atrial Fibrillation.
Academic Article New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation.
Academic Article Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation.
Academic Article Integrative Omics Approach to Identifying Genes Associated With Atrial Fibrillation.
Academic Article Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study.
Academic Article Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
Academic Article Whole Exome Sequencing in Atrial Fibrillation.
Academic Article Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
Academic Article The association between social network index, atrial fibrillation, and mortality in the Framingham Heart Study.
Academic Article Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study.
Academic Article Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.
Academic Article Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference.
Academic Article Psychosocial measures in relation to smartwatch alerts for atrial fibrillation detection.
Academic Article The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study.
Academic Article Step Count, Self-reported Physical Activity, and Predicted 5-Year Risk of Atrial Fibrillation: Cross-sectional Analysis.
Academic Article The bidirectional association between atrial fibrillation and myocardial infarction.
Academic Article Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings: The Framingham Heart Study.
Search Criteria
  • Atrial Fibrillation