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One or more keywords matched the following properties of Lin, Honghuang
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I am a bioinformatician/biostatistician with training in mathematics, machine learning, genetics, and digital medicine. Our lab is mainly focused on the development and application of computational tools to study complex diseases. 

  1. Identification of genetic causes of complex diseases. We have been involved in multiple large-scale genetic consortiums, such as the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Trans-Omics for Precision Medicine (TOPMed) program, and Alzheimer's Disease Sequencing Project (ADSP). These studies have identified hundreds of genetic loci associated with atrial fibrillation, heart failure, hypertension, and Alzheimer’s disease.
  2. Integration of multi-omics data to understand disease molecular mechanisms. Complex diseases are usually caused by the interplay of genetic and environmental factors. We have identified numerous molecular signatures from gene expression, protein expression, and DNA methylation that are related to aging and cardiovascular disease. We are also developing computational methods to integrate different molecular signatures and build gene interaction networks to study potential disease regulation networks.
  3. Development of machine learning models for early disease diagnosis. We have built multiple machine learning models to predict dementia risk from midlife risk factors and neuropsychological tests. In combination with neuroimaging and blood-based measures, we are also developing multimodal machine learning methods to identify new biomarkers that are predictive of future cognitive impairment.
  4. Exploration of digital and wearable devices for health monitoring. We have deployed thousands of wearable devices and mobile apps to monitor cardiovascular health and cognitive health. We are integrating active engagement with passive engagement technologies from the habitual environment to make sustained monitoring feasible. Novel analytic strategies are also being developed to analyze big unstructured data to identify potential digital biomarkers that are predictive of future health outcomes.
One or more keywords matched the following items that are connected to Lin, Honghuang
Item TypeName
Concept Heart
Concept Heart Septal Defects, Atrial
Concept Heart Failure
Concept Heart Defects, Congenital
Concept Heart Conduction System
Concept Heart Rate
Concept Heart Atria
Concept Heart Ventricles
Concept Heart Valve Diseases
Concept Heart Diseases
Concept Heart Septal Defects, Ventricular
Academic Article Gene expression and genetic variation in human atria.
Academic Article Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study.
Academic Article Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study.
Academic Article Whole blood gene expression and atrial fibrillation: the Framingham Heart Study.
Academic Article Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).
Academic Article Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study.
Academic Article Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).
Academic Article Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study.
Academic Article Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study.
Academic Article Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study.
Academic Article Comparison of On-Site Versus Remote Mobile Device Support in the Framingham Heart Study Using the Health eHeart Study for Digital Follow-up: Randomized Pilot Study Set Within an Observational Study Design.
Academic Article Epigenome-Wide Association Study of Soluble Tumor Necrosis Factor Receptor 2 Levels in the Framingham Heart Study.
Academic Article Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor a.
Academic Article Association of Habitual Physical Activity With Home Blood Pressure in the Electronic Framingham Heart Study (eFHS): Cross-sectional Study.
Academic Article P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study.
Academic Article Genetic Reduction in Left Ventricular Protein Kinase C-a and Adverse Ventricular Remodeling in Human Subjects.
Academic Article The genomics of heart failure: design and rationale of the HERMES consortium.
Academic Article Shared Genetic and Environmental Architecture of Cardiac Phenotypes Assessed via Echocardiography: The Framingham Heart Study.
Academic Article Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits.
Academic Article Novel Risk Modeling Approach of Atrial Fibrillation With Restricted Mean Survival Times: Application in the Framingham Heart Study Community-Based Cohort.
Academic Article Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Academic Article ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.
Academic Article Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort.
Academic Article Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.
Academic Article Gain-of-function mutations in GATA6 lead to atrial fibrillation.
Academic Article Genome-wide association analysis of plasma B-type natriuretic peptide in blacks: the Jackson Heart Study.
Academic Article Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Academic Article Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study.
Academic Article Association Between the Digital Clock Drawing Test and Neuropsychological Test Performance: Large Community-Based Prospective Cohort (Framingham Heart Study).
Academic Article Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross-Sectional Analysis of the Plasma Proteome in the Framingham Heart Study.
Academic Article Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation.
Academic Article Exploring the Hierarchical Influence of Cognitive Functions for Alzheimer Disease: The Framingham Heart Study.
Academic Article Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study.
Academic Article Healthy diet is associated with gene expression in blood: the Framingham Heart Study.
Academic Article Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study.
Academic Article Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Academic Article Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction.
Academic Article Association of Genetic Variation in Coronary Artery Disease-Related Loci With the Risk of Heart Failure With Preserved Versus Reduced Ejection Fraction.
Academic Article Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.
Academic Article Discovery of novel heart rate-associated loci using the Exome Chip.
Academic Article Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons.
Academic Article A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
Academic Article Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Academic Article Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Academic Article Comparison of Daily Routines Between Middle-aged and Older Participants With and Those Without Diabetes in the Electronic Framingham Heart Study: Cohort Study.
Academic Article No evidence of association between habitual physical activity and ECG traits: Insights from the electronic Framingham Heart Study.
Academic Article The association between social network index, atrial fibrillation, and mortality in the Framingham Heart Study.
Academic Article Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study.
Academic Article Associations Between the Digital Clock Drawing Test and Brain Volume: Large Community-Based Prospective Cohort (Framingham Heart Study).
Academic Article Relations Between BMI Trajectories and Habitual Physical Activity Measured by a Smartwatch in the Electronic Cohort of the Framingham Heart Study: Cohort Study.
Academic Article Identifying Blood Biomarkers for Dementia Using Machine Learning Methods in the Framingham Heart Study.
Academic Article Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.
Academic Article Genetic analysis of right heart structure and function in 40,000 people.
Academic Article The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study.
Academic Article Factors associated with long-term use of digital devices in the electronic Framingham Heart Study.
Academic Article Association Between Acoustic Features and Neuropsychological Test Performance in the Framingham Heart Study: Observational Study.
Academic Article Increasing Engagement in the Electronic Framingham Heart Study: Factorial Randomized Controlled Trial.
Academic Article Obesity impacts the expression of Alzheimer's disease-related genes: The Framingham Heart Study.
Academic Article Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography.
Academic Article The bidirectional association between atrial fibrillation and myocardial infarction.
Academic Article Association of Depressive Symptom Trajectory With Physical Activity Collected by mHealth Devices in the Electronic Framingham Heart Study: Cohort Study.
Academic Article Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings: The Framingham Heart Study.
Academic Article Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study.
Academic Article Multimodal Machine Learning for 10-Year Dementia Risk Prediction: The Framingham Heart Study.
Academic Article Association Between Acoustic Features and Brain Volumes: the Framingham Heart Study
Academic Article Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts.
Academic Article Design and Feasibility Analysis of a Smartphone-Based Digital Cognitive Assessment Study in the Framingham Heart Study.
Academic Article Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study.
Academic Article Shifting From Active to Passive Monitoring of Alzheimer Disease: The State of the Research.
Academic Article Exploring cognitive progression subtypes in the Framingham Heart Study.
Academic Article Bidirectional Association Between Atrial Fibrillation and Myocardial Infarction, and Relation to Mortality in the Framingham Heart Study.
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  • Heart