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One or more keywords matched the following properties of Lin, Honghuang
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I am a bioinformatician/biostatistician with training in mathematics, machine learning, genetics, and digital medicine. Our lab is mainly focused on the development and application of computational tools to study complex diseases. 

  1. Identification of genetic causes of complex diseases. We have been involved in multiple large-scale genetic consortiums, such as the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Trans-Omics for Precision Medicine (TOPMed) program, and Alzheimer's Disease Sequencing Project (ADSP). These studies have identified hundreds of genetic loci associated with atrial fibrillation, heart failure, hypertension, and Alzheimer’s disease.
  2. Integration of multi-omics data to understand disease molecular mechanisms. Complex diseases are usually caused by the interplay of genetic and environmental factors. We have identified numerous molecular signatures from gene expression, protein expression, and DNA methylation that are related to aging and cardiovascular disease. We are also developing computational methods to integrate different molecular signatures and build gene interaction networks to study potential disease regulation networks.
  3. Development of machine learning models for early disease diagnosis. We have built multiple machine learning models to predict dementia risk from midlife risk factors and neuropsychological tests. In combination with neuroimaging and blood-based measures, we are also developing multimodal machine learning methods to identify new biomarkers that are predictive of future cognitive impairment.
  4. Exploration of digital and wearable devices for health monitoring. We have deployed thousands of wearable devices and mobile apps to monitor cardiovascular health and cognitive health. We are integrating active engagement with passive engagement technologies from the habitual environment to make sustained monitoring feasible. Novel analytic strategies are also being developed to analyze big unstructured data to identify potential digital biomarkers that are predictive of future health outcomes.
One or more keywords matched the following items that are connected to Lin, Honghuang
Item TypeName
Academic Article Atrial fibrillation: current knowledge and future directions in epidemiology and genomics.
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Academic Article Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese.
Academic Article Whole blood gene expression and atrial fibrillation: the Framingham Heart Study.
Academic Article Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).
Academic Article Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation.
Academic Article MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage.
Academic Article Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study.
Academic Article Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study.
Academic Article Association of Habitual Physical Activity With Cardiovascular Disease Risk.
Academic Article Adherence of Mobile App-Based Surveys and Comparison With Traditional Surveys: eCohort Study.
Academic Article Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential.
Academic Article P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study.
Academic Article Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits.
Academic Article Novel Risk Modeling Approach of Atrial Fibrillation With Restricted Mean Survival Times: Application in the Framingham Heart Study Community-Based Cohort.
Academic Article Protein Biomarkers and Risk of Atrial Fibrillation: The FHS.
Academic Article Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Academic Article Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort.
Academic Article Measures of Biologic Age in a Community Sample Predict Mortality and Age-Related Disease: The Framingham Offspring Study.
Academic Article Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization.
Academic Article Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
Academic Article Epigenetic Age and the Risk of Incident Atrial Fibrillation.
Academic Article New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation.
Academic Article Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross-Sectional Analysis of the Plasma Proteome in the Framingham Heart Study.
Academic Article Transcriptomic Heterogeneity of Alzheimer's Disease Associated with Lipid Genetic Risk.
Academic Article PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.
Academic Article Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study.
Academic Article Association of Genetic Variation in Coronary Artery Disease-Related Loci With the Risk of Heart Failure With Preserved Versus Reduced Ejection Fraction.
Academic Article Familial clustering of hypertensive target organ damage in the community.
Academic Article Discovery of novel heart rate-associated loci using the Exome Chip.
Academic Article Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles.
Academic Article Association of exome sequences with plasma C-reactive protein levels in >9000 participants.
Academic Article A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
Academic Article Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing.
Academic Article The association between social network index, atrial fibrillation, and mortality in the Framingham Heart Study.
Academic Article Neck Circumference and Risk of Incident Atrial Fibrillation in the Framingham Heart Study.
Academic Article Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.
Academic Article Design and Preliminary Findings of Adherence to the Self-Testing for Our Protection From COVID-19 (STOP COVID-19) Risk-Based Testing Protocol: Prospective Digital Study.
Academic Article Step Count, Self-reported Physical Activity, and Predicted 5-Year Risk of Atrial Fibrillation: Cross-sectional Analysis.
Academic Article Obesity impacts the expression of Alzheimer's disease-related genes: The Framingham Heart Study.
Academic Article The bidirectional association between atrial fibrillation and myocardial infarction.
Academic Article Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings: The Framingham Heart Study.
Academic Article Multimodal Machine Learning for 10-Year Dementia Risk Prediction: The Framingham Heart Study.
Academic Article Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study.
Academic Article Bidirectional Association Between Atrial Fibrillation and Myocardial Infarction, and Relation to Mortality in the Framingham Heart Study.
Academic Article Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci.
Academic Article The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals.
Academic Article The AORTA Gene score for detection and risk stratification of ascending aortic dilation.
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