Sign in to edit your profile (add interests, mentoring, photo, etc.)
    Keywords
    Last Name
    Institution

    Eric H Baehrecke PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentCancer Biology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-6733
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCancer Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentBioinformatics and Integrative Biology

        Overview 
        Narrative

        Cell Death and Autophagy

        Our laboratory studies the mechanisms that regulate autophagy, cell survival and programmed cell death EricBaehrecke inthe context of normal and abnormal development. Altered autophagy, cell survival and cell death are associated with a variety of human disorders including cancer. We use global genomic approaches, including DNA microarrays, proteomics and forward genetic screens,to identify genes and proteins involved in programmed cell death and development. The Drosophila model system allows us to functionally validate our gene discovery, and also enables the identification of novel genes using forward genetic screens. Our studies have focused on steroid activation of cell death, and the role of autophagy and other degradation mechanisms during cell survival and death.

        Steroid Activation of Programmed Cell Death

        At least two morphological forms of programmed cell killing occur during development of all higher animals. While much is known about apoptotic cell death, little is known about autophagic cell death. Autophagic cell death in Drosophila salivary glands involves the activation of diverse protein degradation programs that include both caspases and autophagy. Fly salivary glands provide an in vivo genetic model system for elucidating the complex functions of autophagy in cell survival and cell death during development.

        The steroid hormone ecdysone triggers salivary gland cell death by activation of a two-step nuclear hormone receptor-activated gene transcription hierarchy (Figure 1). The ecdysone receptor, encoded by the nuclear receptors EcR and Usp, in the presence of the competence factor ßFTZ-F1, triggers the first step in this hierarchy by activating transcription of BR-C, E74, and E93. Mutations in each of these transcriptional regulators prevent the death of salivary glands, and alter transcription of secondary response genes that carry out the cell death program. By analyzing mutants with phenotypes similar to those seen in BR-C, E74 and E93 mutants, we expect to identify novel cell death regulatory molecules.

        Our microarray analysis demonstrated the robust nature of this steroid-triggered transcriptional hierarchy through the identification of genes known to function in apoptosis but which had not been previously associated with autophagic cell death, as well as many candidate BR-C, E74 and E93 target genes. Although autophagic cell death is morphologically distinct from apoptosis, our studies have shown that during autophagic death of salivary glands, caspases are activated and caspase substrates are cleaved, suggesting that much of the apoptotic machinery is utilized during autophagic cell death. Our microarray and proteomics analyses also indicate that several caspase-independent protein degradation mechanisms including matrix metallo-protease, serine protease and autophagy RNAs and proteins are expressed during cell death. Projects in the Baehrecke lab are aimed toward understanding how steroid-triggered transcription factors regulate secondary response gene transcription, and how these multiple protein degradation programs are coordinated to mediate programmed cell death.

        Degradation of Dying Cells by Autophagy

        Although our studies indicate that much of the apoptotic machinery is utilized during autophagic cell death, dying salivary glands are destroyed without the association of engulfing phagocytes that are necessary for the removal of cell corpses during apoptosis. This indicates that salivary gland cells contain the machinery needed to dismantle and recycle their own cellular components, and this is supported by the presence of autophagic vacuoles (also known as autophagosomes) in the cytoplasm of salivary gland cells. Autophagic vacuoles are a hallmark of autophagy, a conserved catabolic process that functions in the degradation of long-lived proteins and in organelle turnover and recycling (Figure 2).

        The role of autophagy during cell death remains controversial. It is important to understand the relationship between autophagy and cell death, as the association of autophagy with cell growth, nutrient utilization, survival and death indicates that this catabolic process is relevant to the treatment of many human disorders including cancer. Our recent studies indicate that autophagy is required for degradation of dying salivary glands during Drosophila development. In collaboration with Michael Lenardo at the National Institutes of Health, we have shown that autophagy is required for the caspase-independent death in mammalian cells. In contrast, our work in collaboration with Paul Taylor at the University of Pennsylvania has shown that autophagy is protective in a fly model of polyglutamine-induced neurodegeneration. Phosphoinositide 3-kinase (PI3K) pathways regulate cell growth, cell death and autophagy, but the mechanisms that coordinate these cell processes remains uncertain. We are investigating the role(s) of autophagy in cell growth and cell death, and how steroids and PI3K signaling mechanisms are integrated to regulate autophagy in the context of development (Figure 3). As in our studies of neurodegeneration, we hope to extend our studies of the genes that are required for autophagy and cell death in fly salivary glands into models of cancer.

        EBfigures



        Post Docs

        Postdoctoral positions are available for this lab. Please contact Eric Baehrecke directly, 508-856-6733 or via email, Eric.Baehrecke@umassmed.edu



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Chang TK, Shravage BV, Hayes SD, Powers CM, Simin RT, Wade Harper J, Baehrecke EH. Uba1 functions in Atg7- and Atg3-independent autophagy. Nat Cell Biol. 2013 Sep; 15(9):1067-78.
          View in: PubMed
        2. Shravage BV, Hill JH, Powers CM, Wu L, Baehrecke EH. Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila. Development. 2013 Mar; 140(6):1321-9.
          View in: PubMed
        3. Tracy K, Baehrecke EH. The role of autophagy in Drosophila metamorphosis. Curr Top Dev Biol. 2013; 103:101-25.
          View in: PubMed
        4. McPhee CK, Balgley BM, Nelson C, Hill JH, Batlevi Y, Fang X, Lee CS, Baehrecke EH. Identification of factors that function in Drosophila salivary gland cell death during development using proteomics. Cell Death Differ. 2013 Feb; 20(2):218-25.
          View in: PubMed
        5. Das G, Shravage BV, Baehrecke EH. Regulation and Function of Autophagy during Cell Survival and Cell Death. Cold Spring Harb Perspect Biol. 2012; 4(6).
          View in: PubMed
        6. Denton D, Chang TK, Nicolson S, Shravage B, Simin R, Baehrecke EH, Kumar S. Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ. 2012 Aug; 19(8):1299-307.
          View in: PubMed
        7. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, Ghosh P, Giammarioli AM, Giatromanolaki AN, Gibson SB, Gilkerson RW, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
          View in: PubMed
        8. Mou X, Duncan DM, Baehrecke EH, Duncan I. Control of target gene specificity during metamorphosis by the steroid response gene E93. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2949-54.
          View in: PubMed
        9. Chan FK, Baehrecke EH. RIP3 Finds Partners in Crime. Cell. 2012 Jan 20; 148(1-2):17-8.
          View in: PubMed
        10. Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov 1; 7(11):1273-94.
          View in: PubMed
        11. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nuñez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012 Jan; 19(1):107-20.
          View in: PubMed
        12. Rong Y, McPhee CK, McPhee C, Deng S, Huang L, Chen L, Liu M, Tracy K, Baehrecke EH, Baehreck EH, Yu L, Lenardo MJ. Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7826-31.
          View in: PubMed
        13. Nezis IP, Shravage BV, Sagona AP, Johansen T, Baehrecke EH, Stenmark H. Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila. Autophagy. 2010 Nov 16; 6(8):1214-5.
          View in: PubMed
        14. McPhee CK, Baehrecke EH. The engulfment receptor Draper is required for autophagy during cell death. Autophagy. 2010 Nov 16; 6(8):1192-3.
          View in: PubMed
        15. Ryoo HD, Baehrecke EH. Distinct death mechanisms in Drosophila development. Curr Opin Cell Biol. 2010 Dec; 22(6):889-95.
          View in: PubMed
        16. Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjørkøy G, Johansen T, Rusten TE, Brech A, Baehrecke EH, Stenmark H. Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol. 2010 Aug 23; 190(4):523-31.
          View in: PubMed
        17. McPhee CK, Logan MA, Freeman MR, Baehrecke EH. Activation of autophagy during cell death requires the engulfment receptor Draper. Nature. 2010 Jun 24; 465(7301):1093-6.
          View in: PubMed
        18. McPhee CK, Baehrecke EH. Autophagy shows its animal side. Cell. 2010 Jun 11; 141(6):922-4.
          View in: PubMed
        19. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010 Jun 17; 465(7300):942-6.
          View in: PubMed
        20. Denton D, Shravage B, Simin R, Baehrecke EH, Kumar S. Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy. Autophagy. 2010 Jan; 6(1):163-5.
          View in: PubMed
        21. Batlevi Y, Martin DN, Pandey UB, Simon CR, Powers CM, Taylor JP, Baehrecke EH. Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):742-7.
          View in: PubMed
        22. Denton D, Shravage B, Simin R, Mills K, Berry DL, Baehrecke EH, Kumar S. Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol. 2009 Nov 3; 19(20):1741-6.
          View in: PubMed
        23. Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug; 16(8):1093-107.
          View in: PubMed
        24. McPhee CK, Baehrecke EH. Autophagy in Drosophila melanogaster. Biochim Biophys Acta. 2009 Sep; 1793(9):1452-60.
          View in: PubMed
        25. Baehrecke EH. Autophagy SEPArates germline and somatic cells. Cell. 2009 Jan 23; 136(2):207-8.
          View in: PubMed
        26. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 2009 Jan; 16(1):3-11.
          View in: PubMed
        27. Dutta S, Baehrecke EH. Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila. Curr Biol. 2008 Oct 14; 18(19):1466-75.
          View in: PubMed
        28. Juhász G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol. 2008 May 19; 181(4):655-66.
          View in: PubMed
        29. Neufeld TP, Baehrecke EH. Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila. Autophagy. 2008 Jul 1; 4(5):557-62.
          View in: PubMed
        30. Berry DL, Baehrecke EH. Autophagy functions in programmed cell death. Autophagy. 2008 Apr 1; 4(3):359-60.
          View in: PubMed
        31. Berry DL, Baehrecke EH. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell. 2007 Dec 14; 131(6):1137-48.
          View in: PubMed
        32. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb 16; 4(2):151-75.
          View in: PubMed
        33. Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy. 2007 Nov-Dec; 3(6):643-5.
          View in: PubMed
        34. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature. 2007 Jun 14; 447(7146):859-63.
          View in: PubMed
        35. Martin DN, Balgley B, Dutta S, Chen J, Rudnick P, Cranford J, Kantartzis S, DeVoe DL, Lee C, Baehrecke EH. Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development. Cell Death Differ. 2007 May; 14(5):916-23.
          View in: PubMed
        36. Baehrecke EH. Growth control: p53, the guardian angel of compensatory proliferation. Curr Biol. 2006 Oct 10; 16(19):R840-2.
          View in: PubMed
        37. Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, Hay BA. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 2006 Sep; 133(17):3305-15.
          View in: PubMed
        38. Fortier TM, Chatterjee R, Klinedinst S, Baehrecke EH, Woodard CT. How functions in leg development during Drosophila metamorphosis. Dev Dyn. 2006 Aug; 235(8):2248-59.
          View in: PubMed
        39. Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, Baehrecke EH, Lenardo M. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4952-7.
          View in: PubMed
        40. Debnath J, Baehrecke EH, Kroemer G. Does autophagy contribute to cell death? Autophagy. 2005 Jul; 1(2):66-74.
          View in: PubMed
        41. Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol. 2005 Jun; 6(6):505-10.
          View in: PubMed
        42. Yu L, Lenardo MJ, Baehrecke EH. Autophagy and caspases: a new cell death program. Cell Cycle. 2004 Sep; 3(9):1124-6.
          View in: PubMed
        43. Alva AS, Gultekin SH, Baehrecke EH. Autophagy in human tumors: cell survival or death? Cell Death Differ. 2004 Sep; 11(9):1046-8.
          View in: PubMed
        44. Baehrecke EH, Dang N, Babaria K, Shneiderman B. Visualization and analysis of microarray and gene ontology data with treemaps. BMC Bioinformatics. 2004 Jun 28; 5:84.
          View in: PubMed
        45. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004 Jun 4; 304(5676):1500-2.
          View in: PubMed
        46. Martin DN, Baehrecke EH. Caspases function in autophagic programmed cell death in Drosophila. Development. 2004 Jan; 131(2):275-84.
          View in: PubMed
        47. Baehrecke EH. Autophagic programmed cell death in Drosophila. Cell Death Differ. 2003 Sep; 10(9):940-5.
          View in: PubMed
        48. Baehrecke EH. miRNAs: micro managers of programmed cell death. Curr Biol. 2003 Jun 17; 13(12):R473-5.
          View in: PubMed
        49. Baehrecke EH. Caspase activation finds fertile ground. Dev Cell. 2003 May; 4(5):608-9.
          View in: PubMed
        50. Oberst A, Baehrecke E, Mehmet H, Ichijo H, Gupta S. A place to die for: apoptosis in cancer and infection, Capri 2002. Cell Death Differ. 2003 Mar; 10(3):393-5.
          View in: PubMed
        51. Lee CY, Clough EA, Yellon P, Teslovich TM, Stephan DA, Baehrecke EH. Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Curr Biol. 2003 Feb 18; 13(4):350-7.
          View in: PubMed
        52. Lee CY, Simon CR, Woodard CT, Baehrecke EH. Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Dev Biol. 2002 Dec 1; 252(1):138-48.
          View in: PubMed
        53. Baehrecke EH. How death shapes life during development. Nat Rev Mol Cell Biol. 2002 Oct; 3(10):779-87.
          View in: PubMed
        54. Lee CY, Cooksey BA, Baehrecke EH. Steroid regulation of midgut cell death during Drosophila development. Dev Biol. 2002 Oct 1; 250(1):101-11.
          View in: PubMed
        55. Chen J, Lee CS, Shen Y, Smith RD, Baehrecke EH. Integration of capillary isoelectric focusing with capillary reversed-phase liquid chromatography for two-dimensional proteomics separation. Electrophoresis. 2002 Sep; 23(18):3143-8.
          View in: PubMed
        56. Cakouros D, Daish T, Martin D, Baehrecke EH, Kumar S. Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex. J Cell Biol. 2002 Jun 10; 157(6):985-95.
          View in: PubMed
        57. Lee CY, Baehrecke EH. Steroid regulation of autophagic programmed cell death during development. Development. 2001 Apr; 128(8):1443-55.
          View in: PubMed
        58. Baehrecke EH. Steroid regulation of programmed cell death during Drosophila development. Cell Death Differ. 2000 Nov; 7(11):1057-62.
          View in: PubMed
        59. Lee CY, Baehrecke EH. Genetic regulation of programmed cell death in Drosophila. Cell Res. 2000 Sep; 10(3):193-204.
          View in: PubMed
        60. Lee CY, Wendel DP, Reid P, Lam G, Thummel CS, Baehrecke EH. E93 directs steroid-triggered programmed cell death in Drosophila. Mol Cell. 2000 Aug; 6(2):433-43.
          View in: PubMed
        61. van den Eijnde SM, Boshart L, Baehrecke EH, De Zeeuw CI, Reutelingsperger CP, Vermeij-Keers C. Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved. Apoptosis. 1998; 3(1):9-16.
          View in: PubMed
        62. Jiang C, Baehrecke EH, Thummel CS. Steroid regulated programmed cell death during Drosophila metamorphosis. Development. 1997 Nov; 124(22):4673-83.
          View in: PubMed
        63. Baehrecke EH. who encodes a KH RNA binding protein that functions in muscle development. Development. 1997 Apr; 124(7):1323-32.
          View in: PubMed
        64. Baehrecke EH. Ecdysone signaling cascade and regulation of Drosophila metamorphosis. Arch Insect Biochem Physiol. 1996; 33(3-4):231-44.
          View in: PubMed
        65. Baehrecke EH, Thummel CS. The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone. Dev Biol. 1995 Sep; 171(1):85-97.
          View in: PubMed
        66. Woodard CT, Baehrecke EH, Thummel CS. A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone. Cell. 1994 Nov 18; 79(4):607-15.
          View in: PubMed
        67. Baehrecke EH, Aiken JM, Dover BA, Strand MR. Ecdysteroid induction of embryonic morphogenesis in a parasitic wasp. Dev Biol. 1993 Aug; 158(2):275-87.
          View in: PubMed
        68. Williams HJ, Scott AI, Woolfenden WR, Grant DM, Vinison SB, Elzen GW, Baehrecke EH. In vivo and solid state 13C nuclear magnetic resonance studies of tyrosine metabolism during insect cuticle formation. Comp Biochem Physiol B. 1988; 89(2):317-21.
          View in: PubMed
        For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
        Eric's Networks
        Click the "See All" links for more information and interactive visualizations!
        Concepts
        _
        Co-Authors
        _
        Similar People
        _
        Same Department
        Physical Neighbors
        _

        This is an official Page/Publication of the University of Massachusetts Worcester Campus
        Office of the Vice Provost for Research, 55 Lake Ave North, Worcester, Massachusetts 01655
        Questions or Comments? Email: publicaffairs@umassmed.edu Phone: 508-856-1572