Autophagy

"Autophagy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The segregation and degradation of cytoplasmic constituents by AUTOPHAGOSOMES and their digestion by LYSOSOMES. It plays an important role in BIOLOGICAL METAMORPHOSIS and in the removal of bone by OSTEOCLASTS. Defective autophagy is associated with various diseases, including NEURODEGENERATIVE DISEASES and cancer.

Descriptor ID	D001343
MeSH Number(s)	G04.146.399 G04.417.350.091
Concept/Terms	Autophagy Autophagy Autophagies Macro-autophagy Macro autophagy Macro-autophagies Autophagy, Cellular Autophagies, Cellular Cellular Autophagies Cellular Autophagy Macroautophagy Macroautophagies Autophagocytosis Programmed Cell Death, Type II Programmed Cell Death, Type II Autophagic Cell Death Autophagic Cell Deaths Cell Death, Autophagic Cell Deaths, Autophagic Death, Autophagic Cell Deaths, Autophagic Cell Autophagic Programmed Cell Death

Below are MeSH descriptors whose meaning is more general than "Autophagy".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Death [G04.146]
Autophagy [G04.146.399]
Endocytosis [G04.417]
Phagocytosis [G04.417.350]
Autophagy [G04.417.350.091]

Below are MeSH descriptors whose meaning is related to "Autophagy".

Below are MeSH descriptors whose meaning is more specific than "Autophagy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Autophagy" by people in this website by year, and whether "Autophagy" was a major or minor topic of these publications.

Bar chart showing 202 publications over 26 distinct years, with a maximum of 17 publications in 2013 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	1	2
2001	1	0	1
2003	3	1	4
2004	3	0	3
2005	2	0	2
2006	1	0	1
2007	7	0	7
2008	6	3	9
2009	5	2	7
2010	10	3	13
2011	11	1	12
2012	13	0	13
2013	12	5	17
2014	10	2	12
2015	6	2	8
2016	9	8	17
2017	6	2	8
2018	9	6	15
2019	6	2	8
2020	6	3	9
2021	6	4	10
2022	1	3	4
2023	3	4	7
2024	4	3	7
2025	0	2	2
2026	2	2	4

Below are the most recent publications written about "Autophagy" by people in Profiles.

Labadie BW, Obradovic A, Raufi AG, Wasko UN, Tomassoni L, Ge L, May M, Vij M, Li L, Ross I, Sedycius SS, Sender N, Dreher N, Wu L, Abuzaid S, Iuga A, Shah P, Wulfkuhle JD, Bates S, Wong W, Pellicciotta I, Lyashchenko AK, Safran H, Izar B, Petricoin EF, Cremers S, Tan AC, Lee S, Califano A, Olive KP, Manji GA. Targeting of MEK and Autophagy in Pancreatic Adenocarcinoma and Analysis of Treatment Sensitivity in Preclinical and Clinical Models: MEKiAUTO. JCO Precis Oncol. 2026 Jun; 10(6):e2600138.

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Bilger MD, Berridge BR, Hendricks GM, Martinez-Romero EG, Mitchell RN, Reddig KR, Rush JE, Freeman LM. Ultrastructural differences in the myocardium of cats with dilated cardiomyopathy eating high- versus low-pulse diets. Ultrastruct Pathol. 2026; 50(2):196-205.

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Udinia S, Das M, Jamwal S, Markandey M, Bajaj A, Mehra L, Kedia S, Lim CFH, Foo S, Das P, Howland S, Suar M, Singhal A, Ahuja V, Kumar D. AXL-dependent autophagy impairment differentiates monocyte-derived macrophages from Crohn's disease and intestinal tuberculosis. Indian J Gastroenterol. 2026 Jun; 45(3):592-603.

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Restrepo LJ, Graslie JK, Fortier TM, Baehrecke EH. The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development. PLoS Biol. 2026 Jan; 24(1):e3003616.

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Wang R, Baehrecke EH. Atg9 is a conserved regulator of lysosome repair. J Cell Biol. 2025 07 07; 224(7).

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Simwela NV, Jaecklein E, Sassetti CM, Russell DG. Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis. Elife. 2025 Mar 13; 13.

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Simwela NV, Johnston L, Bitar PP, Jaecklein E, Altier C, Sassetti CM, Russell DG. Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth. Nat Commun. 2024 10 29; 15(1):9322.

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Sweet MJ, Ramnath D, Singhal A, Kapetanovic R. Inducible antibacterial responses in macrophages. Nat Rev Immunol. 2025 Feb; 25(2):92-107.

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Mittal E, Prasad GVRK, Upadhyay S, Sadadiwala J, Olive AJ, Yang G, Sassetti CM, Philips JA. Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice. Nat Microbiol. 2024 Nov; 9(11):2970-2984.

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Colino-Lage H, Guerrero-G?mez D, G?mez-Orte E, Gonz?lez X, Martina JA, Dansen TB, Ayuso C, Askjaer P, Puertollano R, Irazoqui JE, Cabello J, Miranda-Vizuete A. Regulation of Caenorhabditis elegans HLH-30 subcellular localization dynamics: Evidence for a redox-dependent mechanism. Free Radic Biol Med. 2024 Oct; 223:369-383.

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