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    Lloyd Hutchinson PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    One Innovation Drive, Biotech Three
    Worcester MA 01605
    Phone508-793-6240
        Overview 
        Narrative

        Academic Background:

        BS -1987, Microbiology and Chemistry, Univ. of Guelph, Guelph ON Canada

        PhD.- 1996, Molecular Virology and Immunology, McMaster Univ., Hamilton ON Canada

        Postdoctoral Fellow -2004, Molecular Oncology, Vascular Biology Program, Children’s Hospital, Harvard Medical School, Boston MA

        Research Interests :Dr. Hutchinson's picture

        My research encompasses tumor biology including hematopathology and solid tumors. A primary focus is the discovery and development of novel technology and cancer biomarkers for early cancer detection. The eventual goal is to provide oncologists with tools that enable early intervention and better outcomes for patients. Diagnostic assays and biomarkers in development may be used for early detection, to assist in diagnosis, prognosis, and treatment decisions or to monitor levels of minimal residual disease



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Fischer AH, Hutchinson LM. Technical and US regulatory issues in triaging material for the molecular laboratory. Cancer Cytopathol. 2016 Sep 6.
          View in: PubMed
        2. Cornejo KM, Hutchinson L, Meng X, O'Donnell P, Deng A. Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid: A Report of a Case With Molecular Analysis. Am J Dermatopathol. 2016 Aug; 38(8):636-8.
          View in: PubMed
        3. Magotra M, Sakhdari A, Lee PJ, Tomaszewicz K, Dresser K, Hutchinson LM, Woda BA, Chen BJ. Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukemia: Relationship to somatic gene mutations affecting epigenetic pathways. Histopathology. 2016 Jul 26.
          View in: PubMed
        4. Liu Q, Tomaszewicz K, Hutchinson L, Hornick JL, Woda B, Yu H. Somatic mutations in histiocytic sarcoma identified by next generation sequencing. Virchows Arch. 2016 Aug; 469(2):233-41.
          View in: PubMed
        5. Zhou AG, Liu Y, Cyr MS, Garver J, Woda BA, Cosar EF, Hutchinson LM. Role of Tetrasomy for the Diagnosis of Urothelial Carcinoma Using UroVysion Fluorescent In Situ Hybridization. Arch Pathol Lab Med. 2016 Jun; 140(6):552-9.
          View in: PubMed
        6. Kamionek M, Ahmadi Moghaddam P, Sakhdari A, Kovach AE, Welch M, Meng X, Dresser K, Tomaszewicz K, Cosar EF, Mark EJ, Fraire AE, Hutchinson L. Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease. Histopathology. 2016 Sep; 69(3):499-509.
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        7. Fang M, Hutchinson L, Deng A, Green MR. Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma. Proc Natl Acad Sci U S A. 2016 Feb 2; 113(5):1250-5.
          View in: PubMed
        8. Cornejo KM, Hutchinson L, Cyr MS, Nose V, McLaughlin PJ, Iafrate AJ, Sadow PM. MYC Analysis by Fluorescent In Situ Hybridization and Immunohistochemistry in Primary Adrenal Angiosarcoma (PAA): a Series of Four Cases. Endocr Pathol. 2015 Dec; 26(4):334-41.
          View in: PubMed
        9. Zhou AG, Hutchinson L, Cosar EF. 2015. Ancillary Tests for the Detection of Urothelial Carcinoma. In Xiaoqi Lin, Longwen Chen, Ritu Nayar, editors. Cytology, Histology, Cystoscopy, and Radiology of the Urinary System Atlas and Practical Guide. Peoples Medical Publishing House-USA. ISBN 978-1-60795-185-8. 2015.
        10. Sakhdari A, Hutchinson L, Cosar EF. 2015. Chapter 7: Molecular Pathology of Lobular Carcinoma. Chapter 9: Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2. Evaluation and Role in Targeted Therapy. Chapter 19: Specimens for Molecular Testing in Breast Cancer . In Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors. Molecular Pathology Library, Volume 10. Precision Molecular Pathology of Breast Cancer. Springer, New York, p. 95,119,317. DOI: http://dx.doi.org/10.1007/978-1-4939-2886-6. 2015.
        11. Cornejo KM, Deng A, Wu H, Cosar EF, Khan A, St Cyr M, Tomaszewicz K, Dresser K, O'Donnell P, Hutchinson L. The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast. Hum Pathol. 2015 Jun; 46(6):868-75.
          View in: PubMed
        12. Fang M, Ou J, Hutchinson L, Green MR. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell. 2014 Sep 18; 55(6):904-15.
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        13. Ma L, Shan Y, Bai R, Xue L, Eide CA, Ou J, Zhu LJ, Hutchinson L, Cerny J, Khoury HJ, Sheng Z, Druker BJ, Li S, Green MR. A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia. Sci Transl Med. 2014 Sep 3; 6(252):252ra121.
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        14. Rosenblum F, Hutchinson LM, Garver J, Woda B, Cosar E, Kurian EM. Cytology specimens offer an effective alternative to formalin-fixed tissue as demonstrated by novel automated detection for ALK break-apart FISH testing and immunohistochemistry in lung adenocarcinoma. Cancer Cytopathol. 2014 Nov; 122(11):810-21.
          View in: PubMed
        15. Lee, P.J., Owens, C.L., Hutchinson, L., Fischer, A.H. Intranuclear cytoplasmic inclusions are a specific feature of intraductal papillary mucinous neoplasms that distinguish contaminating gastric epithelium. DOI: http://dx.doi.org/10.1016/j.jasc.2013.12.003. Journal of the American Society of Cytopathology. 2014; 3(2):108-113.
        16. Serra RW, Fang M, Park SM, Hutchinson L, Green MR. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014; 3:e02313.
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        17. Wu X, Tomaszewicz K, Hutchinson L, Cosar E, Deng A. . Next Generation Sequencing in Differential Diagnosis of Childhood Melanoma from Spitz Nevus: A case report. DOI: http://ijcp.elmerpress.com/index.php/ijcp/article/view/152/108. International Journal of Clinical Pediatrics. 2014; 3(1):22-28..
        18. Zhou AG, Hutchinson LM, Cosar EF. Urine Cytopathology and Ancillary Methods (Review). DOI: http://dx.doi.org/10.1016/j.path.2013.10.003. Surgical Pathology Clinics. 2014; 7(1):77-88.
        19. Cornejo KM, Hutchinson L, Deng A, Tomaszewicz K, Welch M, Lyle S, Dresser K, Cosar EF. BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis. Hum Pathol. 2014 Jun; 45(6):1213-20.
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        20. Ramanathan M, Cerny J, Tomaszewicz K, Hutchinson L, Bednarik J, Woda BA, Nath R. . Isolated Extra Medullary Relapse after Allogeneic Stem Cell Transplant in FLT3 Mutated Acute Myeloid leukemia (AML) While on FLT3 Inhibitor Sorafenib. DOI: http://dx.doi.org/10.4172/2329-8790.1000116. J Hematol Thromb Dis. 2013; 1(4):116.
        21. Zhou AG, Hutchinson LM, Cosar EF. Urine Cytopathology and Ancillary Methods. Surg Pathol Clin. 2014 Mar; 7(1):77-88.
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        22. Cornejo KM, Hutchinson L, Cosar EF, Smith T, Tomaszewicz K, Dresser K, Deng A. Is it a primary or metastatic melanocytic neoplasm of the central nervous system?: A molecular based approach. Pathol Int. 2013 Nov; 63(11):559-64.
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        23. Wang SA, Hutchinson L, Tang G, Chen SS, Miron PM, Huh YO, Jones DM, Bueso-Ramos C, Verstovsek S, Medeiros LJ, Miranda RN. Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD components. Am J Hematol. 2013 Mar; 88(3):219-24.
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        24. Menon MP, Hutchinson L, Garver J, Jaffe ES, Woda BA. Transformation of follicular lymphoma to Epstein-Barr virus-related Hodgkin-like lymphoma. J Clin Oncol. 2013 Feb 10; 31(5):e53-6.
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        25. Cerny J, Yu H, Ramanathan M, Raffel GD, Walsh WV, Fortier N, Shanahan L, O'Rourke E, Bednarik J, Barton B, Kroll-Desrosiers A, Hao S, Woda B, Hutchinson L, Evens AM, Rosmarin AG, Nath R. Expression of CD25 independently predicts early treatment failure of acute myeloid leukaemia (AML). Br J Haematol. 2013 Jan; 160(2):262-6.
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        26. Zhang H, Peng C, Hu Y, Li H, Sheng Z, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Zhang X, Brehm MA, Li D, Green MR, Li S. The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet. 2012 Aug; 44(8):861-71.
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        27. Piperdi B, Walsh WV, Bradley K, Zhou Z, Bathini V, Hanrahan-Boshes M, Hutchinson L, Perez-Soler R. Phase-I/II study of bortezomib in combination with carboplatin and bevacizumab as first-line therapy in patients with advanced non-small-cell lung cancer. J Thorac Oncol. 2012 Jun; 7(6):1032-40.
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        28. Hure MC, Elco CP, Ward D, Hutchinson L, Meng X, Dorfman DM, Yu H. Histiocytic sarcoma arising from clonally related mantle cell lymphoma. J Clin Oncol. 2012 Feb 10; 30(5):e49-53.
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        29. Kurian EM, Caporelli ML, Baker S, Woda B, Cosar EF, Hutchinson L. Cervista HR and HPV 16/18 assays vs hybrid capture 2 assay: outcome comparison in women with negative cervical cytology. Am J Clin Pathol. 2011 Nov; 136(5):808-16.
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        30. Dvorak K, Goldman A, Kong J, Lynch JP, Hutchinson L, Houghton JM, Chen H, Chen X, Krishnadath KK, Westra WM. Molecular mechanisms of Barrett's esophagus and adenocarcinoma. Ann N Y Acad Sci. 2011 Sep; 1232:381-91.
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        31. Shi M, Miron PM, Hutchinson L, Woda BA, Nath R, Cerny J, Yu H. Anaplastic lymphoma kinase-positive large B-cell lymphoma with complex karyotype and novel ALK gene rearrangements. Hum Pathol. 2011 Oct; 42(10):1562-7.
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        32. Hutchinson L, Stenstrom B, Chen D, Piperdi B, Levey S, Lyle S, Wang TC, Houghton J. Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. Stem Cells Dev. 2011 Jan; 20(1):11-7.
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        33. Cerny J, Wang S, Miron P, Hutchinson L, Brettler D. EBV-negative Hodgkin lymphoma in ZAP-70-positive B-cell lymphocytic leukemia patient. Ann Hematol. 2009 May; 88(5):495-7.
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        34. Cerny J, Fadare O, Hutchinson L, Wang SA. Clinicopathological features of extramedullary recurrence/relapse of multiple myeloma. Eur J Haematol. 2008 Jul; 81(1):65-9.
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        35. Pozdnyakova O, Stachurski D, Hutchinson L, Ramakrishnan S, Miron PM. Trisomy 8 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2008 May; 183(1):49-52.
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        36. Banyard J, Hutchinson LM, Zetter BR. Thymosin beta-NB is the human isoform of rat thymosin beta15. Ann N Y Acad Sci. 2007 Sep; 1112:286-96.
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        37. Wang SA, Yue G, Hutchinson L, Landry ML, Hasserjian RP, Hao S, Galili N, Raza A, Woda BA. Myelodysplastic syndrome with pure red cell aplasia shows characteristic clinicopathological features and clonal T-cell expansion. Br J Haematol. 2007 Jul; 138(2):271-5.
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        38. Stachurski D, Miron PM, Al-Homsi S, Hutchinson L, Harris NL, Woda B, Wang SA. Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3' ALK gene insertion to chromosome 4 q22-24. Hum Pathol. 2007 Jun; 38(6):940-5.
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        39. Banyard J, Bao L, Hofer MD, Zurakowski D, Spivey KA, Feldman AS, Hutchinson LM, Kuefer R, Rubin MA, Zetter BR. Collagen XXIII expression is associated with prostate cancer recurrence and distant metastases. Clin Cancer Res. 2007 May 1; 13(9):2634-42.
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        40. Almog N, Henke V, Flores L, Hlatky L, Kung AL, Wright RD, Berger R, Hutchinson L, Naumov GN, Bender E, Akslen LA, Achilles EG, Folkman J. Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. FASEB J. 2006 May; 20(7):947-9.
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        41. Hutchinson LM, Chang EL, Becker CM, Shih MC, Brice M, DeWolf WC, Gaston SM, Zetter BR. Use of thymosin beta15 as a urinary biomarker in human prostate cancer. Prostate. 2005 Jul 1; 64(2):116-27.
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        42. Hutchinson LM, Chang EL, Becker CM, Ushiyama N, Behonick D, Shih MC, DeWolf WC, Gaston SM, Zetter BR. Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer. Clin Biochem. 2005 Jun; 38(6):558-71.
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        43. Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR. BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation. J Biol Chem. 2001 Aug 10; 276(32):30127-32.
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        44. Eadie JS, Kim SW, Allen PG, Hutchinson LM, Kantor JD, Zetter BR. C-terminal variations in beta-thymosin family members specify functional differences in actin-binding properties. J Cell Biochem. 2000 Mar; 77(2):277-87.
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        45. Hutchinson L, Johnson DC. Herpes simplex virus glycoprotein K promotes egress of virus particles. J Virol. 1995 Sep; 69(9):5401-13.
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        46. Hutchinson L, Roop-Beauchamp C, Johnson DC. Herpes simplex virus glycoprotein K is known to influence fusion of infected cells, yet is not on the cell surface. J Virol. 1995 Jul; 69(7):4556-63.
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        47. Hutchinson L, Graham FL, Cai W, Debroy C, Person S, Johnson DC. Herpes simplex virus (HSV) glycoproteins B and K inhibit cell fusion induced by HSV syncytial mutants. Virology. 1993 Oct; 196(2):514-31.
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        48. Roop C, Hutchinson L, Johnson DC. A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H. J Virol. 1993 Apr; 67(4):2285-97.
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        49. Hutchinson L, Goldsmith K, Snoddy D, Ghosh H, Graham FL, Johnson DC. Identification and characterization of a novel herpes simplex virus glycoprotein, gK, involved in cell fusion. J Virol. 1992 Sep; 66(9):5603-9.
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        50. Hutchinson L, Browne H, Wargent V, Davis-Poynter N, Primorac S, Goldsmith K, Minson AC, Johnson DC. A novel herpes simplex virus glycoprotein, gL, forms a complex with glycoprotein H (gH) and affects normal folding and surface expression of gH. J Virol. 1992 Apr; 66(4):2240-50.
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