High-Throughput Nucleotide Sequencing

"High-Throughput Nucleotide Sequencing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.

Descriptor ID	D059014
MeSH Number(s)	E05.393.760.319
Concept/Terms	High-Throughput Nucleotide Sequencing High-Throughput Nucleotide Sequencing High Throughput Nucleotide Sequencing Nucleotide Sequencing, High-Throughput Sequencing, High-Throughput Nucleotide Massively-Parallel Sequencing Massively-Parallel Sequencing Massively Parallel Sequencing Sequencing, Massively-Parallel Sequencings, Massively-Parallel High-Throughput RNA Sequencing High-Throughput RNA Sequencing High Throughput RNA Sequencing RNA Sequencing, High-Throughput Sequencing, High-Throughput RNA Deep Sequencing Deep Sequencing Deep Sequencings Sequencing, Deep Sequencings, Deep High-Throughput DNA Sequencing High-Throughput DNA Sequencing DNA Sequencing, High-Throughput High Throughput DNA Sequencing High-Throughput DNA Sequencings Sequencing, High-Throughput DNA

Below are MeSH descriptors whose meaning is more general than "High-Throughput Nucleotide Sequencing".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Sequence Analysis [E05.393.760]
High-Throughput Nucleotide Sequencing [E05.393.760.319]

Below are MeSH descriptors whose meaning is related to "High-Throughput Nucleotide Sequencing".

Below are MeSH descriptors whose meaning is more specific than "High-Throughput Nucleotide Sequencing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "High-Throughput Nucleotide Sequencing" by people in this website by year, and whether "High-Throughput Nucleotide Sequencing" was a major or minor topic of these publications.

Bar chart showing 167 publications over 15 distinct years, with a maximum of 25 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	1	4	5
2012	0	12	12
2013	4	7	11
2014	6	19	25
2015	4	11	15
2016	4	17	21
2017	0	14	14
2018	4	11	15
2019	4	10	14
2020	3	7	10
2021	4	6	10
2022	1	3	4
2023	0	2	2
2024	1	3	4
2025	2	3	5

Below are the most recent publications written about "High-Throughput Nucleotide Sequencing" by people in Profiles.

David SS, Pacheco BA, Kishimoto K, Vantine S, Hu K, Liu H, Davis DL, Tran H, Sallis BF, Ali L, Haynes CM, McCormick BA, Zhu LJ, Flavahan WA. Multidimensional third-generation sequencing of modified DNA bases allows interrogation of complex biological systems. Nat Commun. 2025 Jul 01; 16(1):5676.

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Zhang H, Li X, Song D, Yukselen O, Nanda S, Kucukural A, Li JJ, Garber M, Walhout AJM. Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq. Nat Commun. 2025 May 23; 16(1):4785.

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Gustafsson HT, Ferguson L, Galan C, Yu T, Upton H, Kaymak E, Weng Z, Collins K, Rando OJ. Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR. Elife. 2025 Apr 25; 14.

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Khouri MR, Wang B, Pearson LK, Gillis-Smith AJ, Suzuki S, Hutchinson LM, Bindal P, Ramanathan M, Gerber JM, Cerny J, Patel SA. Characteristics and clinical outcomes of patients with myeloid malignancies and cohesin mutations. Cancer. 2025 Apr 15; 131(8):e35846.

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Kim IE, Fola AA, Puig E, Maina TK, Hui ST, Ma H, Zuckerman K, Agwati EO, Leonetti A, Crudale R, Luftig MA, Moormann AM, Oduor C, Bailey JA. Comparison of nanopore with illumina whole genome assemblies of the Epstein-Barr virus in Burkitt lymphoma. Sci Rep. 2025 Mar 31; 15(1):10970.

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Calvo-Roitberg E, Daniels RF, Pai AA. Challenges in identifying mRNA transcript starts and ends from long-read sequencing data. Genome Res. 2024 Nov 20; 34(11):1719-1734.

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Axelsson J, LeBlanc D, Shojaeisaadi H, Meier MJ, Fitzgerald DM, Nachmanson D, Carlson J, Golubeva A, Higgins J, Smith T, Lo FY, Pilsner R, Williams A, Salk J, Marchetti F, Yauk C. Frequency and spectrum of mutations in human sperm measured using duplex sequencing correlate with trio-based de novo mutation analyses. Sci Rep. 2024 10 08; 14(1):23134.

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Huey JD, Abdennur N. Bigtools: a high-performance BigWig and BigBed library in Rust. Bioinformatics. 2024 06 03; 40(6).

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Abdennur N, Fudenberg G, Flyamer IM, Galitsyna AA, Goloborodko A, Imakaev M, Venev SV. Pairtools: From sequencing data to chromosome contacts. PLoS Comput Biol. 2024 May; 20(5):e1012164.

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Weiss ZF, Pyden AD, Jhaveri TA, Kanjilal S. The diagnostic and clinical utility of microbial cell-free DNA sequencing in a real-world setting. Diagn Microbiol Infect Dis. 2023 Oct; 107(2):116004.

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