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    Patrick Emery-Le PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurobiology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-6599
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative
        Mailing Address:
        Patrick Emery, Ph.D.
        University of Massachusetts Medical School
        Department of Neurobiology, LRB-726
        364 Plantation Street
        Worcester, MA 01605 USA
        e-mail: patrick.emery@umassmed.edu

        Academic Background

        Maturité scientifique. Collège Rousseau, Geneva 1987
        Degree in Biology, University of Geneva 1990
        Diploma in Molecular Biology,
        U of Geneva Medical School
        1991
        PhD, U of Geneva Medical School 1996
        Postdoctoral Fellow, Brandeis University 1997-2001
        Research Fellowships,
        Swiss National Science Foundation
        1997-2000


        Patrick's Photo

        Circadian Rhythms and their Synchronization in Drosophila

        Drosophila melanogasteris a powerful model organism for understanding the genetic, molecular and neural bases of animal behaviors. Circadian rhythms are a prime example of behaviors whose molecular and neural foundations have been greatly increased by studies in Drosophila. A biological clock dictates that animals sleep and wake with a ca. 24-hour period, and this is true even when they are kept under constant conditions, without any information from the environment. Using genetic screens, many essential clock proteins (e.g. PER, TIM, figure 1) were identified in Drosophila. It has been shown that homologues of most of these proteins are also involved in generating mammalian circadian rhythms. Human homologues of DrosophilaPER (hPER2) and DBT (hCK-Id) are actually mutated in patients with advanced sleep-phase syndrome. This demonstrates that the discoveries made in Drosophilaare playing a crucial role in understanding human circadian behavior.

        Since the period of circadian rhythms only approximates 24 hours, and since photoperiod changes at most latitudes over the course of the year, it is essential for circadian rhythms to be responsive to environmental light and temperature cues to remain properly phased with the day/night cycle.We are combining the powerful genetics of Drosophilawith behavioral, cell culture, molecular and biochemical approaches to obtain a comprehensive understanding of the mechanisms underlying the synchronization of Drosophila circadian rhythms.

        One of our major goals is to identify the proteins controlling circadian light and temperature responses and understand their function. We are particularly interested in the mechanisms by which CRYPTOCHROME (CRY) - an unusual blue-light photoreceptor - resets the circadian clock (figure 2). Interestingly CRY is expressed directly within the neurons that control circadian behavior and is therefore a deep-brain photoreceptor. In recent years, it has become clear that specific circadian neurons have dedicated function in the control and synchronization of circadian behavior. Therefore, a second major objective of our laboratory is to identify the circadian neurons responsive to light and temperature, and to understand with precision how these neurons contribute to synchronize circadian behavior with the day/night cycle.

        In summary, our work is aimed at discovering the molecular and neural mechanisms underlying the synchronization of circadian rhythms with light and temperature cycles.Our ultimate goal is to understand how circadian clocks integrate these different inputs to optimize daily animal physiology and behavior.

        Figures

        fig 1

        Figure 3.3.09



        Rotation Projects

        Potential Rotation Projects

        Circadian clocks play an essential role in the temporal organization of animal physiology and behavior.Proper synchronization of these clocks with the day/night cycle is essential for their function. We combine the powerful genetics of Drosophila with molecular, cell culture and behavioral approaches to obtain a comprehensive view of the mechanisms regulating circadian rhythms and their synchronization.

        Rotation projects could for example focus on the mechanisms of signal transduction in the CRY light input pathway, on the molecular mechanisms underlying circadian temperature responses, or on characterizing the neural network controlling the synchronization of circadian behavior with light and temperature cycles.



        Bibliographic 
        selected publications
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        1. Zhang Y, Ling J, Yuan C, Dubruille R, Emery P. A Role for Drosophila ATX2 in Activation of PER Translation and Circadian Behavior. Science. 2013 May 17; 340(6134):879-882.
          View in: PubMed
        2. Zhang Y, Emery P. GW182 Controls Drosophila Circadian Behavior and PDF-Receptor Signaling. Neuron. 2013 Apr 10; 78(1):152-65.
          View in: PubMed
        3. Karpowicz P, Zhang Y, Hogenesch JB, Emery P, Perrimon N. The Circadian Clock Gates the Intestinal Stem Cell Regenerative State. Cell Rep. 2013 Apr 10.
          View in: PubMed
        4. Ling J, Dubruille R, Emery P. KAYAK-a Modulates Circadian Transcriptional Feedback Loops in Drosophila Pacemaker Neurons. J Neurosci. 2012 Nov 21; 32(47):16959-70.
          View in: PubMed
        5. Emery P. Circadian rhythms: an electric jolt to the clock. Curr Biol. 2012 Oct 23; 22(20):R876-8.
          View in: PubMed
        6. Kaneko H, Head LM, Ling J, Tang X, Liu Y, Hardin PE, Emery P, Hamada FN. Circadian Rhythm of Temperature Preference and Its Neural Control in Drosophila. Curr Biol. 2012 Sep 11.
          View in: PubMed
        7. Zhang Y, Liu Y, Bilodeau-Wentworth D, Hardin PE, Emery P. Light and temperature control the contribution of specific DN1 neurons to Drosophila circadian behavior. Curr Biol. 2010 Apr 13; 20(7):600-5.
          View in: PubMed
        8. Dubruille R, Murad A, Rosbash M, Emery P. A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. PLoS Genet. 2009 Dec; 5(12):e1000787.
          View in: PubMed
        9. Dubruille R, Emery P. A plastic clock: how circadian rhythms respond to environmental cues in Drosophila. Mol Neurobiol. 2008 Oct; 38(2):129-45.
          View in: PubMed
        10. Zhu H, Sauman I, Yuan Q, Casselman A, Emery-Le M, Emery P, Reppert SM. Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation. PLoS Biol. 2008 Jan; 6(1):e4.
          View in: PubMed
        11. Busza A, Murad A, Emery P. Interactions between circadian neurons control temperature synchronization of Drosophila behavior. J Neurosci. 2007 Oct 3; 27(40):10722-33.
          View in: PubMed
        12. Emery P, Freeman MR. Glia got rhythm. Neuron. 2007 Aug 2; 55(3):337-9.
          View in: PubMed
        13. Kaushik R, Nawathean P, Busza A, Murad A, Emery P, Rosbash M. PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. PLoS Biol. 2007 Jun; 5(6):e146.
          View in: PubMed
        14. Murad A, Emery-Le M, Emery P. A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila. Neuron. 2007 Mar 1; 53(5):689-701.
          View in: PubMed
        15. Rush BL, Murad A, Emery P, Giebultowicz JM. Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary. J Biol Rhythms. 2006 Aug; 21(4):272-8.
          View in: PubMed
        16. Emery P, Reppert SM. A rhythmic Ror. Neuron. 2004 Aug 19; 43(4):443-6.
          View in: PubMed
        17. Martin G, Puig S, Pietrzykowski A, Zadek P, Emery P, Treistman S. Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens. J Neurosci. 2004 Jul 21; 24(29):6563-72.
          View in: PubMed
        18. Busza A, Emery-Le M, Rosbash M, Emery P. Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science. 2004 Jun 4; 304(5676):1503-6.
          View in: PubMed
        19. Zhao J, Kilman VL, Keegan KP, Peng Y, Emery P, Rosbash M, Allada R. Drosophila clock can generate ectopic circadian clocks. Cell. 2003 Jun 13; 113(6):755-66.
          View in: PubMed
        20. McDonald MJ, Rosbash M, Emery P. Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter. Mol Cell Biol. 2001 Feb; 21(4):1207-17.
          View in: PubMed
        21. Allada R, Emery P, Takahashi JS, Rosbash M. Stopping time: the genetics of fly and mouse circadian clocks. Annu Rev Neurosci. 2001; 24:1091-119.
          View in: PubMed
        22. Emery P, Stanewsky R, Helfrich-Förster C, Emery-Le M, Hall JC, Rosbash M. Drosophila CRY is a deep brain circadian photoreceptor. Neuron. 2000 May; 26(2):493-504.
          View in: PubMed
        23. Emery P, Stanewsky R, Hall JC, Rosbash M. A unique circadian-rhythm photoreceptor. Nature. 2000 Mar 30; 404(6777):456-7.
          View in: PubMed
        24. Emery P, So WV, Kaneko M, Hall JC, Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell. 1998 Nov 25; 95(5):669-79.
          View in: PubMed
        25. Stanewsky R, Kaneko M, Emery P, Beretta B, Wager-Smith K, Kay SA, Rosbash M, Hall JC. The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell. 1998 Nov 25; 95(5):681-92.
          View in: PubMed
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