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Yang Xiang PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentNeurobiology
AddressUMass Chan Medical School
366 Plantation Street, NERB
Worcester MA 01605
Phone508-856-6148
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurobiology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Nanjing University, Nanjing, , ChinaBSBiochemistry
    Chinese Academy of Sciences, Beijing, , ChinaPHDNeurobiology

    Collapse Overview 
    Collapse overview


    Biography



    Yang Xiang received his B.S. in Biochemistry from Nanjing University in 1999. He carried out his doctoral training in the laboratory of Dr. Mu-ming Poo at the institute of Neuroscience, Chinese Academy of Sciences, where he studied axonal guidance, obtained his Ph.D in Neurobiology in 2003. Yang Xiang then received the Human Frontiers Science Program fellowship to work as a postdoctoral associate with Dr. Yuh-Nung Jan at HHMI, University of California San Francisco from 2004-2012, studying sensory neuron function in Drosophila. He started his laboratory in the Department of Neurobiology at The University of Massachusetts Medical School in 2012.



    Molecular and neural circuit mechanisms underlying behavior



    Our lab is interested in understanding how the nervous system detects and processes sensory stimuli to generate appropriate behavior, a central question in neurobiology. We work on the genetically tractable organism Drosophila. Specifically, our research focuses on the innate escape behavior triggered by harmful light in Drosophila larvae. We found that a specific class of sensory neurons (namely, class IV dendritic arborization (da) neurons) are novel photoreceptors activated by intense harmful short wavelength light, with spectral sensitivity UV>violet>blue>>green~red, and mediate larval escape behavior when illuminated by UV, violet and blue light. Classical phototransduction molecules are not required in class IV da neurons. Instead, gustatory receptor 28b (Gr28b), G protein signaling and dTRPA1 are critical. Beyond harmful light, class IV da neurons also sense noxious heat (>40oC) and the irritant chemical AITC, a major component of wasabi.



    Applying molecular genetics, GCaMP-based functional imaging, electrophysiology, and behavioral assay, our goal is to dissect the molecular, cellular and neural circuit mechanisms underlying sensory stimuli-induced behavior in Drosophila larvae. Specifically, we aim to (1) identify the phototransduction mechanism in class IV da neurons; (2) define and characterize the neural circuits underlying light-induced escape behavior. 



    People in the lab







































































    Postdoctoral Fellows


     




    Pengyu Gu, Ph.D.(Nanjing University)

     

     


    Student


    Tackle

    Kendra Takle, B.S.(University of Wisconsin, Madison)

     





    Yang Xiang photo 1


     



    Figure 1 Dorsal view of a 3rd instar Drosophila larva (5 mm in length) with class IV da neurons marked by ppk-CD4TdGFP. en-GAL4 in red marks the posterior epidermal cells of each segment. Each larva has 11 segments and there are 3 class IV da neurons in each hemi-segment. Dendrites of class IV da neurons cover the entire larval body wall in a complete but non-overlapping fashion, a phenomenon called dendritic tiling. This organization will ensure that larvae can detect strong harmful light exposure over their entire bodies. (Image Credit: Dr. Chun Han, UCSF)

     

     


    Yang Xiang photo 2



     



    Figure 2 class IV da neurons detect harmful UV to initiate the escape behavior. Our working model is that Gr28b absorbs photon, and leads to dTRPA1 channels opening and action potential firing in class IV da neurons. Electrical signals encoded by class IV da neurons will be decoded by neural circuits in the CNS into escape behavior.

     

     



    Get Flash player.




     





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    Movie 1 Upon 5 s light stimulation of the anterior region (0.57 mW/mm2 white light, comparable to sunlight intensity), a 3rd instar larva of wt (left) exhibits avoidance behavior, while a larva with class IV da neurons genetically ablated (right) doesn’t avoid light.

     


    Get Flash player.



    Movie 2 Class IV da neurons are specifically activated by UV (365 nm) and blue (470 nm), but not green (546 nm) light. Shown here are larval peripheral sensory neurons in a dorsal cluster expressing GCaMP3, with the arrow pointing to the class IV da neuron. 5 s light stimulation is indicated in the upper-right corner. GCaMP3 fluorescence is marked by pseudo-color, with red indicating high and blue indicating low intensity. Similar light activation of class IV da neurons is observed in lateral and ventral clusters across the entire larval body wall.

     

     


     



     


     



     


     

    Collapse Rotation Projects

    One rotation student is expected in the lab to characterize the expression and function of Drosophila gustatory receptor 28b (Gr28b) in phototransduction and taste sensation. Please contact Dr. Yang Xiang for details.

     

    Yang Xiang, Ph.D.
    University of Massachusetts Medical School
    Department of Neurobiology, LRB 725
    364 Plantation Street
    Worcester, MA 01605 USA
    phone: 508-856-6816 (office)
    e-mail:
    yang.xiang@umassmed.edu



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Guo SS, Li XY, Liu LT, Jia GD, Liu SL, Sun XS, Luo DH, Yang JH, Xie SY, Li YF, Lv X, Xiang YQ, Xia WX, Sun R, Liu Q, Li JB, Wang P, Yang Q, Wang L, Wen DX, Jin J, Lin JY, Mo HY, Guo L, Zhao C, Guo X, Chen QY, Tang LQ, Mai HQ. Induction vs Adjuvant Chemoradiotherapy in Patients With High-Risk N2 to N3 Nasopharyngeal Carcinoma: A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2025 Aug 01; 11(8):864-873. PMID: 40531520.
      Citations:    
    2. He SQ, Liu GY, Yu YH, Wang L, Zhang GY, Peng DS, Bei WX, Chen CL, Lv SH, Zhao ZY, Huang Y, Xiang YQ. Efficacy of local-regional radiotherapy in de novo metastatic nasopharyngeal carcinoma patients receiving chemo-immunotherapy: A multicenter, propensity score matching study. Radiother Oncol. 2025 Feb; 203:110687. PMID: 39709030.
      Citations:    
    3. Wang WX, Wu YS, Qi LP, Wu AMS, Zhu YY, Gong WJ, Guo SS, Hua YJ, Luo DH, Chen QY, Xiang YQ, Zhang JX, Mai HQ, Li JB. Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer. Front Public Health. 2024; 12:1469001. PMID: 39697293.
      Citations:    
    4. He SQ, Liu GY, Yu YH, Wang L, Zhang GY, Peng DS, Bei WX, Chen CL, Lv SH, Zhao ZY, Huang Y, Xiang YQ. Establishing M1 subdivision for de novo nasopharyngeal carcinoma patients receiving immuno-chemotherapy: A multicenter, retrospective cohort study. Oral Oncol. 2024 Dec; 159:107074. PMID: 39393309.
      Citations:    
    5. Liu GY, Ye YF, Jiang YF, Chen GJ, Xia WX, Huang YS, Gao TS, Liu YM, Hou YT, Li JF, Liu JH, Lu N, Chen CL, Ke LR, Liang H, Bei WX, Li WZ, Dong SH, Liu Q, Xie C, Yao HR, Xiang YQ. Nab-paclitaxel, cisplatin, and capecitabine versus cisplatin and gemcitabine as first line chemotherapy in patients with recurrent or metastatic nasopharyngeal carcinoma: randomised phase 3 clinical trial. BMJ. 2024 06 19; 385:e077890. PMID: 38897625.
      Citations:    
    6. Liang H, Jiang YF, Liu GY, Wang L, Wang JW, Lu N, Xia WX, Ke LR, Ye YF, Duan JL, Bei WX, Dong SH, Li WZ, Liu LT, Zhao C, Xie C, Xiang YQ. Camrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial. Nat Commun. 2024 Feb 03; 15(1):1029. PMID: 38310101.
      Citations:    
    7. Lu N, Jiang YF, Xia WX, Huang Y, Xie CM, Xu C, Ye YF, Liu GY, Bei WX, Ke LR, Li WZ, Zhang C, Wang X, Liu Q, Chen X, Chen ZX, Xie C, Liang H, Xiang YQ. Efficacy and safety of sintilimab plus bevacizumab in metastatic nasopharyngeal carcinoma after failure of platinum-based chemotherapy: an open-label phase 2 study. EClinicalMedicine. 2023 Aug; 62:102136. PMID: 37593221.
      Citations:    
    8. Gong J, Nirala NK, Chen J, Wang F, Gu P, Wen Q, Ip YT, Xiang Y. TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila. Sci Adv. 2023 05 24; 9(21):eadc9660. PMID: 37224252.
      Citations: 2     Fields:    Translation:AnimalsCells
    9. Wang F, Ruppell KT, Zhou S, Qu Y, Gong J, Shang Y, Wu J, Liu X, Diao W, Li Y, Xiang Y. Gliotransmission and adenosine signaling promote axon regeneration. Dev Cell. 2023 04 24; 58(8):660-676.e7. PMID: 37028426.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Chen J, Jiang C, Fu L, Zhu CL, Xiang YQ, Jiang LX, Chen Q, Liu WM, Chen JN, Zhang LY, Liu M, Chen C, Tang H, Wang B, Tsao SW, Kwong DL, Guan XY. Erratum: CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin ?1 and Merlin: Erratum. Int J Biol Sci. 2023; 19(3):829-830. PMID: 36778119.
      Citations:    
    11. Miao J, Wang L, Tan SH, Li JG, Yi J, Ong EHW, Tan LLY, Zhang Y, Gong X, Chen Q, Xiang YQ, Chen MY, Guo Y, Lv X, Xia WX, Tang L, Deng X, Guo X, Han F, Mai HQ, Chua MLK, Zhao C. Adjuvant Capecitabine Following Concurrent Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma: A Randomized Clinical Trial. JAMA Oncol. 2022 Oct 13. PMID: 36227615.
      Citations:    
    12. Gong J, Chen J, Gu P, Shang Y, Ruppell KT, Yang Y, Wang F, Wen Q, Xiang Y. Shear stress activates nociceptors to drive Drosophila mechanical nociception. Neuron. 2022 11 16; 110(22):3727-3742.e8. PMID: 36087585.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Liu GY, Xia WX, Bi ZF, Lu N, Li WZ, Bei WX, Liang H, Xie JZ, Liu YM, Yao HR, Xiang YQ. Plasma Circulating Tumor Epstein-Barr Virus for the Surveillance of Cancer Progression in Bone-Only Metastatic Nasopharyngeal Carcinoma. Front Oncol. 2022; 12:860700. PMID: 35756638.
      Citations:    
    14. Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX. Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial. JAMA Oncol. 2022 05 01; 8(5):706-714. PMID: 35323856.
      Citations:    
    15. Liu GY, Li WZ, Wang DS, Liang H, Lv X, Ye YF, Zhao C, Ke LR, Lv SH, Lu N, Bei WX, Cai ZC, Chen X, Liang CX, Guo X, Xia WX, Xiang YQ. Effect of Capecitabine Maintenance Therapy Plus Best Supportive Care vs Best Supportive Care Alone on Progression-Free Survival Among Patients With Newly Diagnosed Metastatic Nasopharyngeal Carcinoma Who Had Received Induction Chemotherapy: A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2022 04 01; 8(4):553-561. PMID: 35175316.
      Citations:    
    16. Gu P, Wang F, Shang Y, Liu J, Gong J, Xie W, Han J, Xiang Y. Nociception and hypersensitivity involve distinct neurons and molecular transducers in Drosophila. Proc Natl Acad Sci U S A. 2022 03 22; 119(12):e2113645119. PMID: 35294287.
      Citations: 6     Fields:    Translation:AnimalsCells
    17. Xia WX, Lv X, Liang H, Liu GY, Sun R, Zeng Q, Li SW, Mo HY, Han F, Luo DH, Liu Q, Shi MY, Ye YF, Yang J, Ke LR, Qiang MY, Qiu WZ, Yu YH, Liu KY, Huang XJ, Li WZ, Lv SH, Cai ZC, Miao JJ, Guo L, Chen MY, Cao KJ, Wang L, Zhao C, Huang PY, Chen QY, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ. A Randomized Controlled Trial Comparing Two Different Schedules for Cisplatin Treatment in Patients with Locoregionally Advanced Nasopharyngeal Cancer. Clin Cancer Res. 2021 08 01; 27(15):4186-4194. PMID: 34083231.
      Citations:    
    18. Lv X, Cao X, Xia WX, Liu KY, Qiang MY, Guo L, Qian CN, Cao KJ, Mo HY, Li XM, Li ZH, Han F, He YX, Liu YM, Wu SX, Bai YR, Ke LR, Qiu WZ, Liang H, Liu GY, Miao JJ, Li WZ, Lv SH, Chen X, Zhao C, Xiang YQ, Guo X. Induction chemotherapy with lobaplatin and fluorouracil versus cisplatin and fluorouracil followed by chemoradiotherapy in patients with stage III-IVB nasopharyngeal carcinoma: an open-label, non-inferiority, randomised, controlled, phase 3 trial. Lancet Oncol. 2021 05; 22(5):716-726. PMID: 33857411.
      Citations:    
    19. Xiang ZF, Hu DF, Xiong HC, Li MY, Zhang ZC, Shen ED, Li WZ, Xiang YQ. Benefit of chemotherapy in stage III nasopharyngeal carcinoma: Analysis of the surveillance, epidemiology, and end results database. Oral Oncol. 2021 06; 117:105284. PMID: 33845238.
      Citations:    
    20. Li WZ, Lv SH, Liu GY, Liang H, Guo X, Lv X, Liu KY, Qiang MY, Chen X, Gu SZ, Xie CQ, Xia WX, Xiang YQ. Development of a Prognostic Model to Identify the Suitable Definitive Radiation Therapy Candidates in de Novo Metastatic Nasopharyngeal Carcinoma: A Real-World Study. Int J Radiat Oncol Biol Phys. 2021 01 01; 109(1):120-130. PMID: 32853711.
      Citations:    
    21. Jiang C, Li L, Xiang YQ, Lung ML, Zeng T, Lu J, Tsao SW, Zeng MS, Yun JP, Kwong DLW, Guan XY. Epstein-Barr Virus miRNA BART2-5p Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing RND3. Cancer Res. 2020 05 15; 80(10):1957-1969. PMID: 32060148.
      Citations:    
    22. Li WZ, Liu GY, Lin LF, Lv SH, Qiang MY, Lv X, Wu YS, Liang H, Ke LR, Wang DL, Yu YH, Qiu WZ, Liu KY, Guo X, Li JP, Zou YJ, Xiang YQ, Xia WX. MRI-detected residual retropharyngeal lymph node after intensity-modulated radiotherapy in nasopharyngeal carcinoma: Prognostic value and a nomogram for the pretherapy prediction of it. Radiother Oncol. 2020 04; 145:101-108. PMID: 31931288.
      Citations:    
    23. Gu P, Gong J, Shang Y, Wang F, Ruppell KT, Ma Z, Sheehan AE, Freeman MR, Xiang Y. Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Curr Biol. 2019 12 02; 29(23):3961-3973.e6. PMID: 31735672.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Yang Q, Cao SM, Guo L, Hua YJ, Huang PY, Zhang XL, Lin M, You R, Zou X, Liu YP, Xie YL, Wang ZQ, Mai HQ, Chen QY, Tang LQ, Mo HY, Cao KJ, Qian CN, Zhao C, Xiang YQ, Zhang XP, Lin ZX, Li WX, Liu Q, Li JB, Ling L, Guo X, Hong MH, Chen MY. Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: long-term results of a phase III multicentre randomised controlled trial. Eur J Cancer. 2019 09; 119:87-96. PMID: 31425966.
      Citations:    
    25. Chen J, Jiang C, Fu L, Zhu CL, Xiang YQ, Jiang LX, Chen Q, Liu WM, Chen JN, Zhang LY, Liu M, Chen C, Tang H, Wang B, Tsao SW, Kwong DL, Guan XY. CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin ?1 and Merlin. Int J Biol Sci. 2019; 15(9):1802-1815. PMID: 31523184.
      Citations:    
    26. Yang Q, Zhao TT, Qiang MY, Hu L, Lv X, Ye YF, Ke LR, Yu YH, Qiu WZ, Liu GY, Huang XJ, Li WZ, Lv SH, Sun Y, Zhang LY, Pei F, Guo X, Xiang YQ, Qian CN, Huang BJ, Xia WX. Concurrent Chemoradiotherapy versus Intensity-modulated Radiotherapy Alone for Elderly Nasopharyngeal Carcinoma Patients with Pre-treatment Epstein-Barr Virus DNA: A Cohort Study in an Endemic Area with Long-term Follow-up. J Cancer. 2018; 9(17):3023-3031. PMID: 30210624.
      Citations:    
    27. Liang H, Lv X, Wang L, Wu YS, Sun R, Ye YF, Ke LR, Yang Q, Yu YH, Qiu WZ, Liu GY, Huang XJ, Li WZ, Lv SH, Guo X, Xiang YQ, Xia WX. The plasma Epstein-Barr virus DNA level guides precision treatment for nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: a large population-based cohort study from an endemic area. Ther Adv Med Oncol. 2018; 10:1758835918782331. PMID: 30046357.
      Citations:    
    28. Liu GY, Lv X, Wu YS, Mao MJ, Ye YF, Yu YH, Liang H, Yang J, Ke LR, Qiu WZ, Huang XJ, Li WZ, Guo X, Xiang YQ, Xia WX. Effect of induction chemotherapy with cisplatin, fluorouracil, with or without taxane on locoregionally advanced nasopharyngeal carcinoma: a retrospective, propensity score-matched analysis. Cancer Commun (Lond). 2018 05 10; 38(1):21. PMID: 29764487.
      Citations:    
    29. Qiu WZ, Zhang HB, Xia WX, Ke LR, Yang J, Yu YH, Liang H, Huang XJ, Liu GY, Li WZ, Xiang YQ, Kang TB, Guo X, Lv X. The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3?/snail signalling. J Exp Clin Cancer Res. 2018 Apr 17; 37(1):85. PMID: 29665837.
      Citations:    
    30. Tang LQ, Chen DP, Guo L, Mo HY, Huang Y, Guo SS, Qi B, Tang QN, Wang P, Li XY, Li JB, Liu Q, Gao YH, Xie FY, Liu LT, Li Y, Liu SL, Xie HJ, Liang YJ, Sun XS, Yan JJ, Wu YS, Luo DH, Huang PY, Xiang YQ, Sun R, Chen MY, Lv X, Wang L, Xia WX, Zhao C, Cao KJ, Qian CN, Guo X, Hong MH, Nie ZQ, Chen QY, Mai HQ. Concurrent chemoradiotherapy with nedaplatin versus cisplatin in stage II-IVB nasopharyngeal carcinoma: an open-label, non-inferiority, randomised phase 3 trial. Lancet Oncol. 2018 04; 19(4):461-473. PMID: 29501366.
      Citations:    
    31. Qiu WZ, Ke LR, Xia WX, Yang J, Yu YH, Liang H, Huang XJ, Liu GY, Li WZ, Xiang YQ, Guo X, Lv X. A retrospective study of 606 cases of nasopharyngeal carcinoma with or without oropharyngeal candidiasis during radiotherapy. PLoS One. 2017; 12(8):e0182963. PMID: 28797119.
      Citations:    
    32. Xie P, Yang JP, Cao Y, Peng LX, Zheng LS, Sun R, Meng DF, Wang MY, Mei Y, Qiang YY, Cao L, Xiang YQ, Luo DH, Yun JP, Huang BJ, Jia LJ, Qian CN. Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target. Cell Death Dis. 2017 06 01; 8(6):e2834. PMID: 28569775.
      Citations:    
    33. Cao SM, Yang Q, Guo L, Mai HQ, Mo HY, Cao KJ, Qian CN, Zhao C, Xiang YQ, Zhang XP, Lin ZX, Li WX, Liu Q, Qiu F, Sun R, Chen QY, Huang PY, Luo DH, Hua YJ, Wu YS, Lv X, Wang L, Xia WX, Tang LQ, Ye YF, Chen MY, Guo X, Hong MH. Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A phase III multicentre randomised controlled trial. Eur J Cancer. 2017 04; 75:14-23. PMID: 28214653.
      Citations:    
    34. Liang H, Xiang YQ, Lv X, Xie CQ, Cao SM, Wang L, Qian CN, Yang J, Ye YF, Gan F, Ke LR, Yu YH, Liu GY, Qiu WZ, Huang XJ, Wen CH, You N, Wang XQ, Guo X, Xia WX. Survival impact of waiting time for radical radiotherapy in nasopharyngeal carcinoma: A large institution-based cohort study from an endemic area. Eur J Cancer. 2017 03; 73:48-60. PMID: 28161498.
      Citations:    
    35. Tang LQ, Li CF, Li J, Chen WH, Chen QY, Yuan LX, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Zhang L, Guo SS, Liu LT, Guo L, Wu YS, Luo DH, Huang PY, Mo HY, Xiang YQ, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Cao KJ, Qian CN, Guo X, Zeng YX, Mai HQ, Zeng MS. Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma. J Natl Cancer Inst. 2016 Jan; 108(1). PMID: 26467665.
      Citations:    
    36. Guntur AR, Gu P, Takle K, Chen J, Xiang Y, Yang CH. Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):E5753-61. PMID: 26443856.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    37. Ye YF, Xiang YQ, Fang F, Gao R, Zhang LF, Xie SH, Liu Z, Du JL, Chen SH, Hong MH, Qian CN, Ye W, Zeng YX, Liu Q, Cao SM. Hepatitis B virus infection and risk of nasopharyngeal carcinoma in southern China. Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1766-73. PMID: 26364160.
      Citations:    
    38. Qin L, Yin YT, Zheng FJ, Peng LX, Yang CF, Bao YN, Liang YY, Li XJ, Xiang YQ, Sun R, Li AH, Zou RH, Pei XQ, Huang BJ, Kang TB, Liao DF, Zeng YX, Williams BO, Qian CN. WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis. Oncotarget. 2015 Apr 30; 6(12):10239-52. PMID: 25823923.
      Citations:    
    39. Yang L, Li R, Kaneko T, Takle K, Morikawa RK, Essex L, Wang X, Zhou J, Emoto K, Xiang Y, Ye B. Trim9 regulates activity-dependent fine-scale topography in Drosophila. Curr Biol. 2014 May 05; 24(9):1024-30. PMID: 24746793.
      Citations: 17     Fields:    Translation:AnimalsCells
    40. Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE, Meltzer S, Jan LY, Jan YN. Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature. 2013 Jan 10; 493(7431):221-5. PMID: 23222543.
      Citations: 153     Fields:    Translation:AnimalsCells
    41. Huang PY, Cao KJ, Guo X, Mo HY, Guo L, Xiang YQ, Deng MQ, Qiu F, Cao SM, Guo Y, Zhang L, Li NW, Sun R, Chen QY, Luo DH, Hua YJ, Mai HQ, Hong MH. A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Oral Oncol. 2012 Oct; 48(10):1038-1044. PMID: 22591726.
      Citations:    
    42. Yan, Z. *, Zhang, W. *, He, Y., Gorczyca, D., Xiang, Y., Cheng, L., Meltzer, S., Jan, L.Y., & Jan, Y.N. NompC is a pore-forming subunit of a mechanotransduction channel for sensing gentle touch in Drosophila. Nature. 2012; (In press).
    43. Yuan, Q., Xiang, Y., Yan, Z.Q., Han, C., Jan, L.Y., & Jan, Y.N. Light induced structural and functional plasticity in Drosophila larval visual System. Science. 2011; 333:1458-1462.
    44. Xiang, Y., Yuan, Q., Vogt, N., Looger, L. L., Jan, L. Y. and Jan, Y. N. Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature. 2010; 468:921-926. (research article).
    45. Yang, C., Rumpf, S., Xiang, Y., Gordon, M. D., Song, W., Scott, K., Jan, L. Y. and Jan, Y. N. . Control of post-mating behavior switch in Drosophila females by internal sensory neurons. Neuron. 2009; 61:519-526.
    46. Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X., Wu, C., Poo, M. and Duan, S. Nerve growth cone guidance mediated by G protein-coupled receptors. Nature Neuroscience. 2002; 5:843-848.
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