Sign in to edit your profile (add interests, mentoring, photo, etc.)
    Keywords
    Last Name
    Institution

    Eva Tsuda MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-3039
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research

        Overview 
        Narrative

        Academic Background

        MD, Semmelweis Medical School, Budapest, Hungary

        Dr. Eva Szomolanyi-Tsuda

        Interactions of viral gene products and host immune systems

        I have started my career in molecular virology, and worked on a variety of DNA tumor viruses. Later, in the 1990s I have changed the focus of my work, concentrating on viral immunology and pathogenesis. The main goal of my studies in a broad sense is to understand how viral gene products and components of the host immune system (innate and adaptive) interact and contribute to control virus infections, and virus-induced tumors. For many years I have been studying the immunological control of murine polyomavirus (PyV) in mice, a natural host-virus model. Our report on T cell-independent IgG responses to PyV was the first to show that a virus infection can generate protective IgG to antigens which are chemically proteins, in the absence of T cells. More recently, we published the important observation that MyD88-mediated pathways are required for long-term antibody responses to PyV, as MyD88 knock-out (KO) mice have decreased serum IgG responses, greatly reduced long-lived plasma cell population in the bone marrow, and diminished memory B cell responses compared to wild type mice. These data suggest an essential role for the MyD88-mediated pathways in the generation of long-term humoral immunity. Presently our efforts are aimed to elucidate the signals/pathways in B cells, follicular helper T cells (TFH) and accessory cells that are essential for the generation and maintenance of life- long humoral immunity and the molecular mechanisms involved in these processes.

        Rotation Projects

        Potential Rotation Projects Include

        • Characterization of innate receptor activation by PyV on various cell types
        • Determining what steps of B cell responses are affected in PyV-infected mice with MyD88 mutationn in B cells  or other cell types.
        • Testing signals (surface and soluble) that regulate TI IgG isotype switching in T cell-deficient PyV-infected mice
        • Testing the immunological basis of susceptibility to PyV-induced tumors: role of NK and gd T cells


        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Wigglesworth KM, Racki WJ, Mishra R, Szomolanyi-Tsuda E, Greiner DL, Galili U. Rapid Recruitment and Activation of Macrophages by Anti-Gal/{alpha}-Gal Liposome Interaction Accelerates Wound Healing. J Immunol. 2011 Apr 1; 186(7):4422-32.
          View in: PubMed
        2. Mishra R, Chen AT, Welsh RM, Szomolanyi-Tsuda E. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog. 2010 May; 6(5):e1000924.
          View in: PubMed
        3. Guikema JE, Schrader CE, Brodsky MH, Linehan EK, Richards A, El Falaky N, Li DH, Sluss HK, Szomolanyi-Tsuda E, Stavnezer J. p53 represses class switch recombination to IgG2a through its antioxidant function. J Immunol. 2010 Jun 1; 184(11):6177-87.
          View in: PubMed
        4. Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010 May; 11(5):395-402.
          View in: PubMed
        5. Guay HM, Mishra R, Garcea RL, Welsh RM, Szomolanyi-Tsuda E. Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells. J Immunol. 2009 Jul 1; 183(1):518-23.
          View in: PubMed
        6. Swanson PA, Lukacher AE, Szomolanyi-Tsuda E. Immunity to polyomavirus infection: the polyomavirus-mouse model. Semin Cancer Biol. 2009 Aug; 19(4):244-51.
          View in: PubMed
        7. Kemball CC, Szomolanyi-Tsuda E, Lukacher AE. Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation. J Virol. 2007 Dec; 81(24):13743-53.
          View in: PubMed
        8. Kemball CC, Pack CD, Guay HM, Li ZN, Steinhauer DA, Szomolanyi-Tsuda E, Lukacher AE. The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. J Immunol. 2007 Jul 15; 179(2):1113-21.
          View in: PubMed
        9. Guay HM, Andreyeva TA, Garcea RL, Welsh RM, Szomolanyi-Tsuda E. MyD88 is required for the formation of long-term humoral immunity to virus infection. J Immunol. 2007 Apr 15; 178(8):5124-31.
          View in: PubMed
        10. Jellison ER, Guay HM, Szomolanyi-Tsuda E, Welsh RM. Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen. Eur J Immunol. 2007 Jan; 37(1):119-28.
          View in: PubMed
        11. Szomolanyi-Tsuda E, Seedhom MO, Carroll MC, Garcea RL. T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient mice. Virology. 2006 Aug 15; 352(1):52-60.
          View in: PubMed
        12. Szomolanyi-Tsuda E, Liang X, Welsh RM, Kurt-Jones EA, Finberg RW. Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo. J Virol. 2006 May; 80(9):4286-91.
          View in: PubMed
        13. Kemball CC, Lee ED, Szomolanyi-Tsuda E, Pearson TC, Larsen CP, Lukacher AE. Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. J Immunol. 2006 Feb 1; 176(3):1814-24.
          View in: PubMed
        14. Szomolanyi-Tsuda E, Welsh RM. Judging a virus by its cover. J Clin Invest. 2004 Oct; 114(7):895-7.
          View in: PubMed
        15. Gavanescu I, Pihan G, Halilovic E, Szomolanyi-Tsuda E, Welsh RM, Doxsey S. Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice. Clin Exp Immunol. 2004 Aug; 137(2):288-97.
          View in: PubMed
        16. Welsh RM, Selin LK, Szomolanyi-Tsuda E. Immunological memory to viral infections. Annu Rev Immunol. 2004; 22:711-43.
          View in: PubMed
        17. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003 Apr 1; 170(7):3819-27.
          View in: PubMed
        18. Welsh RM, Stepp SE, Szomolanyi-Tsuda E. B cell memory: sapping the T cell. Nat Med. 2003 Feb; 9(2):164-6.
          View in: PubMed
        19. Welsh RM, Stepp SE, Szomolanyi-Tsuda E, Peacock CD. Tumor viral escape from inhibited T cells. Nat Immunol. 2002 Feb; 3(2):112-4.
          View in: PubMed
        20. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7.
          View in: PubMed
        21. Selin LK, Santolucito PA, Pinto AK, Szomolanyi-Tsuda E, Welsh RM. Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells. J Immunol. 2001 Jun 1; 166(11):6784-94.
          View in: PubMed
        22. Szomolanyi-Tsuda E, Brien JD, Dorgan JE, Garcea RL, Woodland RT, Welsh RM. Antiviral T-cell-independent type 2 antibody responses induced in vivo in the absence of T and NK cells. Virology. 2001 Feb 15; 280(2):160-8.
          View in: PubMed
        23. Szomolanyi-Tsuda E, Brien JD, Dorgan JE, Welsh RM, Garcea RL. The role of CD40-CD154 interaction in antiviral T cell-independent IgG responses. J Immunol. 2000 Jun 1; 164(11):5877-82.
          View in: PubMed
        24. Szomolanyi-Tsuda E, Le QP, Garcea RL, Welsh RM. T-Cell-independent immunoglobulin G responses in vivo are elicited by live-virus infection but not by immunization with viral proteins or virus-like particles. J Virol. 1998 Aug; 72(8):6665-70.
          View in: PubMed
        25. Szomolanyi-Tsuda E, Welsh RM. T-cell-independent antiviral antibody responses. Curr Opin Immunol. 1998 Aug; 10(4):431-5.
          View in: PubMed
        26. Tay CH, Szomolanyi-Tsuda E, Welsh RM. Control of infections by NK cells. Curr Top Microbiol Immunol. 1998; 230:193-220.
          View in: PubMed
        27. Szomolanyi-Tsuda E, Welsh RM. T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice. J Exp Med. 1996 Feb 1; 183(2):403-11.
          View in: PubMed
        28. Szomolanyi-Tsuda E, Dundon PL, Joris I, Shultz LD, Woda BA, Welsh RM. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice. Am J Pathol. 1994 Feb; 144(2):359-71.
          View in: PubMed
        For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
        Eva's Networks
        Click the "See All" links for more information and interactive visualizations!
        Concepts
        _
        Co-Authors
        _
        Similar People
        _
        Same Department
        Physical Neighbors
        _

        This is an official Page/Publication of the University of Massachusetts Worcester Campus
        Office of the Vice Provost for Research, 55 Lake Ave North, Worcester, Massachusetts 01655
        Questions or Comments? Email: publicaffairs@umassmed.edu Phone: 508-856-1572