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    Last Name

    Eva Tsuda MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for AIDS Research


        Academic Background

        MD, Semmelweis Medical School, Budapest, Hungary

        Dr. Eva Szomolanyi-Tsuda

        Interactions of viral gene products and host immune systems

        I have started my career in molecular virology, and worked on a variety of DNA tumor viruses. Later, in the 1990s I have changed the focus of my work, concentrating on viral immunology and pathogenesis. The main goal of my studies in a broad sense is to understand how viral gene products and components of the host immune system (innate and adaptive) interact and contribute to control virus infections, and virus-induced tumors. For many years I have been studying the immunological control of murine polyomavirus (PyV) in mice, a natural host-virus model. Our report on T cell-independent IgG responses to PyV was the first to show that a virus infection can generate protective IgG to antigens which are chemically proteins, in the absence of T cells. More recently, we published the important observation that MyD88-mediated pathways are required for long-term antibody responses to PyV, as MyD88 knock-out (KO) mice have decreased serum IgG responses, greatly reduced long-lived plasma cell population in the bone marrow, and diminished memory B cell responses compared to wild type mice. These data suggest an essential role for the MyD88-mediated pathways in the generation of long-term humoral immunity. Presently our efforts are aimed to elucidate the signals/pathways in B cells, follicular helper T cells (TFH) and accessory cells that are essential for the generation and maintenance of life- long humoral immunity and the molecular mechanisms involved in these processes.

        Rotation Projects

        Potential Rotation Projects Include

        • Characterization of innate receptor activation by PyV on various cell types
        • Determining what steps of B cell responses are affected in PyV-infected mice with MyD88 mutationn in B cells  or other cell types.
        • Testing signals (surface and soluble) that regulate TI IgG isotype switching in T cell-deficient PyV-infected mice
        • Testing the immunological basis of susceptibility to PyV-induced tumors: role of NK and gd T cells

        selected publications
        List All   |   Timeline
        1. Wigglesworth KM, Racki WJ, Mishra R, Szomolanyi-Tsuda E, Greiner DL, Galili U. Rapid recruitment and activation of macrophages by anti-Gal/a-Gal liposome interaction accelerates wound healing. J Immunol. 2011 Apr 1; 186(7):4422-32.
          View in: PubMed
        2. Mishra R, Chen AT, Welsh RM, Szomolanyi-Tsuda E. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog. 2010 May; 6(5):e1000924.
          View in: PubMed
        3. Guikema JE, Schrader CE, Brodsky MH, Linehan EK, Richards A, El Falaky N, Li DH, Sluss HK, Szomolanyi-Tsuda E, Stavnezer J. p53 represses class switch recombination to IgG2a through its antioxidant function. J Immunol. 2010 Jun 1; 184(11):6177-87.
          View in: PubMed
        4. Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010 May; 11(5):395-402.
          View in: PubMed
        5. Guay HM, Mishra R, Garcea RL, Welsh RM, Szomolanyi-Tsuda E. Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells. J Immunol. 2009 Jul 1; 183(1):518-23.
          View in: PubMed
        6. Swanson PA, Lukacher AE, Szomolanyi-Tsuda E. Immunity to polyomavirus infection: the polyomavirus-mouse model. Semin Cancer Biol. 2009 Aug; 19(4):244-51.
          View in: PubMed
        7. Kemball CC, Szomolanyi-Tsuda E, Lukacher AE. Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation. J Virol. 2007 Dec; 81(24):13743-53.
          View in: PubMed
        8. Kemball CC, Pack CD, Guay HM, Li ZN, Steinhauer DA, Szomolanyi-Tsuda E, Lukacher AE. The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. J Immunol. 2007 Jul 15; 179(2):1113-21.
          View in: PubMed
        9. Guay HM, Andreyeva TA, Garcea RL, Welsh RM, Szomolanyi-Tsuda E. MyD88 is required for the formation of long-term humoral immunity to virus infection. J Immunol. 2007 Apr 15; 178(8):5124-31.
          View in: PubMed
        10. Jellison ER, Guay HM, Szomolanyi-Tsuda E, Welsh RM. Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen. Eur J Immunol. 2007 Jan; 37(1):119-28.
          View in: PubMed
        11. Kemball CC, Lee ED, Szomolanyi-Tsuda E, Pearson TC, Larsen CP, Lukacher AE. Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. J Immunol. 2006 Feb 1; 176(3):1814-24.
          View in: PubMed
        12. Szomolanyi-Tsuda E, Welsh RM. Judging a virus by its cover. J Clin Invest. 2004 Oct; 114(7):895-7.
          View in: PubMed
        13. Gavanescu I, Pihan G, Halilovic E, Szomolanyi-Tsuda E, Welsh RM, Doxsey S. Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice. Clin Exp Immunol. 2004 Aug; 137(2):288-97.
          View in: PubMed
        14. Welsh RM, Selin LK, Szomolanyi-Tsuda E. Immunological memory to viral infections. Annu Rev Immunol. 2004; 22:711-43.
          View in: PubMed
        15. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003 Apr 1; 170(7):3819-27.
          View in: PubMed
        16. Welsh RM, Stepp SE, Szomolanyi-Tsuda E. B cell memory: sapping the T cell. Nat Med. 2003 Feb; 9(2):164-6.
          View in: PubMed
        17. Welsh RM, Stepp SE, Szomolanyi-Tsuda E, Peacock CD. Tumor viral escape from inhibited T cells. Nat Immunol. 2002 Feb; 3(2):112-4.
          View in: PubMed
        18. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7.
          View in: PubMed
        19. Selin LK, Santolucito PA, Pinto AK, Szomolanyi-Tsuda E, Welsh RM. Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells. J Immunol. 2001 Jun 1; 166(11):6784-94.
          View in: PubMed
        20. Szomolanyi-Tsuda E, Welsh RM. T-cell-independent antiviral antibody responses. Curr Opin Immunol. 1998 Aug; 10(4):431-5.
          View in: PubMed
        21. Szomolanyi-Tsuda E, Le QP, Garcea RL, Welsh RM. T-Cell-independent immunoglobulin G responses in vivo are elicited by live-virus infection but not by immunization with viral proteins or virus-like particles. J Virol. 1998 Aug; 72(8):6665-70.
          View in: PubMed
        22. Tay CH, Szomolanyi-Tsuda E, Welsh RM. Control of infections by NK cells. Curr Top Microbiol Immunol. 1998; 230:193-220.
          View in: PubMed
        23. Szomolanyi-Tsuda E, Welsh RM. T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice. J Exp Med. 1996 Feb 1; 183(2):403-11.
          View in: PubMed
        24. Szomolanyi-Tsuda E, Dundon PL, Joris I, Shultz LD, Woda BA, Welsh RM. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice. Am J Pathol. 1994 Feb; 144(2):359-71.
          View in: PubMed
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