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Shinya Watanabe PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street
Worcester MA 01605
Phone508-856-5876
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine


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    Postdoc position is available. Please contact us.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brothwell MJ, Cao G, Maschek JA, Poss AM, Peterlin AD, Wang L, Baker TB, Shahtout JL, Siripoksup P, Pearce QJ, Johnson JM, Finger FM, Prola A, Pellizzari SA, Hale GL, Manuel AM, Watanabe S, Miranda ER, Affolter KE, Tippetts TS, Nikolova LS, Choi RH, Decker ST, Patil M, Catrow JL, Holland WL, Nowinski SM, Lark DS, Fisher-Wellman KH, Mimche PN, Evason KJ, Cox JE, Summers SA, Gerhart-Hines Z, Funai K. Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis. bioRxiv. 2025 Mar 27. PMID: 39416056.
      Citations:    
    2. Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K. Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. J Clin Invest. 2024 Apr 23; 134(11). PMID: 38652544.
      Citations:    
    3. Sokolova V, Lee G, Mullins A, Mody P, Watanabe S, Tan D. DNA-translocation-independent role of INO80 remodeler in DNA damage repairs. J Biol Chem. 2023 10; 299(10):105245. PMID: 37696438.
      Citations:    Fields:    Translation:AnimalsCells
    4. Hayashi Y, Nakayama J, Yamamoto M, Maekawa M, Watanabe S, Higashiyama S, Inoue JI, Yamamoto Y, Semba K. Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer. Cancer Cell Int. 2023 Apr 01; 23(1):57. PMID: 37005661.
      Citations:    
    5. Azuma K, Sakamoto M, Katayama S, Matsui A, Nakamichi K, Goshima N, Watanabe S, Nakayama J, Semba K. HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells. Genes Cells. 2023 Apr; 28(4):277-287. PMID: 36659836.
      Citations:    
    6. Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience. 2021 Jun 25; 24(6):102688. PMID: 34195566.
      Citations:    
    7. Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner KP, Korber P. Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nat Commun. 2021 05 28; 12(1):3232. PMID: 34050140.
      Citations: 19     Fields:    Translation:AnimalsCells
    8. Singh RK, Fan J, Gioacchini N, Watanabe S, Bilsel O, Peterson CL. Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange. Cell Rep. 2019 04 09; 27(2):374-386.e4. PMID: 30970243.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    9. Azmi IF, Watanabe S, Maloney MF, Kang S, Belsky JA, MacAlpine DM, Peterson CL, Bell SP. Nucleosomes influence multiple steps during replication initiation. Elife. 2017 03 21; 6. PMID: 28322723.
      Citations: 35     Fields:    Translation:AnimalsCells
    10. Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T. Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. Int J Mol Sci. 2017 Mar 14; 18(3). PMID: 28335437.
      Citations:    
    11. Echtenkamp FJ, Gvozdenov Z, Adkins NL, Zhang Y, Lynch-Day M, Watanabe S, Peterson CL, Freeman BC. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler. Mol Cell. 2016 12 01; 64(5):888-899. PMID: 27818141.
      Citations: 26     Fields:    Translation:AnimalsCells
    12. Krietenstein N, Wal M, Watanabe S, Park B, Peterson CL, Pugh BF, Korber P. Genomic Nucleosome Organization Reconstituted with Pure Proteins. Cell. 2016 Oct 20; 167(3):709-721.e12. PMID: 27768892.
      Citations: 117     Fields:    Translation:AnimalsCells
    13. Watanabe S, Peterson CL. Response to Comment on "A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme". Science. 2016 Jul 22; 353(6297):358. PMID: 27463666.
      Citations: 7     Fields:    Translation:AnimalsCells
    14. Watanabe S, Tan D, Lakshminarasimhan M, Washburn MP, Hong EJ, Walz T, Peterson CL. Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C. Nat Commun. 2015 May 12; 6:7108. PMID: 25964121.
      Citations: 44     Fields:    Translation:AnimalsCells
    15. Jeronimo C, Watanabe S, Kaplan CD, Peterson CL, Robert F. The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. Mol Cell. 2015 Jun 18; 58(6):1113-23. PMID: 25959393.
      Citations: 65     Fields:    Translation:AnimalsCells
    16. Watanabe S, Peterson CL. Chromatin dynamics: flipping the switch on a chromatin remodeling machine. Cell Cycle. 2013 Aug 01; 12(15):2337-8. PMID: 23856580.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Watanabe S, Radman-Livaja M, Rando OJ, Peterson CL. A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science. 2013 Apr 12; 340(6129):195-9. PMID: 23580526.
      Citations: 108     Fields:    Translation:AnimalsCells
    18. Watanabe S, Peterson CL. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Cold Spring Harb Symp Quant Biol. 2010; 75:35-42. PMID: 21502417.
      Citations: 22     Fields:    Translation:HumansAnimals
    19. Wippo CJ, Israel L, Watanabe S, Hochheimer A, Peterson CL, Korber P. The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes. EMBO J. 2011 Apr 06; 30(7):1277-88. PMID: 21343911.
      Citations: 34     Fields:    Translation:AnimalsCells
    20. Papamichos-Chronakis M, Watanabe S, Rando OJ, Peterson CL. Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity. Cell. 2011 Jan 21; 144(2):200-13. PMID: 21241891.
      Citations: 216     Fields:    Translation:AnimalsCells
    21. Komaba S, Watanabe S, Umeki N, Sato O, Ikebe M. Effect of phosphorylation in the motor domain of human myosin IIIA on its ATP hydrolysis cycle. Biochemistry. 2010 May 04; 49(17):3695-702. PMID: 20192276.
      Citations: 5     Fields:    Translation:HumansCells
    22. Watanabe S, Resch M, Lilyestrom W, Clark N, Hansen JC, Peterson C, Luger K. Structural characterization of H3K56Q nucleosomes and nucleosomal arrays. Biochim Biophys Acta. 2010 May-Jun; 1799(5-6):480-6. PMID: 20100606.
      Citations: 29     Fields:    Translation:Cells
    23. Sinha M, Watanabe S, Johnson A, Moazed D, Peterson CL. Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling. Cell. 2009 Sep 18; 138(6):1109-21. PMID: 19766565.
      Citations: 46     Fields:    Translation:AnimalsCells
    24. Sugimoto Y, Sato O, Watanabe S, Ikebe R, Ikebe M, Wakabayashi K. Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scattering. J Mol Biol. 2009 Sep 18; 392(2):420-35. PMID: 19607837.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Umeki N, Jung HS, Watanabe S, Sakai T, Li XD, Ikebe R, Craig R, Ikebe M. The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8483-8. PMID: 19423668.
      Citations: 50     Fields:    Translation:AnimalsCells
    26. Watanabe S, Umeki N, Ikebe R, Ikebe M. Impacts of Usher syndrome type IB mutations on human myosin VIIa motor function. Biochemistry. 2008 Sep 09; 47(36):9505-13. PMID: 18700726.
      Citations: 11     Fields:    Translation:HumansCells
    27. Watanabe S, Watanabe TM, Sato O, Awata J, Homma K, Umeki N, Higuchi H, Ikebe R, Ikebe M. Human myosin Vc is a low duty ratio nonprocessive motor. J Biol Chem. 2008 Apr 18; 283(16):10581-92. PMID: 18079121.
      Citations: 20     Fields:    Translation:Humans
    28. Watanabe S, Mabuchi K, Ikebe R, Ikebe M. Mechanoenzymatic characterization of human myosin Vb. Biochemistry. 2006 Feb 28; 45(8):2729-38. PMID: 16489766.
      Citations: 19     Fields:    Translation:HumansCells
    29. Watanabe S, Ikebe R, Ikebe M. Drosophila myosin VIIA is a high duty ratio motor with a unique kinetic mechanism. J Biol Chem. 2006 Mar 17; 281(11):7151-60. PMID: 16415346.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    30. Ajtai K, Garamszegi SP, Watanabe S, Ikebe M, Burghardt TP. The myosin cardiac loop participates functionally in the actomyosin interaction. J Biol Chem. 2004 May 28; 279(22):23415-21. PMID: 15020589.
      Citations: 11     Fields:    Translation:AnimalsCells
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