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    Mary Rusckowski PhD

    TitleResearch Associate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentRadiology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-6972
        Bibliographic 
        selected publications
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        1. Sugimoto H, Lebleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med. 2013 Jul; 19(7):810-1.
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        2. Wang Y, Chen L, Liu X, Cheng D, Liu G, Liu Y, Dou S, Hnatowich DJ, Rusckowski M. Detection of Aspergillus fumigatus pulmonary fungal infections in mice with (99m)Tc-labeled MORF oligomers targeting ribosomal RNA. Nucl Med Biol. 2013 Jan; 40(1):89-96.
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        3. Liu X, Nakamura K, Cheng D, Peng C, Xiao N, Liu Y, Chen L, Rusckowski M, Hnatowich DJ. Her2/neu Small Interfering RNA Delivered in Culture by a Streptavidin Nanoparticle. Curr Drug Deliv. 2012 Jul 1; 9(4):431-6.
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        4. Liu X, Cheng D, Gray BD, Wang Y, Akalin A, Rusckowski M, Pak KY, Hnatowich DJ. Radiolabeled Zn-DPA as a potential infection imaging agent. Nucl Med Biol. 2012 Jul; 39(5):709-14.
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        5. Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul; 39(5):645-51.
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        6. Sugimoto H, Lebleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012; 18(3):396-404.
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        7. Liu G, Dou S, Liu Y, Wang Y, Rusckowski M, Hnatowich DJ. (90)Y labeled Phosphorodiamidate Morpholino Oligomer for Pretargeting Radiotherapy. Bioconjug Chem. 2011 Dec 21; 22(12):2539-45.
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        8. Chen L, Wang Y, Cheng D, Dou S, Liu X, Liu G, Hnatowich DJ, Rusckowski M. Comparing two TAG-72 binding peptides previously identified by phage display as potential imaging agents. Nucl Med Commun. 2011 Oct; 32(10):920-4.
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        9. Liu Y, Cheng D, Liu X, Liu G, Dou S, Xiao N, Chen L, Rusckowski M, Hnatowich DJ. Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation. Nucl Med Biol. 2012 Jan; 39(1):101-7.
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        10. Liu G, Dou S, Cheng D, Leif J, Rusckowski M, Streeter PR, Shultz LD, Hnatowich DJ, Greiner DL. Human Islet Cell MORF/cMORF Pretargeting in a Xenogeneic Murine Transplant Model. Mol Pharm. 2011 Jun 6; 8(3):767-73.
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        11. Cheng D, Rusckowski M, Pretorius PH, Chen L, Xiao N, Liu Y, Liu G, Liang M, Liu X, Dou S, Hnatowich DJ. Improving the quantitation accuracy in noninvasive small animal single photon emission computed tomography imaging. Nucl Med Biol. 2011 Aug; 38(6):843-8.
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        12. Hoppin J, Orcutt KD, Hesterman JY, Silva MD, Cheng D, Lackas C, Rusckowski M. Assessing antibody pharmacokinetics in mice with in vivo imaging. J Pharmacol Exp Ther. 2011 May; 337(2):350-8.
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        13. Cheng D, Rusckowski M, Wang Y, Liu Y, Liu G, Liu X, Hnatowich D. A Brief Evaluation of Tumor Imaging in Mice with 99mTc-glucarate Including a Comparison with 18F-FDG. Curr Radiopharm. 2011 Jan 1; 4(1):5-9.
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        14. Xiao N, Cheng D, Wang Y, Chen L, Liu X, Dou S, Liu G, Liang M, Hnatowich DJ, Rusckowski M. Identification of a high affinity TAG-72 binding peptide by phage display selection. Cancer Biol Ther. 2011 Jan 13; 11(1):22-31.
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        15. Liang M, Liu X, Liu G, Dou S, Cheng D, Liu Y, Rusckowski M, Hnatowich DJ. Reducing the background fluorescence in mice receiving fluorophore/inhibitor DNA duplexes. Mol Pharm. 2011 Feb 7; 8(1):126-32.
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        16. Liu G, Dou S, Chen X, Chen L, Liu X, Rusckowski M, Hnatowich DJ. Adding a clearing agent to pretargeting does not lower the tumor accumulation of the effector as predicted. Cancer Biother Radiopharm. 2010 Dec; 25(6):757-62.
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        17. Liu G, Dou S, Liu Y, Liang M, Chen L, Cheng D, Greiner D, Rusckowski M, Hnatowich DJ. Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal. Nucl Med Biol. 2011 Feb; 38(2):159-63.
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        18. Liu G, Dou S, Baker S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. A preclinical (188) Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49. Cancer Biol Ther. 2010 Oct 15; 10(8):767-74.
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        19. Cheng D, Wang Y, Liu X, Pretorius PH, Liang M, Rusckowski M, Hnatowich DJ. Comparison of 18F PET and 99mTc SPECT imaging in phantoms and in tumored mice. Bioconjug Chem. 2010 Aug 18; 21(8):1565-70.
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        20. Liang M, Liu X, Cheng D, Liu G, Dou S, Wang Y, Rusckowski M, Hnatowich DJ. Multimodality nuclear and fluorescence tumor imaging in mice using a streptavidin nanoparticle. Bioconjug Chem. 2010 Jul 21; 21(7):1385-8.
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        21. Liu X, Nakamura K, Wang Y, Cheng D, Liang M, Xiao N, Chen L, Rusckowski M, Hnatowich DJ. Auger-mediated cytotoxicity of cancer cells in culture by an 125I-antisense oligomer delivered as a three-component streptavidin nanoparticle. J Biomed Nanotechnol. 2010 Apr; 6(2):153-7.
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        22. Liu G, Dou S, Rusckowski M, Greiner D, Hnatowich D. Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation. Appl Radiat Isot. 2010 Sep; 68(9):1709-14.
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        23. Liu G, Dou S, Pretorius PH, Liu X, Chen L, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector. Q J Nucl Med Mol Imaging. 2010 Jun; 54(3):333-40.
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        24. Wang Y, Liu X, Chen L, Cheng D, Rusckowski M, Hnatowich DJ. Tumor delivery of antisense oligomer using trastuzumab within a streptavidin nanoparticle. Eur J Nucl Med Mol Imaging. 2009 Dec; 36(12):1977-86.
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        25. Liu G, Dou S, Liang M, Chen X, Rusckowski M, Hnatowich DJ. The ratio of maximum percent tumour accumulations of the pretargeting agent and the radiolabelled effector is independent of tumour size. Eur J Cancer. 2009 Nov; 45(17):3098-103.
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        26. Wang Y, Liu X, Nakamura K, Chen L, Rusckowski M, Hnatowich DJ. In vivo delivery of antisense MORF oligomer by MORF/carrier streptavidin nanoparticles. Cancer Biother Radiopharm. 2009 Oct; 24(5):573-8.
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        27. Liang M, Liu X, Cheng D, Nakamura K, Wang Y, Dou S, Liu G, Rusckowski M, Hnatowich DJ. Optical antisense tumor targeting in vivo with an improved fluorescent DNA duplex probe. Bioconjug Chem. 2009 Jun; 20(6):1223-7.
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        28. Liang M, Liu X, Nakamura K, Chen X, Cheng D, Liu G, Dou S, Wang Y, Rusckowski M, Hnatowich DJ. A convenient thiazole orange fluorescence assay for the evaluation of DNA duplex hybridization stability. Mol Imaging Biol. 2009 Nov-Dec; 11(6):439-45.
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        29. Liu G, Cheng D, Dou S, Chen X, Liang M, Pretorius PH, Rusckowski M, Hnatowich DJ. Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation. Mol Imaging Biol. 2009 Sep-Oct; 11(5):303-7.
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        30. Liu X, Wang Y, Nakamura K, Kawauchi S, Akalin A, Cheng D, Chen L, Rusckowski M, Hnatowich DJ. Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In. J Nucl Med. 2009 Apr; 50(4):582-90.
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        31. Chen L, Wang Y, Liu X, Dou S, Liu G, Hnatowich DJ, Rusckowski M. A new TAG-72 cancer marker peptide identified by phage display. Cancer Lett. 2008 Dec 8; 272(1):122-32.
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        32. Chen X, Dou S, Liu G, Liu X, Wang Y, Chen L, Rusckowski M, Hnatowich DJ. Synthesis and in vitro characterization of a dendrimer-MORF conjugate for amplification pretargeting. Bioconjug Chem. 2008 Aug; 19(8):1518-25.
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        33. Liu G, Dou S, Rusckowski M, Hnatowich DJ. An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector. Mol Cancer Ther. 2008 May; 7(5):1025-32.
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        34. Kleine LG, Solano M, Rusckowski M, Hunt KE, Johnson KL, Kirker-Head CA. Evaluation of technetium Tc 99m-labeled biotin for scintigraphic detection of soft tissue inflammation in horses. Am J Vet Res. 2008 May; 69(5):639-46.
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        35. Rusckowski M, Gupta S, Liu G, Dou S, Hnatowich DJ. Investigation of four (99m)Tc-labeled bacteriophages for infection-specific imaging. Nucl Med Biol. 2008 May; 35(4):433-40.
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        36. Liu X, Wang Y, Nakamura K, Liu G, Dou S, Kubo A, Rusckowski M, Hnatowich DJ. Optical antisense imaging of tumor with fluorescent DNA duplexes. Bioconjug Chem. 2007 Nov-Dec; 18(6):1905-11.
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        37. Liu G, Dou S, Pretorius PH, Liu X, Rusckowski M, Hnatowich DJ. Pretargeting CWR22 prostate tumor in mice with MORF-B72.3 antibody and radiolabeled cMORF. Eur J Nucl Med Mol Imaging. 2008 Feb; 35(2):272-80.
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        38. Rusckowski M, Gupta S, Liu G, Dou S, Hnatowich DJ. Evidence of specificity of radiolabeled phage display peptides for the TAG-72 antigen. Cancer Biother Radiopharm. 2007 Aug; 22(4):564-72.
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        39. Zhang S, Liu G, Liu X, Yin D, Dou S, He J, Rusckowski M, Hnatowich DJ. Comparison of several linear fluorophore- and quencher-conjugated oligomer duplexes for stability, fluorescence quenching, and kinetics in vitro and in vivo in mice. Bioconjug Chem. 2007 Jul-Aug; 18(4):1170-5.
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        40. He J, Liu G, Dou S, Gupta S, Rusckowski M, Hnatowich D. An improved method for covalently conjugating morpholino oligomers to antitumor antibodies. Bioconjug Chem. 2007 May-Jun; 18(3):983-8.
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        41. Liu G, Dou S, Yin D, Squires S, Liu X, Wang Y, Rusckowski M, Hnatowich DJ. A novel pretargeting method for measuring antibody internalization in tumor cells. Cancer Biother Radiopharm. 2007 Feb; 22(1):33-9.
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        42. Liu G, Dou S, He J, Liu X, Rusckowski M, Hnatowich DJ. Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice. Eur J Nucl Med Mol Imaging. 2007 Feb; 34(2):237-46.
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        43. He J, Rusckowski M, Wang Y, Dou S, Liu X, Zhang S, Liu G, Hnatowich DJ. Optical pretargeting of tumor with fluorescent MORF oligomers. Mol Imaging Biol. 2007 Jan-Feb; 9(1):17-23.
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        44. Wang Y, Liu X, Zhang Y, Liu G, Rusckowski M, Hnatowich DJ. Nonspecific cellular accumulation of 99mTc-labeled oligonucleotides in culture is influenced by their guanine content. Nucl Med Biol. 2007 Jan; 34(1):47-54.
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        45. Liu X, Nakamura K, Wang Y, Zhang S, He J, Liu G, Dou S, Kubo A, Rusckowski M, Hnatowich D. Improved delivery in cell culture of radiolabeled antisense DNAs by duplex formation. Mol Imaging Biol. 2006 Sep-Oct; 8(5):278-83.
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        46. Liu G, Dou S, Mardirossian G, He J, Zhang S, Liu X, Rusckowski M, Hnatowich DJ. Successful radiotherapy of tumor in pretargeted mice by 188Re-radiolabeled phosphorodiamidate morpholino oligomer, a synthetic DNA analogue. Clin Cancer Res. 2006 Aug 15; 12(16):4958-64.
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        47. Liu G, Dou S, He J, Yin D, Gupta S, Zhang S, Wang Y, Rusckowski M, Hnatowich DJ. Radiolabeling of MAG3-morpholino oligomers with 188Re at high labeling efficiency and specific radioactivity for tumor pretargeting. Appl Radiat Isot. 2006 Sep; 64(9):971-8.
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        48. Liu X, Nakamura K, Wang Y, Wang Y, Liu G, He J, Ding H, Lu P, Rusckowski M, Kubo A, Hnatowich DJ. Initial mechanistic studies of antisense targeting in cells. J Nucl Med. 2006 Feb; 47(2):360-8.
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        49. Zhang YM, Tung CH, He J, Liu N, Yanachkov I, Liu G, Rusckowski M, Vanderheyden JL. Construction of a novel chimera consisting of a chelator-containing Tat peptide conjugated to a morpholino antisense oligomer for technetium-99m labeling and accelerating cellular kinetics. Nucl Med Biol. 2006 Feb; 33(2):263-9.
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        50. Liu G, He J, Dou S, Gupta S, Rusckowski M, Hnatowich DJ. Further investigations of morpholino pretargeting in mice--establishing quantitative relations in tumor. Eur J Nucl Med Mol Imaging. 2005 Sep; 32(9):1115-23.
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        51. Liu G, Dou S, He J, Vanderheyden JL, Rusckowski M, Hnatowich DJ. Preparation and properties of 99mTc(CO)3+-labeled N,N-bis(2-pyridylmethyl)-4-aminobutyric acid. Bioconjug Chem. 2004 Nov-Dec; 15(6):1441-6.
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        52. Nakamura K, Fan C, Liu G, Gupta S, He J, Dou S, Kubo A, Rusckowski M, Hnatowich DJ. Evidence of antisense tumor targeting in mice. Bioconjug Chem. 2004 Nov-Dec; 15(6):1475-80.
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        53. Zhang Y, He J, Liu G, Venderheyden JL, Gupta S, Rusckowski M, Hnatowich DJ. Initial observations of 99mTc labelled locked nucleic acids for antisense targeting. Nucl Med Commun. 2004 Nov; 25(11):1113-8.
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        54. He J, Liu C, Vanderheyden JL, Liu G, Dou S, Rusckowski M, Hnatowich DJ. Radiolabelling morpholinos with 188Re tricarbonyl provides improved in vitro and in vivo stability to re-oxidation. Nucl Med Commun. 2004 Jul; 25(7):731-6.
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        55. Rusckowski M, Gupta S, Liu G, Dou S, Hnatowich DJ. Investigations of a (99m)Tc-labeled bacteriophage as a potential infection-specific imaging agent. J Nucl Med. 2004 Jul; 45(7):1201-8.
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        56. He J, Liu G, Gupta S, Zhang Y, Rusckowski M, Hnatowich DJ. Amplification targeting: a modified pretargeting approach with potential for signal amplification-proof of a concept. J Nucl Med. 2004 Jun; 45(6):1087-95.
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        57. Liu G, He J, Dou S, Gupta S, Vanderheyden JL, Rusckowski M, Hnatowich DJ. Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake. Eur J Nucl Med Mol Imaging. 2004 Mar; 31(3):417-24.
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        58. He J, Liu G, Zhang S, Rusckowski M, Hnatowich DJ. Pharmacokinetics in mice of four oligomer-conjugated polymers for amplification targeting. Cancer Biother Radiopharm. 2003 Dec; 18(6):941-7.
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        59. He J, Liu G, Zhang S, Vanderheyden JL, Liu N, Liu C, Zhang Y, Gupta S, Rusckowski M, Hnatowich DJ. A comparison of in vitro and in vivo stability in mice of two morpholino duplexes differing in chain length. Bioconjug Chem. 2003 Sep-Oct; 14(5):1018-23.
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        60. Ferro-Flores G, Arteaga de Murphy C, Pedraza-López M, Meléndez-Alafort L, Zhang YM, Rusckowski M, Hnatowich DJ. In vitro and in vivo assessment of 99mTc-UBI specificity for bacteria. Nucl Med Biol. 2003 Aug; 30(6):597-603.
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        61. Zhang YM, Liu CB, Liu N, Ferro Flores G, He J, Rusckowski M, Hnatowich DJ. Electrostatic binding with tat and other cationic peptides increases cell accumulation of 99mTc-antisense DNAs without entrapment. Mol Imaging Biol. 2003 Jul-Aug; 5(4):240-7.
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        62. Liu G, Liu C, Zhang S, He J, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. Investigations of 99mTc morpholino pretargeting in mice. Nucl Med Commun. 2003 Jun; 24(6):697-705.
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        63. Su ZF, He J, Rusckowski M, Hnatowich DJ. In vitro cell studies of technetium-99m labeled RGD-HYNIC peptide, a comparison of tricine and EDDA as co-ligands. Nucl Med Biol. 2003 Feb; 30(2):141-9.
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        64. Liu CB, Liu GZ, Liu N, Zhang YM, He J, Rusckowski M, Hnatowich DJ. Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc. Nucl Med Biol. 2003 Feb; 30(2):207-14.
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        65. Liu G, He J, Zhang S, Liu C, Rusckowski M, Hnatowich DJ. Cytosine residues influence kidney accumulations of 99mTc-labeled morpholino oligomers. Antisense Nucleic Acid Drug Dev. 2002 Dec; 12(6):393-8.
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        66. Liu G, Zhang S, He J, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. The influence of chain length and base sequence on the pharmacokinetic behavior of 99mTc-morpholinos in mice. Q J Nucl Med. 2002 Sep; 46(3):233-43.
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        67. Liu G, Zhang S, He J, Zhu Z, Rusckowski M, Hnatowich DJ. Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers. Bioconjug Chem. 2002 Jul-Aug; 13(4):893-7.
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        68. Su ZF, Liu G, Gupta S, Zhu Z, Rusckowski M, Hnatowich DJ. In vitro and in vivo evaluation of a Technetium-99m-labeled cyclic RGD peptide as a specific marker of alpha(V)beta(3) integrin for tumor imaging. Bioconjug Chem. 2002 May-Jun; 13(3):561-70.
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        69. Liu G, Mang'era K, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog. J Nucl Med. 2002 Mar; 43(3):384-91.
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        70. Liu G, Wescott C, Sato A, Wang Y, Liu N, Zhang YM, Rusckowski M, Hnatowich DJ. Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide. Nucl Med Biol. 2002 Jan; 29(1):107-13.
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        71. Rusckowski M, Qu T, Gupta S, Ley A, Hnatowich DJ. A comparison in monkeys of (99m)Tc labeled to a peptide by 4 methods. J Nucl Med. 2001 Dec; 42(12):1870-7.
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        72. Zhang YM, Wang Y, Liu N, Zhu ZH, Rusckowski M, Hnatowich DJ. In vitro investigations of tumor targeting with (99m)Tc-labeled antisense DNA. J Nucl Med. 2001 Nov; 42(11):1660-9.
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        73. Mang'era KO, Liu G, Yi W, Zhang Y, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. Initial investigations of 99mTc-labeled morpholinos for radiopharmaceutical applications. Eur J Nucl Med. 2001 Nov; 28(11):1682-9.
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        74. Zhang YM, Rusckowski M, Liu N, Liu C, Hnatowich DJ. Cationic liposomes enhance cellular/nuclear localization of 99mTc-antisense oligonucleotides in target tumor cells. Cancer Biother Radiopharm. 2001 Oct; 16(5):411-9.
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        75. Wang Y, Chang F, Zhang Y, Liu N, Liu G, Gupta S, Rusckowski M, Hnatowich DJ. Pretargeting with amplification using polymeric peptide nucleic acid. Bioconjug Chem. 2001 Sep-Oct; 12(5):807-16.
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        76. Zhu Z, Wang Y, Zhang Y, Liu G, Liu N, Rusckowski M, Hnatowich DJ. A novel and simplified route to the synthesis of N3S chelators for 99mTc labeling. Nucl Med Biol. 2001 Aug; 28(6):703-8.
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        77. Qu T, Wang Y, Zhu Z, Rusckowski M, Hnatowich DJ. Different chelators and different peptides together influence the in vitro and mouse in vivo properties of 99Tcm. Nucl Med Commun. 2001 Feb; 22(2):203-15.
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        78. Zhang YM, Liu N, Zhu ZH, Rusckowski M, Hnatowich DJ. Influence of different chelators (HYNIC, MAG3 and DTPA) on tumor cell accumulation and mouse biodistribution of technetium-99m labeled to antisense DNA. Eur J Nucl Med. 2000 Nov; 27(11):1700-7.
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        79. Rusckowski M, Qu T, Roskey A, Agrawal S. Biodistribution and metabolism of a mixed backbone oligonucleotide (GEM 231) following single and multiple dose administration in mice. Antisense Nucleic Acid Drug Dev. 2000 Oct; 10(5):333-45.
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        80. Rusckowski M, Qu T, Pullman J, Marcel R, Ley AC, Ladner RC, Hnatowich DJ. Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys. J Nucl Med. 2000 Feb; 41(2):363-74.
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        81. Hnatowich DJ, Chang F, Qu T, Rusckowski M. Technetium-99m labeled peptides--an investigation of multiple HPLC peaks. Appl Radiat Isot. 1999 May; 50(5):911-21.
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        82. Chang F, Qu T, Rusckowski M, Hnatowich DJ. NHS-MAS3: a bifunctional chelator alternative to NHS-MAG3. Appl Radiat Isot. 1999 Apr; 50(4):723-32.
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        83. Fogarasi M, Pullman J, Winnard P, Hnatowich DJ, Rusckowski M. Pretargeting of bacterial endocarditis in rats with streptavidin and 111In-labeled biotin. J Nucl Med. 1999 Mar; 40(3):484-90.
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        84. Hnatowich DJ, Qu T, Chang F, Ley AC, Ladner RC, Rusckowski M. Labeling peptides with technetium-99m using a bifunctional chelator of a N-hydroxysuccinimide ester of mercaptoacetyltriglycine. J Nucl Med. 1998 Jan; 39(1):56-64.
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        85. Rusckowski M, Qu T, Chang F, Hnatowich DJ. Pretargeting using peptide nucleic acid. Cancer. 1997 Dec 15; 80(12 Suppl):2699-705.
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        86. Chang F, Rusckowski M, Qu T, Hnatowich DJ. Early results in the irrational design of new bifunctional chelators. Cancer. 1997 Dec 15; 80(12 Suppl):2347-53.
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        87. Rusckowski M, Qu T, Chang F, Hnatowich DJ. Technetium-99m labeled epidermal growth factor-tumor imaging in mice. J Pept Res. 1997 Nov; 50(5):393-401.
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        88. Winnard P, Chang F, Rusckowski M, Mardirossian G, Hnatowich DJ. Preparation and use of NHS-MAG3 for technetium-99m labeling of DNA. Nucl Med Biol. 1997 Jul; 24(5):425-32.
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        89. Mardirossian G, Lei K, Rusckowski M, Chang F, Qu T, Egholm M, Hnatowich DJ. In vivo hybridization of technetium-99m-labeled peptide nucleic acid (PNA). J Nucl Med. 1997 Jun; 38(6):907-13.
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        90. Hnatowich DJ, Chang F, Lei K, Qu T, Rusckowski M. The influence of temperature and alkaline pH on the labeling of free and conjugated MAG3 with technetium-99m. Appl Radiat Isot. 1997 May; 48(5):587-94.
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        91. Rusckowski M, Fogarasi M, Fritz B, Hnatowich DJ. Effect of endogenous biotin on the applications of streptavidin and biotin in mice. Nucl Med Biol. 1997 Apr; 24(3):263-8.
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        92. Rusckowski M, Paganelli G, Hnatowich DJ, Magnani P, Virzi F, Fogarasi M, DiLeo C, Sudati F, Fazio F. Imaging osteomyelitis with streptavidin and indium-111-labeled biotin. J Nucl Med. 1996 Oct; 37(10):1655-62.
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        93. Lei K, Rusckowski M, Chang F, Qu T, Mardirossian G, Hnatowich DJ. Technetium-99m antibodies labeled with MAG3 and SHNH: an in vitro and animal in vivo comparison. Nucl Med Biol. 1996 Oct; 23(7):917-22.
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        94. Winnard P, Virzi E, Fogarasi M, Rusckowski M, Hnatowich DJ. Investigations of directly labeling antibodies with rhenium-188. Q J Nucl Med. 1996 Jun; 40(2):151-60.
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        95. Hnatowich DJ, Mardirossian G, Rusckowski M, Winnard P. Protein labelling via deoxyribonucleic acid hybridization. Nucl Med Commun. 1996 Jan; 17(1):66-75.
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        96. Hnatowich DJ, Mardirossian G, Fogarasi M, Sano T, Smith CL, Cantor CR, Rusckowski M, Winnard P. Comparative properties of a technetium-99m-labeled single-stranded natural DNA and a phosphorothioate derivative in vitro and in mice. J Pharmacol Exp Ther. 1996 Jan; 276(1):326-34.
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        97. Hnatowich DJ, Winnard P, Virzi F, Fogarasi M, Sano T, Smith CL, Cantor CR, Rusckowski M. Technetium-99m labeling of DNA oligonucleotides. J Nucl Med. 1995 Dec; 36(12):2306-14.
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        98. Virzi F, Winnard P, Fogarasi M, Sano T, Smith CL, Cantor CR, Rusckowski M, Hnatowich DJ. Recombinant metallothionein-conjugated streptavidin labeled with 188Re and 99mTc. Bioconjug Chem. 1995 Jan-Feb; 6(1):139-44.
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        99. Rusckowski M, Fogarasi M, Virzi F, Hnatowich DJ. Influence of endogenous biotin on the biodistribution of labelled biotin derivatives in mice. Nucl Med Commun. 1995 Jan; 16(1):38-46.
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        100. Hnatowich DJ, Virzi F, Fogarasi M, Rusckowski M, Winnard P. Can a cysteine challenge assay predict the in vivo behavior of 99mTc-labeled antibodies? Nucl Med Biol. 1994 Nov; 21(8):1035-44.
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        101. Hnatowich DJ, Virzi F, Winnard P, Fogarasi M, Rusckowski M. Investigations of ascorbate for direct labeling of antibodies with technetium-99m. J Nucl Med. 1994 Jan; 35(1):127-34.
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        102. Hnatowich DJ, Fritz B, Virzi F, Mardirossian G, Rusckowski M. Improved tumor localization with (strept)avidin and labeled biotin as a substitute for antibody. Nucl Med Biol. 1993 Feb; 20(2):189-95.
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        103. Hnatowich DJ, Mardirossian G, Rusckowski M, Fogarasi M, Virzi F, Winnard P. Directly and indirectly technetium-99m-labeled antibodies--a comparison of in vitro and animal in vivo properties. J Nucl Med. 1993 Jan; 34(1):109-19.
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        104. Hnatowich DJ, Mardirossian G, Rusckowski M, Roy S, Bushe H, Griffin TW, Brill AB. Pharmacokinetics of the FO23C5 anti-CEA antibody fragment labelled with 99Tcm and 111In: a comparison in patients. Nucl Med Commun. 1993 Jan; 14(1):52-63.
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        105. Rusckowski M, Fritz B, Hnatowich DJ. Localization of infection using streptavidin and biotin: an alternative to nonspecific polyclonal immunoglobulin. J Nucl Med. 1992 Oct; 33(10):1810-5.
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        106. Mardirossian G, Wu C, Rusckowski M, Hnatowich DJ. The stability of 99Tcm directly labelled to an Fab' antibody via stannous ion and mercaptoethanol reduction. Nucl Med Commun. 1992 Jul; 13(7):503-12.
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        107. Hnatowich DJ, Rusckowski M, Siebecker DA, Gionet M, Mardirossian G, Bushe HS, Roy S, Mattis JA, Shealy D, Griffin TW, et al. Pharmacokinetics of indium-111 labeled 10-3D2 antibreast-tumor antibody in patients. J Nucl Biol Med. 1992 Jan-Mar; 36(1):7-13.
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        108. Griffin TW, Brill AB, Stevens S, Collins JA, Bokhari F, Bushe H, Stochl MC, Gionet M, Rusckowski M, Stroupe SD, et al. Initial clinical study of indium-111-labeled clone 110 anticarcinoembryonic antigen antibody in patients with colorectal cancer. J Clin Oncol. 1991 Apr; 9(4):631-40.
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        109. Virzi F, Fritz B, Rusckowski M, Gionet M, Misra H, Hnatowich DJ. New indium-111 labeled biotin derivatives for improved immunotargeting. Int J Rad Appl Instrum B. 1991; 18(7):719-26.
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        110. Hnatowich DJ, Rusckowski M, Brill AB, Siebecker DA, Misra H, Mardirossian G, Bushe H, Rescigno A, Stevens S, Johnson DK, et al. Pharmacokinetics in patients of an anti-carcinoembryonic antigen antibody radiolabeled with indium-111 using a novel diethylenetriamine pentaacetic acid chelator. Cancer Res. 1990 Nov 15; 50(22):7272-8.
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        111. Kalofonos HP, Rusckowski M, Siebecker DA, Sivolapenko GB, Snook D, Lavender JP, Epenetos AA, Hnatowich DJ. Imaging of tumor in patients with indium-111-labeled biotin and streptavidin-conjugated antibodies: preliminary communication. J Nucl Med. 1990 Nov; 31(11):1791-6.
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        112. Rescigno A, Bushe H, Brill AB, Rusckowski M, Griffin TW, Hnatowich DJ. Pharmacokinetic modeling of radiolabeled antibody distribution in man. Am J Physiol Imaging. 1990; 5(4):141-50.
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        113. Hnatowich DJ, Gionet M, Rusckowski M, Siebecker DA, Roche J, Shealy D, Mattis JA, Wilson J, McGann J, Hunter RE, et al. Pharmacokinetics of 111In-labeled OC-125 antibody in cancer patients compared with the 19-9 antibody. Cancer Res. 1987 Nov 15; 47(22):6111-7.
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        114. Hnatowich DJ, Virzi F, Rusckowski M. Investigations of avidin and biotin for imaging applications. J Nucl Med. 1987 Aug; 28(8):1294-302.
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        115. Hnatowich DJ, Griffin TW, Kosciuczyk C, Rusckowski M, Childs RL, Mattis JA, Shealy D, Doherty PW. Pharmacokinetics of an indium-111-labeled monoclonal antibody in cancer patients. J Nucl Med. 1985 Aug; 26(8):849-58.
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        116. Rusckowski M, Doherty PW, Virzi F, Hnatowich DJ. A simple in vitro method of screening panels of monoclonal antibodies for tumor binding. J Immunol Methods. 1985 Feb 11; 76(2):375-82.
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