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    Kate L Lapane PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentQuantitative Health Sciences
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North, AC7-073
    Worcester MA 01655
    Phone508-856-8965
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentClinical Population Health Research

        Overview 
        Narrative

        Dr. Lapane is currently a Professor in Quantitative Health Sciences and the Associate Dean of Clinical and Population Health Research.  Her primary research interests falls under the umbrella of medication issues in vulnerable populations.  She has performed drug utilization studies, often evaluating the contextual, organizational, policy impacts on patterns of prescription drug use among nursing home residents.  Dr. Lapane has also conducted a series of non-experimental comparative effectiveness research studies of medications in populations systematically excluded from clinical trials.  She has used large administrative claims databases to estimate the risks associated with appropriate medication use.  Dr. Lapane has conducted large scale intervention trials to improve medication related issues in marginalized populations.  She has led the development and implementation of two large nursing home trials in which she assembled separate expert panels to assist in reviewing the intervention materials and focus.  She has also participated in consensus panels related to inappropriate medication use in older adults. Collaborating with the National Osteoarthritis Initiative, she also has evaluated the use of complementary and alternative medicine and the effectiveness of these treatments in patients with osteoarthritis. Dr. Lapane’s methodological work has focused on the robustness of techniques and the appropriate application of techniques often used in non-experimental comparative effectiveness research.  Dr. Lapane has had ~15 years of uninterrupted federal support in conducting studies relating to medication use, as well as multisite randomized trials of novel care models. 



        Bibliographic 
        selected publications
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        1. Pimentel CB, Lapane KL, Briesacher BA. Medicare part d and long-term care: a systematic review of quantitative and qualitative evidence. Drugs Aging. 2013 Sep; 30(9):701-20.
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        2. Bajaj JS, Ratliff S, Lapane K. Commentary: non-haemodynamic effects of beta-blockers in cirrhosis - more than meets the eye? Authors' reply. Aliment Pharmacol Ther. 2013 Sep; 38(6):653.
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        3. Motzkus-Feagans C, Pakyz AL, Ratliff SM, Bajaj JS, Lapane KL. Statin use and infections in Veterans with cirrhosis. Aliment Pharmacol Ther. 2013 Sep; 38(6):611-8.
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        4. Lu B, Ahmad O, Zhang FF, Driban JB, Duryea J, Lapane KL, McAlindon T, Eaton CB. Soft drink intake and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative. BMJ Open. 2013; 3(7).
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        5. Tjia J, Allison J, Saczynski JS, Tisminetzky M, Givens JL, Lapane K, Lessard D, Goldberg RJ. Encouraging trends in acute myocardial infarction survival in the oldest old. Am J Med. 2013 Sep; 126(9):798-804.
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        6. Lapane KL, Yang S, Brown MJ, Jawahar R, Pagliasotti C, Rajpathak S. Sulfonylureas and risk of falls and fractures: a systematic review. Drugs Aging. 2013 Jul; 30(7):527-47.
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        7. Bajaj JS, Ratliff SM, Heuman DM, Lapane KL. Non-selective beta-blockers are not associated with serious infections in veterans with cirrhosis. Aliment Pharmacol Ther. 2013 Aug; 38(4):407-14.
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        8. Pugsley RA, Chapman DA, Kennedy MG, Liu H, Lapane KL. Residential Segregation and Gonorrhea Rates in US Metropolitan Statistical Areas, 2005-2009. Sex Transm Dis. 2013 Jun; 40(6):439-43.
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        9. Lapane KL, Quilliam BJ, Benson C, Chow W, Kim MS. Gastrointestinal events after opioid treatment in nonmalignant pain: Correlates of occurrence and impact on health-related quality of life. J Opioid Manag. 2013 May-Jun; 9(3):205-16.
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        10. Mezuk B, Lohman M, Dumenci L, Lapane KL. Are Depression and Frailty Overlapping Syndromes in Mid- and Late-life? A Latent Variable Analysis. Am J Geriatr Psychiatry. 2013 Jun; 21(6):560-9.
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        11. Lapane KL, Goldman RE, Quilliam BJ, Hume AL, Eaton CB. Tailored DVDs: A novel strategy for educating racially and ethnically diverse older adults about their medicines. Int J Med Inform. 2012 Oct 30.
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        12. Bajaj JS, Ratliff SM, Heuman DM, Lapane KL. Proton pump inhibitors are associated with a high rate of serious infections in veterans with decompensated cirrhosis. Aliment Pharmacol Ther. 2012 Sep 11; 36(9):866-874.
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        13. Jawahar R, Yang S, Eaton CB, McAlindon T, Lapane KL. Gender-specific correlates of complementary and alternative medicine use for knee osteoarthritis. J Womens Health (Larchmt). 2012 Oct; 21(10):1091-9.
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        14. Lapane KL, Quilliam BJ, Chow W, Kim MS. Pharmacologic Management of Non-Cancer Pain Among Nursing Home Residents. J Pain Symptom Manage. 2012 Jul 26.
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        15. Yang S, Jawahar R, McAlindon TE, Eaton CB, Lapane KL. Racial differences in symptom management approaches among persons with radiographic knee osteoarthritis. BMC Complement Altern Med. 2012; 12:86.
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        16. Magnusson BM, Sabik L, Chapman DA, Masho SW, Lafata JE, Bradley CJ, Lapane KL. Contraceptive insurance mandates and consistent contraceptive use among privately insured women. Med Care. 2012 Jul; 50(7):562-8.
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        17. Mezuk B, Lohman M, Dumenci L, Lapane KL. Are Depression and Frailty Overlapping Syndromes in Mid- and Late-life? A Latent Variable Analysis. Am J Geriatr Psychiatry. 2012 May 16.
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        18. Lapane KL, Quilliam BJ, Chow W, Kim MS. Impact of Revisions to the F-Tag 309 Surveyors' Interpretive Guidelines on Pain Management among Nursing Home Residents. Drugs Aging. 2012 May 1; 29(5):385-93.
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        19. Ezeamama AE, McGarvey ST, Hogan J, Lapane KL, Bellinger DC, Acosta LP, Leenstra T, Olveda RM, Kurtis JD, Friedman JF. Treatment for Schistosoma japonicum, Reduction of Intestinal Parasite Load, and Cognitive Test Score Improvements in School-Aged Children. PLoS Negl Trop Dis. 2012 May; 6(5):e1634.
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        20. Clyne B, Bradley MC, Hughes C, Fahey T, Lapane KL. Electronic prescribing and other forms of technology to reduce inappropriate medication use and polypharmacy in older people: a review of current evidence. Clin Geriatr Med. 2012 May; 28(2):301-22.
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        21. Lapane KL, Cooke ME. Coffee or camaraderie? Arch Intern Med. 2012 Apr 9; 172(7):595.
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        22. Motzkus-Feagans CA, Pakyz A, Polk R, Gambassi G, Lapane KL. Statin use and the risk of Clostridium difficile in academic medical centres. Gut. 2012 Nov; 61(11):1538-42.
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        23. Lapane KL, Magnusson BM. Intervene earlier to help women maintain control of reproductive decision making. Contraception. 2012 Oct; 86(4):425.
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        24. Lapane KL, Motzkus-Feagans C, Pakyz A. Clostridium difficile infection and colonization. N Engl J Med. 2012 Jan 19; 366(3):276; author reply 276-7.
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        25. Lu J, Gary KW, Neimeier JP, Ward J, Lapane KL. Randomized controlled trials in adult traumatic brain injury. Brain Inj. 2012; 26(13-14):1523-48.
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        26. Lapane KL, Sands MR, Yang S, McAlindon TE, Eaton CB. Use of complementary and alternative medicine among patients with radiographic-confirmed knee osteoarthritis. Osteoarthritis Cartilage. 2012 Jan; 20(1):22-8.
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        27. Magnusson BM, Masho SW, Lapane KL. Early age at first intercourse and subsequent gaps in contraceptive use. J Womens Health (Larchmt). 2012 Jan; 21(1):73-9.
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        28. Mezuk B, Edwards L, Lohman M, Choi M, Lapane K. Depression and frailty in later life: a synthetic review. Int J Geriatr Psychiatry. 2012 Sep; 27(9):879-92.
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        29. Lu J, Marmarou A, Lapane KL. Impact of GOS misclassification on ordinal outcome analysis of traumatic brain injury clinical trials. J Neurotrauma. 2012 Mar 20; 29(5):719-26.
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        30. Hume AL, Quilliam BJ, Goldman R, Eaton C, Lapane KL. Alternatives to potentially inappropriate medications for use in e-prescribing software: triggers and treatment algorithms. BMJ Qual Saf. 2011 Oct; 20(10):875-84.
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        31. Nunes AP, Lapane KL, Weinstock MA. Association between non-steroidal anti-inflammatory drugs and keratinocyte carcinomas of the skin among participants in the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Pharmacoepidemiol Drug Saf. 2011 Sep; 20(9):922-9.
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        32. Lapane KL, Hughes CM, Daiello LA, Cameron KA, Feinberg J. Effect of a pharmacist-led multicomponent intervention focusing on the medication monitoring phase to prevent potential adverse drug events in nursing homes. J Am Geriatr Soc. 2011 Jul; 59(7):1238-45.
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        33. Jalbert JJ, Daiello LA, Eaton CB, Miller SC, Lapane KL. Antipsychotic use and the risk of diabetes in nursing home residents with dementia. Am J Geriatr Pharmacother. 2011 Jun; 9(3):153-63.
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        34. Patterson SM, Hughes CM, Cardwell C, Lapane KL, Murray AM, Crealey GE. A cluster randomized controlled trial of an adapted U.S. model of pharmaceutical care for nursing home residents in Northern Ireland (Fleetwood Northern Ireland study): a cost-effectiveness analysis. J Am Geriatr Soc. 2011 Apr; 59(4):586-93.
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        35. Lapane KL, Quilliam BJ, Chow W, Kim M. The association between pain and measures of well-being among nursing home residents. J Am Med Dir Assoc. 2012 May; 13(4):344-9.
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        36. Magnusson BM, Masho SW, Lapane KL. Adolescent and sexual history factors influencing reproductive control among women aged 18-44. Sex Health. 2011 Mar; 8(1):95-101.
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        37. Parsons C, Lapane K, Kerse N, Hughes C. Prescribing for older people in nursing homes: a review of the key issues. Int J Older People Nurs. 2011 Mar; 6(1):45-54.
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        38. Hughes C, Lapane K, Kerse N. Prescribing for older people in nursing homes: challenges for the future. Int J Older People Nurs. 2011 Mar; 6(1):63-70.
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        39. Parsons PL, Mezuk B, Ratliff S, Lapane KL. Subsidized housing not subsidized health: health status and fatigue among elders in public housing and other community settings. Ethn Dis. 2011; 21(1):85-90.
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        40. Lapane KL, Rosen RK, Dubé C. Perceptions of e-prescribing efficiencies and inefficiencies in ambulatory care. Int J Med Inform. 2011 Jan; 80(1):39-46.
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        41. Schneider KL, Clark MA, Rakowski W, Lapane KL. Evaluating the impact of non-response bias in the Behavioral Risk Factor Surveillance System (BRFSS). J Epidemiol Community Health. 2012 Apr; 66(4):290-5.
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        42. Lapane KL, Hughes CM, Christian JB, Daiello LA, Cameron KA, Feinberg J. Evaluation of the fleetwood model of long-term care pharmacy. J Am Med Dir Assoc. 2011 Jun; 12(5):355-63.
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        43. Lapane K. Antihypertensive medication adherence stroke and death. J Gen Intern Med. 2010 Aug; 25(8):762; author reply 764.
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        44. Parsons C, Hughes CM, Passmore AP, Lapane KL. Withholding, discontinuing and withdrawing medications in dementia patients at the end of life: a neglected problem in the disadvantaged dying? Drugs Aging. 2010 Jun 1; 27(6):435-49.
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        45. Goldman RE, Dubé C, Lapane KL. Beyond the basics: refills by electronic prescribing. Int J Med Inform. 2010 Jul; 79(7):507-14.
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        46. Lu J, Marmarou A, Lapane K, Turf E, Wilson L. A method for reducing misclassification in the extended Glasgow Outcome Score. J Neurotrauma. 2010 May; 27(5):843-52.
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        47. Lapane KL. Three graveyard shifts as a nurse's aide: lessons of a lifetime. J Am Med Dir Assoc. 2010 May; 11(4):294-5.
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        48. Waring ME, Eaton CB, Lasater TM, Lapane KL. Correlates of weight patterns during middle age characterized by functional principal components analysis. Ann Epidemiol. 2010 Mar; 20(3):201-9.
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        49. Waring ME, Eaton CB, Lasater TM, Lapane KL. Incident diabetes in relation to weight patterns during middle age. Am J Epidemiol. 2010 Mar 1; 171(5):550-6.
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        50. Jalbert JJ, Eaton CB, Miller SC, Lapane KL. Antipsychotic use and the risk of hip fracture among older adults afflicted with dementia. J Am Med Dir Assoc. 2010 Feb; 11(2):120-7.
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        51. Patterson SM, Hughes CM, Crealey G, Cardwell C, Lapane KL. An evaluation of an adapted U.S. model of pharmaceutical care to improve psychoactive prescribing for nursing home residents in northern ireland (fleetwood northern ireland study). J Am Geriatr Soc. 2010 Jan; 58(1):44-53.
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        52. Dore DD, Trivedi AN, Mor V, Friedman JH, Lapane KL. Atypical antipsychotic use and risk of fracture in persons with Parkinsonism. Mov Disord. 2009 Oct 15; 24(13):1941-8.
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        53. Liperoti R, Onder G, Landi F, Lapane KL, Mor V, Bernabei R, Gambassi G. All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study. J Clin Psychiatry. 2009 Oct; 70(10):1340-7.
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        54. Schneider KL, Lapane KL, Clark MA, Rakowski W. Using small-area estimation to describe county-level disparities in mammography. Prev Chronic Dis. 2009 Oct; 6(4):A125.
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        55. Dore DD, Trivedi AN, Mor V, Lapane KL. Association between extent of thiazolidinedione exposure and risk of acute myocardial infarction. Pharmacotherapy. 2009 Jul; 29(7):775-83.
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        56. Magnusson B, Lapane K. Fathers' pregnancy intentions. Perspect Sex Reprod Health. 2009 Jun; 41(2):132.
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        57. Liu SY, Lapane KL. Residential modifications and decline in physical function among community-dwelling older adults. Gerontologist. 2009 Jun; 49(3):344-54.
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        58. Daiello LA, Ott BR, Lapane KL, Reinert SE, Machan JT, Dore DD. Effect of discontinuing cholinesterase inhibitor therapy on behavioral and mood symptoms in nursing home patients with dementia. Am J Geriatr Pharmacother. 2009 Apr; 7(2):74-83.
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        59. Dore DD, Lapane KL, Trivedi AN, Mor V, Weinstock MA. Association between statin use and risk for keratinocyte carcinoma in the veterans affairs topical tretinoin chemoprevention trial. Ann Intern Med. 2009 Jan 6; 150(1):9-18.
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        60. Gruneir A, Lapane KL, Miller SC, Mor V. Does the presence of a dementia special care unit improve nursing home quality? J Aging Health. 2008 Oct; 20(7):837-54.
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        61. Jalbert JJ, Quilliam BJ, Lapane KL. A profile of concurrent alcohol and alcohol-interactive prescription drug use in the US population. J Gen Intern Med. 2008 Sep; 23(9):1318-23.
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        62. Jalbert JJ, Lapane KL. Unhealthy alcohol consumption among older adults. J Am Geriatr Soc. 2008 Sep; 56(9):1769-70.
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        63. Christian JB, Lapane KL, Hume AL, Eaton CB, Weinstock MA. Association of ACE inhibitors and angiotensin receptor blockers with keratinocyte cancer prevention in the randomized VATTC trial. J Natl Cancer Inst. 2008 Sep 3; 100(17):1223-32.
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        64. Jalbert JJ, Daiello LA, Lapane KL. Dementia of the Alzheimer type. Epidemiol Rev. 2008; 30:15-34.
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        65. Waring ME, Lapane KL. Overweight in children and adolescents in relation to attention-deficit/hyperactivity disorder: results from a national sample. Pediatrics. 2008 Jul; 122(1):e1-6.
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        66. Peipert JF, Lapane KL, Allsworth JE, Redding CA, Blume JD, Stein MD. Bacterial vaginosis, race, and sexually transmitted infections: does race modify the association? Sex Transm Dis. 2008 Apr; 35(4):363-7.
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        67. Garber CE, Allsworth JE, Marcus BH, Hesser J, Lapane KL. Correlates of the stages of change for physical activity in a population survey. Am J Public Health. 2008 May; 98(5):897-904.
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        68. Lapane KL, Waring ME, Schneider KL, Dubé C, Quilliam BJ. A mixed method study of the merits of e-prescribing drug alerts in primary care. J Gen Intern Med. 2008 Apr; 23(4):442-6.
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        69. Gruneir A, Lapane KL. It is time to assess the role of organizational culture in nursing home prescribing patterns. Arch Intern Med. 2008 Jan 28; 168(2):238-9; author reply 239.
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        70. Smith LM, Lapane KL, Fennell ML, Miller EA, Mor V. Home health agency profit orientation and risk for hospitalization: a propensity score analysis of population weighted data. Home Health Care Serv Q. 2008; 27(3):240-57.
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        71. Gruneir A, Lapane KL, Miller SC, Mor V. Is dementia special care really special? A new look at an old question. J Am Geriatr Soc. 2008 Feb; 56(2):199-205.
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        72. Lapane KL, Dubé CE, Schneider KL, Quilliam BJ. Misperceptions of patients vs providers regarding medication-related communication issues. Am J Manag Care. 2007 Nov; 13(11):613-8.
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        73. Peipert JF, Lapane KL, Allsworth JE, Redding CA, Blume JL, Lozowski F, Stein MD. Women at risk for sexually transmitted diseases: correlates of intercourse without barrier contraception. Am J Obstet Gynecol. 2007 Nov; 197(5):474.e1-8.
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        74. Lapane KL, Quilliam BJ, Hughes CM. A comparison of two distribution methods on response rates to a patient safety questionnaire in nursing homes. J Am Med Dir Assoc. 2007 Sep; 8(7):446-52.
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        75. Gruneir A, Lapane KL, Miller SC, Mor V. Long-term care market competition and nursing home dementia special care units. Med Care. 2007 Aug; 45(8):739-45.
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        76. Lapane KL, Dubé C, Schneider KL, Quilliam BJ. Patient perceptions regarding electronic prescriptions: is the geriatric patient ready? J Am Geriatr Soc. 2007 Aug; 55(8):1254-9.
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        77. Lapane K, Weinstock MA. The power and limitations of pharmacogenetic epidemiology. J Invest Dermatol. 2007 Aug; 127(8):1851-2.
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        78. Spinewine A, Schmader KE, Barber N, Hughes C, Lapane KL, Swine C, Hanlon JT. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007 Jul 14; 370(9582):173-84.
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        79. Lapane KL, Quilliam BJ, Dore DD. Roadblock on the health IT superhighway: e-prescribing and the Controlled Substances Act. J Opioid Manag. 2007 Jul-Aug; 3(4):181-4.
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        80. Schneider KL, Lapane KL. Adult health behaviors. Public Health Rep. 2007 Jul-Aug; 122(4):432; author reply 432-3.
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        81. Patterson SM, Hughes CM, Lapane KL. Assessment of a United States pharmaceutical care model for nursing homes in the United Kingdom. Pharm World Sci. 2007 Oct; 29(5):517-25.
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        82. Liperoti R, Onder G, Lapane KL, Mor V, Friedman JH, Bernabei R, Gambassi G. Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. J Clin Psychiatry. 2007 Jun; 68(6):929-34.
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        83. Lapane KL, Hughes CM, Quilliam BJ. Does incorporating medications in the surveyors' interpretive guidelines reduce the use of potentially inappropriate medications in nursing homes? J Am Geriatr Soc. 2007 May; 55(5):666-73.
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        84. Hughes CM, Lapane K, Watson MC, Davies HT. Does organisational culture influence prescribing in care homes for older people? A new direction for research. Drugs Aging. 2007; 24(2):81-93.
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        85. Dore DD, DiBello JR, Lapane KL. Telithromycin use and spontaneous reports of hepatotoxicity. Drug Saf. 2007; 30(8):697-703.
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        86. Lapane KL, Hiris J, Hughes CM, Feinberg J. Development and implementation of pharmaceutical care planning software for nursing homes based on the Fleetwood Model. Am J Health Syst Pharm. 2006 Dec 15; 63(24):2483-7.
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        87. Lapane KL, Hughes CM. Adherence to the components of the Fleetwood model: self-reported process measures in the Fleetwood Phase III study. Consult Pharm. 2006 Dec; 21(12):981-7.
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        88. Oliveria SA, Liperoti R, L'italien G, Pugner K, Safferman A, Carson W, Lapane K. Adverse events among nursing home residents with Alzheimer's disease and psychosis. Pharmacoepidemiol Drug Saf. 2006 Nov; 15(11):763-74.
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        89. Gruneir A, Miller SC, Lapane KL, Kinzbrunner B. Hospice care in the nursing home: changes in visit volume from enrollment to discharge among longer-stay residents. J Pain Symptom Manage. 2006 Nov; 32(5):478-87.
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        90. Lapane KL, Hughes CM. Pharmacotherapy interventions undertaken by pharmacists in the Fleetwood phase III study: the role of process control. Ann Pharmacother. 2006 Sep; 40(9):1522-6.
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        91. Lapane KL, Hughes CM. Considering the employee point of view: perceptions of job satisfaction and stress among nursing staff in nursing homes. J Am Med Dir Assoc. 2007 Jan; 8(1):8-13.
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        92. Hughes CM, Lapane KL. Nurses' and nursing assistants' perceptions of patient safety culture in nursing homes. Int J Qual Health Care. 2006 Aug; 18(4):281-6.
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        93. Boardman LA, Allsworth J, Phipps MG, Lapane KL. Risk factors for unintended versus intended rapid repeat pregnancies among adolescents. J Adolesc Health. 2006 Oct; 39(4):597.e1-8.
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        94. Lapane KL, Hughes CM. Job satisfaction and stress among pharmacists in the long-term care sector. Consult Pharm. 2006 Apr; 21(4):287-92.
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        95. Hughes CM, Wright RM, Lapane KL. Use of medication technicians in US nursing homes: part of the problem or part of the solution? J Am Med Dir Assoc. 2006 Jun; 7(5):294-304.
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        96. Won A, Lapane KL, Vallow S, Schein J, Morris JN, Lipsitz LA. Long-term effects of analgesics in a population of elderly nursing home residents with persistent nonmalignant pain. J Gerontol A Biol Sci Med Sci. 2006 Feb; 61(2):165-9.
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        97. Lapane KL, Resnik L. Weighing the relevant issues: obesity in nursing homes. J Aging Soc Policy. 2006; 18(2):1-9.
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        98. Lapane KL, Hughes CM. Did the introduction of a prospective payment system for nursing home stays reduce the likelihood of pharmacological management of secondary ischaemic stroke? Drugs Aging. 2006; 23(1):61-9.
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        99. Liperoti R, Pedone C, Lapane KL, Mor V, Bernabei R, Gambassi G. Venous thromboembolism among elderly patients treated with atypical and conventional antipsychotic agents. Arch Intern Med. 2005 Dec 12-26; 165(22):2677-82.
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        100. Wu N, Miller SC, Lapane K, Roy J, Mor V. Impact of cognitive function on assessments of nursing home residents' pain. Med Care. 2005 Sep; 43(9):934-9.
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        101. Liperoti R, Gambassi G, Lapane KL, Chiang C, Pedone C, Mor V, Bernabei R. Cerebrovascular events among elderly nursing home patients treated with conventional or atypical antipsychotics. J Clin Psychiatry. 2005 Sep; 66(9):1090-6.
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        102. Lapane KL, Resnik L. Obesity in nursing homes: an escalating problem. J Am Geriatr Soc. 2005 Aug; 53(8):1386-91.
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        103. Resnik L, Lapane KL, Allen SM. Obesity and receipt of personal care assistance for people with mobility impairments. Obes Res. 2005 Aug; 13(8):1307-10.
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        104. Wu N, Miller SC, Lapane K, Roy J, Mor V. The quality of the quality indicator of pain derived from the minimum data set. Health Serv Res. 2005 Aug; 40(4):1197-216.
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        105. Lapane KL, Jesdale W, Zierler S. Racial differences in pressure ulcer prevalence in nursing homes. J Am Geriatr Soc. 2005 Jun; 53(6):1077-8.
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        106. Weitzen S, Lapane KL, Toledano AY, Hume AL, Mor V. Weaknesses of goodness-of-fit tests for evaluating propensity score models: the case of the omitted confounder. Pharmacoepidemiol Drug Saf. 2005 Apr; 14(4):227-38.
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        107. Liperoti R, Gambassi G, Lapane KL, Chiang C, Pedone C, Mor V, Bernabei R. Conventional and atypical antipsychotics and the risk of hospitalization for ventricular arrhythmias or cardiac arrest. Arch Intern Med. 2005 Mar 28; 165(6):696-701.
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        108. Gasper MC, Ott BR, Lapane KL. Is donepezil therapy associated with reduced mortality in nursing home residents with dementia? Am J Geriatr Pharmacother. 2005 Mar; 3(1):1-7.
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        109. Allsworth JE, Toppa R, Palin NC, Lapane KL. For the patient. Many nursing home patients do not receive diabetes medicine. Ethn Dis. 2005; 15(2):351.
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        110. Allsworth JE, Toppa R, Palin NC, Lapane KL. Racial and ethnic disparities in the pharmacologic management of diabetes mellitus among long-term care facility residents. Ethn Dis. 2005; 15(2):205-12.
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        111. Hughes CM, Lapane KL. Administrative initiatives for reducing inappropriate prescribing of psychotropic drugs in nursing homes: how successful have they been? Drugs Aging. 2005; 22(4):339-51.
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        112. Weitzen S, Lapane KL, Toledano AY, Hume AL, Mor V. Principles for modeling propensity scores in medical research: a systematic literature review. Pharmacoepidemiol Drug Saf. 2004 Dec; 13(12):841-53.
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        113. Allsworth JE, Zierler S, Lapane KL, Krieger N, Hogan JW, Harlow BL. Longitudinal study of the inception of perimenopause in relation to lifetime history of sexual or physical violence. J Epidemiol Community Health. 2004 Nov; 58(11):938-43.
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        114. Lapane KL, Hughes CM. Baseline job satisfaction and stress among pharmacists and pharmacy technicians participating in the Fleetwood Phase III Study. Consult Pharm. 2004 Nov; 19(11):1029-37.
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        115. Christian JB, Vanhaaren A, Cameron KA, Lapane KL. Alternatives for potentially inappropriate medications in the elderly population: treatment algorithms for use in the Fleetwood Phase III Study. Consult Pharm. 2004 Nov; 19(11):1011-28.
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        116. Lapane KL, Hughes CM. Which organizational characteristics are associated with increased management of depression using antidepressants in US nursing homes? Med Care. 2004 Oct; 42(10):992-1000.
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        117. Ott BR, Lapane KL. Mortality in donepezil-treated patients. J Am Geriatr Soc. 2004 Aug; 52(8):1412-3; author reply 1413.
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        118. Hughes CM, Lapane KL. Factors associated with the initiation and discontinuation of secondary stroke prevention agents in nursing homes. J Stroke Cerebrovasc Dis. 2004 Jul-Aug; 13(4):164-70.
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        119. Bradley EH, Webster TR, Baker D, Schlesinger M, Inouye SK, Barth MC, Lapane KL, Lipson D, Stone R, Koren MJ. Translating research into practice: speeding the adoption of innovative health care programs. Issue Brief (Commonw Fund). 2004 Jul; (724):1-12.
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        120. Won AB, Lapane KL, Vallow S, Schein J, Morris JN, Lipsitz LA. Persistent nonmalignant pain and analgesic prescribing patterns in elderly nursing home residents. J Am Geriatr Soc. 2004 Jun; 52(6):867-74.
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        121. Lapane KL, Hughes CM. Identifying nursing home residents at high risk for preventable adverse drug events: modifying a tool for use in the Fleetwood Phase III Study. Consult Pharm. 2004 Jun; 19(6):533-7.
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        122. Davis JA, Lapane KL. Do characteristics associated with nursing home residents vary by race/ethnicity? J Health Care Poor Underserved. 2004 May; 15(2):251-66.
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        123. Boardman LA, Weitzen S, Lapane KL. Context of care and contraceptive method use. Womens Health Issues. 2004 Mar-Apr; 14(2):51-9.
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        124. Pedone C, Lapane KL, Mor V, Bernabei R. Donepezil use in US nursing homes. Aging Clin Exp Res. 2004 Feb; 16(1):60-7.
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        125. Peipert JF, Weitzen S, Cruickshank C, Story E, Ethridge D, Lapane K. Risk factors for febrile morbidity after hysterectomy. Obstet Gynecol. 2004 Jan; 103(1):86-91.
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        126. Lapane KL, Hughes CM. An evaluation of the impact of the prospective payment system on antidepressant use in nursing home residents. Med Care. 2004 Jan; 42(1):48-58.
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        127. Wu N, Miller SC, Lapane K, Gozalo P. The problem of assessment bias when measuring the hospice effect on nursing home residents' pain. J Pain Symptom Manage. 2003 Nov; 26(5):998-1009.
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        128. Christian JB, Lapane KL, Toppa RS. Racial disparities in receipt of secondary stroke prevention agents among US nursing home residents. Stroke. 2003 Nov; 34(11):2693-7.
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        129. Liperoti R, Mor V, Lapane KL, Pedone C, Gambassi G, Bernabei R. The use of atypical antipsychotics in nursing homes. J Clin Psychiatry. 2003 Sep; 64(9):1106-12.
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        130. Pedone C, Lapane KL. Generalizability of guidelines and physicians' adherence. Case study on the Sixth Joint National Commitee's guidelines on hypertension. BMC Public Health. 2003 Jul 21; 3:24.
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        131. Assaf AR, Parker D, Lapane KL, Coccio E, Evangelou E, Carleton RA. Does the Y chromosome make a difference? Gender differences in attempts to change cardiovascular disease risk factors. J Womens Health (Larchmt). 2003 May; 12(4):321-30.
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        132. Assaf AR, Parker D, Lapane KL, McKenney JL, Carleton RA. Are there gender differences in self-reported smoking practices? Correlation with thiocyanate and cotinine levels in smokers and nonsmokers from the Pawtucket Heart Health Program. J Womens Health (Larchmt). 2002 Dec; 11(10):899-906.
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        133. Rojas-Fernandez CH, Lapane KL, MacKnight C, Howard KA. Undertreatment of osteoporosis in residents of nursing homes: population-based study with use of the Systematic Assessment of Geriatric Drug Use via Epidemiology (SAGE) database. Endocr Pract. 2002 Sep-Oct; 8(5):335-42.
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        134. Ott BR, Belazi D, Lapane KL. Cognitive decline among female estrogen users in nursing homes. J Gerontol A Biol Sci Med Sci. 2002 Sep; 57(9):M594-8.
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        135. Eaton CB, Lapane KL, Murphy JB, Hume AL. Effect of statin (HMG-Co-A-Reductase Inhibitor) use on 1-year mortality and hospitalization rates in older patients with cardiovascular disease living in nursing homes. J Am Geriatr Soc. 2002 Aug; 50(8):1389-95.
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        136. Lapane KL, Hume AL, Barbour MM, Lipsitz LA. Does aspirin attenuate the effect of angiotensin-converting enzyme inhibitors on health outcomes of very old patients with heart failure? J Am Geriatr Soc. 2002 Jul; 50(7):1198-204.
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        137. Fernandez HH, Lapane KL. Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease. Med Sci Monit. 2002 Apr; 8(4):CR241-6.
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        138. Miller SC, Mor V, Wu N, Gozalo P, Lapane K. Does receipt of hospice care in nursing homes improve the management of pain at the end of life? J Am Geriatr Soc. 2002 Mar; 50(3):507-15.
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        139. Brown MN, Lapane KL, Luisi AF. The management of depression in older nursing home residents. J Am Geriatr Soc. 2002 Jan; 50(1):69-76.
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        140. Lapane KL, Hughes CM. Optimising drug utilisation in long term care. Pharmacoeconomics. 2002; 20(3):143-52.
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        141. Dhall J, Larrat EP, Lapane KL. Use of potentially inappropriate drugs in nursing homes. Pharmacotherapy. 2002 Jan; 22(1):88-96.
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        142. Hughes CM, Lapane KL. The drive for quality care in US nursing homes in the era of the prospective payment system. Drugs Aging. 2002; 19(9):623-31.
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        143. Ott BR, Lapane KL. Tacrine therapy is associated with reduced mortality in nursing home residents with dementia. J Am Geriatr Soc. 2002 Jan; 50(1):35-40.
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        144. VanHaaren AM, Lapane KL, Hughes CM. Effect of triplicate prescription policy on benzodiazepine administration in nursing home residents. Pharmacotherapy. 2001 Oct; 21(10):1159-66.
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        145. Quilliam BJ, Lapane KL, Eaton CB, Mor V. Effect of antiplatelet and anticoagulant agents on risk of hospitalization for bleeding among a population of elderly nursing home stroke survivors. Stroke. 2001 Oct; 32(10):2299-304.
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        146. Derby CA, Lapane KL, Feldman HA, Carleton RA. Possible effect of DRGs on the classification of stroke: implications for epidemiological surveillance. Stroke. 2001 Jul; 32(7):1487-91.
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        147. Quilliam BJ, Lapane KL. Clinical correlates and drug treatment of residents with stroke in long-term care. Stroke. 2001 Jun; 32(6):1385-93.
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        148. Lapane KL, Spooner JJ, Mucha L, Straus WL. Effect of nonsteroidal anti-inflammatory drug use on the rate of gastrointestinal hospitalizations among people living in long-term care. J Am Geriatr Soc. 2001 May; 49(5):577-84.
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        149. Spooner JJ, Lapane KL, Hume AL, Mor V, Gambassi G. Pharmacologic treatment of diabetes in long-term care. J Clin Epidemiol. 2001 May; 54(5):525-30.
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        150. Lapane KL, Spooner JJ, Pettitt D. The effect of nonsteroidal anti-inflammatory drugs on the use of gastroprotective medication in people with arthritis. Am J Manag Care. 2001 Apr; 7(4):402-8.
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        151. Lapane KL, Gambassi G, Landi F, Sgadari A, Mor V, Bernabei R. Gender differences in predictors of mortality in nursing home residents with AD. Neurology. 2001 Mar 13; 56(5):650-4.
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        152. Hughes CM, Lapane KL, Mor V. Influence of facility characteristics on use of antipsychotic medications in nursing homes. Med Care. 2000 Dec; 38(12):1164-73.
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        153. Fernandez HH, Lapane KL. Estrogen use among nursing home residents with a diagnosis of Parkinson's disease. Mov Disord. 2000 Nov; 15(6):1119-24.
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        154. Hughes CM, Lapane KL, Mor V, Ikegami N, Jónsson PV, Ljunggren G, Sgadari A. The impact of legislation on psychotropic drug use in nursing homes: a cross-national perspective. J Am Geriatr Soc. 2000 Aug; 48(8):931-7.
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        155. Fernandez HH, Lapane KL, Ott BR, Friedman JH. Gender differences in the frequency and treatment of behavior problems in Parkinson's disease. SAGE Study Group. Systematic Assessment and Geriatric drug use via Epidemiology. Mov Disord. 2000 May; 15(3):490-6.
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        156. Sgadari A, Lapane KL, Mor V, Landi F, Bernabei R, Gambassi G. Oxidative and nonoxidative benzodiazepines and the risk of femur fracture. The Systematic Assessment of Geriatric Drug Use Via Epidemiology Study Group. J Clin Psychopharmacol. 2000 Apr; 20(2):234-9.
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        157. Derby CA, Lapane KL, Feldman HA, Carleton RA. Trends in validated cases of fatal and nonfatal stroke, stroke classification, and risk factors in southeastern New England, 1980 to 1991 : data from the Pawtucket Heart Health Program. Stroke. 2000 Apr; 31(4):875-81.
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        158. Assaf AR, Lapane KL, McKenney JL, McKinlay S, Carleton RA. Coronary heart disease surveillance: field application of an epidemiologic algorithm. J Clin Epidemiol. 2000 Apr; 53(4):419-26.
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        159. Derby CA, Lapane KL, Feldman HA, Carleton RA. Sex-specific trends in validated coronary heart disease rates in southeastern New England, 1980-1991. Am J Epidemiol. 2000 Feb 15; 151(4):417-29.
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        160. Ott BR, Lapane KL, Gambassi G. Gender differences in the treatment of behavior problems in Alzheimer's disease. SAGE Study Group. Systemic Assessment of Geriatric drug use via Epidemiology. Neurology. 2000 Jan 25; 54(2):427-32.
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        161. Gambassi G, Lapane KL, Sgadari A, Carbonin P, Gatsonis C, Lipsitz LA, Mor V, Bernabei R. Effects of angiotensin-converting enzyme inhibitors and digoxin on health outcomes of very old patients with heart failure. SAGE Study Group. Systematic Assessment of Geriatric drug use via Epidemiology. Arch Intern Med. 2000 Jan 10; 160(1):53-60.
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        162. Gambassi G, Forman DE, Lapane KL, Mor V, Sgadari A, Lipsitz LA, Bernabei R. Management of heart failure among very old persons living in long-term care: has the voice of trials spread? The SAGE Study Group. Am Heart J. 2000 Jan; 139(1 Pt 1):85-93.
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        163. Lapane KL, Fernandez HH, Friedman JH. Prevalence, clinical characteristics, and pharmacologic treatment of Parkinson's disease in residents in long-term care facilities. SAGE Study Group. Pharmacotherapy. 1999 Nov; 19(11):1321-7.
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        164. Eaton CB, Lapane KL, Garber CE, Gans KM, Lasater TM, Carleton RA. Effects of a community-based intervention on physical activity: the Pawtucket Heart Health Program. Am J Public Health. 1999 Nov; 89(11):1741-4.
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        165. Hughes CM, Lapane KL, Mor V. Impact of legislation on nursing home care in the United States: lessons for the United Kingdom. BMJ. 1999 Oct 16; 319(7216):1060-2.
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        166. Gambassi G, Lapane KL, Landi F, Sgadari A, Mor V, Bernabie R. Gender differences in the relation between comorbidity and mortality of patients with Alzheimer's disease. Systematic Assessment of Geriatric drug use via Epidemiology (SAGE) Study Group. Neurology. 1999 Aug 11; 53(3):508-16.
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        167. Won A, Lapane K, Gambassi G, Bernabei R, Mor V, Lipsitz LA. Correlates and management of nonmalignant pain in the nursing home. SAGE Study Group. Systematic Assessment of Geriatric drug use via Epidemiology. J Am Geriatr Soc. 1999 Aug; 47(8):936-42.
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        168. Beaulieu AJ, Lapane KL, Gohh RY, Selhub J, Monaco AP, Dworkin L, Rosenberg IH, Bostom AG. Short-term reproducibility of total homocysteine determinations in stable renal transplant recipients. Transplant Proc. 1999 Aug; 31(5):2121-3.
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        169. Gambassi G, Landi F, Lapane KL, Sgadari A, Mor V, Bernabei R. Predictors of mortality in patients with Alzheimer's disease living in nursing homes. J Neurol Neurosurg Psychiatry. 1999 Jul; 67(1):59-65.
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        170. Lapane KL, Barbour MM, Van Haaren A, Gambassi G. Antiischemic therapy in patients with coronary heart disease living in long-term care. Systematic Assessment of Geriatric Drug Use by Epidemiology (SAGE) Group. Pharmacotherapy. 1999 May; 19(5):627-34.
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        171. Shemin D, Lapane KL, Bausserman L, Kanaan E, Kahn S, Dworkin L, Bostom AG. Plasma total homocysteine and hemodialysis access thrombosis: a prospective study. J Am Soc Nephrol. 1999 May; 10(5):1095-9.
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        172. Gambassi G, Landi F, Lapane KL, Sgadari A, Mor V, Bernabei R. Is drug use by the elderly with cognitive impairment influenced by type of dementia? Pharmacotherapy. 1999 Apr; 19(4):430-6.
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        173. Wang JS, Carson EC, Lapane KL, Eaton CB, Gans KM, Lasater TM. The effect of physician office visits on CHD risk factor modification as part of a worksite cholesterol screening program. Prev Med. 1999 Mar; 28(3):221-8.
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        174. Landi F, Gambassi G, Lapane KL, Sgadari A, Mor V, Bernabei R. Impact of the type and severity of dementia on hospitalization and survival of the elderly. The SAGE Study Group. Dement Geriatr Cogn Disord. 1999 Mar-Apr; 10(2):121-9.
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        175. Gifford DR, Lapane KL, Gambassi G, Landi F, Mor V, Bernabei R. Tacrine use in nursing homes: implications for prescribing new cholinesterase inhibitors. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. Neurology. 1999 Jan 15; 52(2):238-44.
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        176. Bernabei R, Gambassi G, Lapane K, Sgadari A, Landi F, Gatsonis C, Lipsitz L, Mor V. Characteristics of the SAGE database: a new resource for research on outcomes in long-term care. SAGE (Systematic Assessment of Geriatric drug use via Epidemiology) Study Group. J Gerontol A Biol Sci Med Sci. 1999 Jan; 54(1):M25-33.
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        177. Forman DE, Chander RB, Lapane KL, Shah P, Stoukides J. Evaluating the use of angiotensin-converting enzyme inhibitors for older nursing home residents with chronic heart failure. J Am Geriatr Soc. 1998 Dec; 46(12):1550-4.
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        178. Parker DR, Lapane KL, Lasater TM, Carleton RA. Short stature and cardiovascular disease among men and women from two southeastern New England communities. Int J Epidemiol. 1998 Dec; 27(6):970-5.
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        179. Gambassi G, Lapane K, Sgadari A, Landi F, Carbonin P, Hume A, Lipsitz L, Mor V, Bernabei R. Prevalence, clinical correlates, and treatment of hypertension in elderly nursing home residents. SAGE (Systematic Assessment of Geriatric Drug Use via Epidemiology) Study Group. Arch Intern Med. 1998 Nov 23; 158(21):2377-85.
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        180. Landi F, Gambassi G, Lapane KL, Sgadari A, Gifford D, Mor V, Bernabei R. Comorbidity and drug use in cognitively impaired elderly living in long-term care. Dement Geriatr Cogn Disord. 1998 Nov-Dec; 9(6):347-56.
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        181. Gambassi G, Lapane KL, Sgadari A, Bernabei R. Elderly patients, use of antidepressants, and hip fracture. Lancet. 1998 Aug 1; 352(9125):400; author reply 401-2.
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        182. Bernabei R, Gambassi G, Lapane K, Landi F, Gatsonis C, Dunlop R, Lipsitz L, Steel K, Mor V. Management of pain in elderly patients with cancer. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. JAMA. 1998 Jun 17; 279(23):1877-82.
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        183. Lapane KL, Jakiche AF, Sugano D, Weng CS, Carey WD. Hepatitis C infection risk analysis: who should be screened? Comparison of multiple screening strategies based on the National Hepatitis Surveillance Program. Am J Gastroenterol. 1998 Apr; 93(4):591-6.
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        184. Lapane KL, Hume AL. Adverse outcomes of underuse of beta-blockers in elderly patients. JAMA. 1997 May 14; 277(18):1435; author reply 1436-7.
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        185. Derby CA, Lapane KL, Hume AL, Babour MM, Carleton RA. Is cigarette smoking an effect modifier of the relation between antihypertensive therapy and blood lipids? Epidemiology. 1997 Jan; 8(1):48-54.
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        186. Hume AL, Barbour MM, Lapane KL, Flint PM, Carleton RA. Correlates of oral contraceptive use in two New England communities: 1981-1993. Pharmacotherapy. 1996 Nov-Dec; 16(6):1173-8.
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        187. Bostom AG, Shemin D, Lapane KL, Sutherland P, Nadeau MR, Wilson PW, Yoburn D, Bausserman L, Tofler G, Jacques PF, Selhub J, Rosenberg IH. Hyperhomocysteinemia, hyperfibrinogenemia, and lipoprotein (a) excess in maintenance dialysis patients: a matched case-control study. Atherosclerosis. 1996 Aug 23; 125(1):91-101.
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        188. Parker DR, Derby CA, Usner DW, Gonzalez S, Lapane KL, Carleton RA. Self-reported alcohol intake using two different question formats in southeastern New England. Int J Epidemiol. 1996 Aug; 25(4):770-4.
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        189. Bostom AG, Shemin D, Lapane KL, Nadeau MR, Sutherland P, Chan J, Rozen R, Yoburn D, Jacques PF, Selhub J, Rosenberg IH. Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients. Atherosclerosis. 1996 Jun; 123(1-2):193-202.
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        190. Bostom AG, Shemin D, Lapane KL, Hume AL, Yoburn D, Nadeau MR, Bendich A, Selhub J, Rosenberg IH. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int. 1996 Jan; 49(1):147-52.
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        191. Eaton CB, Lapane KL, Garber CA, Assaf AR, Lasater TM, Carleton RA. Sedentary lifestyle and risk of coronary heart disease in women. Med Sci Sports Exerc. 1995 Nov; 27(11):1535-9.
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        192. McKenney JL, Lapane KL, Assaf AR, Carleton RA. The association between perceived risk and actual cardiovascular disease. Epidemiology. 1995 Nov; 6(6):612-6.
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        193. Flint PM, Lapane KL, Barbour MM, Derby CA, Carleton RA, Hume AL. Cardiovascular risk profiles of oral contraceptive users and nonusers: a population-based study. Prev Med. 1995 Nov; 24(6):586-90.
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        194. Lapane KL, Zierler S, Lasater TM, Stein M, Barbour MM, Hume AL. Is a history of depressive symptoms associated with an increased risk of infertility in women? Psychosom Med. 1995 Nov-Dec; 57(6):509-13; discussion 514-6.
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        195. Lapane KL, Zierler S, Lasater TM, Barbour MM, Carleton R, Hume AL. Is the use of psychotropic drugs associated with increased risk of ischemic heart disease? Epidemiology. 1995 Jul; 6(4):376-81.
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        196. Barbour MM, Hume AL, Lapane KL, Derby CA, Carleton RA. Predictors of future antihypertensive use in patients with mildly elevated blood pressure. Pharmacotherapy. 1995 May-Jun; 15(3):272-8.
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        197. Bostom AG, Shemin D, Lapane KL, Miller JW, Sutherland P, Nadeau M, Seyoum E, Hartman W, Prior R, Wilson PW, et al. Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: a case-control study. Atherosclerosis. 1995 Apr 7; 114(1):93-103.
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        198. Gans KM, Lapane K. Trans fatty acid and coronary disease: the debate continues. 3. What should we tell consumers? Am J Public Health. 1995 Mar; 85(3):411-2.
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        199. Eaton CB, Lapane KL, Garber CE, Assaf AR, Lasater TM, Carleton RA. Physical activity, physical fitness, and coronary heart disease risk factors. Med Sci Sports Exerc. 1995 Mar; 27(3):340-6.
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        200. Parker DR, McPhillips JB, Lapane KL, Lasater TM, Carleton RA. Nutrition and health practices of diabetic and nondiabetic men and women from two southeastern New England communities. Nutr Health. 1995; 10(3):255-68.
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        201. Hume AL, Barbour MM, Lapane KL, Carleton RA. Is antidepressant use changing? Prevalence and clinical correlates in two New England communities. Pharmacotherapy. 1995 Jan-Feb; 15(1):78-84.
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        202. Gans KM, Lapane KL, Lasater TM, Carleton RA. Effects of intervention on compliance to referral and lifestyle recommendations given at cholesterol screening programs. Am J Prev Med. 1994 Sep-Oct; 10(5):275-82.
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        203. Assaf AR, Lapane KL, McKenney JL, Carleton RA. Possible influence of the prospective payment system on the assignment of discharge diagnoses for coronary heart disease. N Engl J Med. 1993 Sep 23; 329(13):931-5.
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        204. Hume AL, Barbour MM, Willey CJ, Assaf AR, Lapane KL, Carleton RA. Changing trends in antihypertensive therapy in two New England communities during the 1980s. Pharmacotherapy. 1993 May-Jun; 13(3):244-51.
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        205. Hume AL, Barbour MM, Lapane KL, Assaf AR, Carleton RA. Prevalence and descriptors of aspirin use as an antiplatelet agent in two New England communities. Ann Pharmacother. 1993 Apr; 27(4):442-4.
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